Summary | |
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Symbol | LAMA5 |
Name | laminin, alpha 5 |
Aliases | laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ...... |
Chromosomal Location | 20q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. |
Domain |
PF00052 Laminin B (Domain IV) PF00053 Laminin EGF domain PF02210 Laminin G domain PF06008 Laminin Domain I PF06009 Laminin Domain II PF00055 Laminin N-terminal (Domain VI) |
Function |
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
Biological Process |
GO:0001525 angiogenesis GO:0001655 urogenital system development GO:0001657 ureteric bud development GO:0001658 branching involved in ureteric bud morphogenesis GO:0001667 ameboidal-type cell migration GO:0001738 morphogenesis of a polarized epithelium GO:0001755 neural crest cell migration GO:0001763 morphogenesis of a branching structure GO:0001822 kidney development GO:0001823 mesonephros development GO:0001942 hair follicle development GO:0003158 endothelium development GO:0007009 plasma membrane organization GO:0007044 cell-substrate junction assembly GO:0007045 cell-substrate adherens junction assembly GO:0007160 cell-matrix adhesion GO:0007229 integrin-mediated signaling pathway GO:0007431 salivary gland development GO:0007435 salivary gland morphogenesis GO:0007517 muscle organ development GO:0008037 cell recognition GO:0008544 epidermis development GO:0010927 cellular component assembly involved in morphogenesis GO:0014031 mesenchymal cell development GO:0014032 neural crest cell development GO:0014033 neural crest cell differentiation GO:0016331 morphogenesis of embryonic epithelium GO:0022404 molting cycle process GO:0022405 hair cycle process GO:0022612 gland morphogenesis GO:0030031 cell projection assembly GO:0030198 extracellular matrix organization GO:0030323 respiratory tube development GO:0030324 lung development GO:0031589 cell-substrate adhesion GO:0034329 cell junction assembly GO:0034330 cell junction organization GO:0034332 adherens junction organization GO:0034333 adherens junction assembly GO:0034446 substrate adhesion-dependent cell spreading GO:0035239 tube morphogenesis GO:0035272 exocrine system development GO:0042303 molting cycle GO:0042384 cilium assembly GO:0042475 odontogenesis of dentin-containing tooth GO:0042476 odontogenesis GO:0042633 hair cycle GO:0043062 extracellular structure organization GO:0043588 skin development GO:0044782 cilium organization GO:0045216 cell-cell junction organization GO:0045446 endothelial cell differentiation GO:0045995 regulation of embryonic development GO:0048041 focal adhesion assembly GO:0048514 blood vessel morphogenesis GO:0048732 gland development GO:0048754 branching morphogenesis of an epithelial tube GO:0048762 mesenchymal cell differentiation GO:0048863 stem cell differentiation GO:0048864 stem cell development GO:0060271 cilium morphogenesis GO:0060445 branching involved in salivary gland morphogenesis GO:0060485 mesenchyme development GO:0060541 respiratory system development GO:0060562 epithelial tube morphogenesis GO:0060675 ureteric bud morphogenesis GO:0060993 kidney morphogenesis GO:0061138 morphogenesis of a branching epithelium GO:0061326 renal tubule development GO:0061333 renal tubule morphogenesis GO:0072001 renal system development GO:0072006 nephron development GO:0072009 nephron epithelium development GO:0072028 nephron morphogenesis GO:0072073 kidney epithelium development GO:0072078 nephron tubule morphogenesis GO:0072080 nephron tubule development GO:0072088 nephron epithelium morphogenesis GO:0072163 mesonephric epithelium development GO:0072164 mesonephric tubule development GO:0072171 mesonephric tubule morphogenesis GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0090002 establishment of protein localization to plasma membrane GO:0090150 establishment of protein localization to membrane GO:0098773 skin epidermis development GO:1990778 protein localization to cell periphery |
Molecular Function |
GO:0005178 integrin binding GO:0050839 cell adhesion molecule binding |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005604 basement membrane GO:0005605 basal lamina GO:0005610 laminin-5 complex GO:0043256 laminin complex GO:0043259 laminin-10 complex GO:0043260 laminin-11 complex GO:0044420 extracellular matrix component |
KEGG |
hsa04151 PI3K-Akt signaling pathway hsa04510 Focal adhesion hsa04512 ECM-receptor interaction hsa01100 Metabolic pathways |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-1474228: Degradation of the extracellular matrix R-HSA-3000178: ECM proteoglycans R-HSA-1474244: Extracellular matrix organization R-HSA-168256: Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-3000157: Laminin interactions R-HSA-8874081: MET activates PTK2 signaling R-HSA-8875878: MET promotes cell motility R-HSA-3000171: Non-integrin membrane-ECM interactions R-HSA-162582: Signal Transduction R-HSA-449147: Signaling by Interleukins R-HSA-6806834: Signaling by MET |
Summary | |
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Symbol | LAMA5 |
Name | laminin, alpha 5 |
Aliases | laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ...... |
Chromosomal Location | 20q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LAMA5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | LAMA5 |
Name | laminin, alpha 5 |
Aliases | laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ...... |
Chromosomal Location | 20q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LAMA5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LAMA5 |
Name | laminin, alpha 5 |
Aliases | laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ...... |
Chromosomal Location | 20q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LAMA5 in various data sets.
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Points in the above scatter plot represent the mutation difference of LAMA5 in various data sets.
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Summary | |
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Symbol | LAMA5 |
Name | laminin, alpha 5 |
Aliases | laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ...... |
Chromosomal Location | 20q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LAMA5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | LAMA5 |
Name | laminin, alpha 5 |
Aliases | laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ...... |
Chromosomal Location | 20q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LAMA5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LAMA5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LAMA5 |
Name | laminin, alpha 5 |
Aliases | laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ...... |
Chromosomal Location | 20q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LAMA5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | LAMA5 |
Name | laminin, alpha 5 |
Aliases | laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ...... |
Chromosomal Location | 20q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LAMA5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | LAMA5 |
Name | laminin, alpha 5 |
Aliases | laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ...... |
Chromosomal Location | 20q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LAMA5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | LAMA5 |
Name | laminin, alpha 5 |
Aliases | laminin alpha-5 chain; laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha; Laminin ...... |
Chromosomal Location | 20q13.2-q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LAMA5 collected from DrugBank database. |
Details on drugs targeting LAMA5.
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