Browse LAMC1

Summary
SymbolLAMC1
Namelaminin, gamma 1 (formerly LAMB2)
Aliases S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane.
Domain PF00052 Laminin B (Domain IV)
PF00053 Laminin EGF domain
PF00055 Laminin N-terminal (Domain VI)
Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

> Gene Ontology
 
Biological Process GO:0007044 cell-substrate junction assembly
GO:0007492 endoderm development
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0031581 hemidesmosome assembly
GO:0031589 cell-substrate adhesion
GO:0034329 cell junction assembly
GO:0034330 cell junction organization
GO:0034446 substrate adhesion-dependent cell spreading
GO:0043062 extracellular structure organization
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
Molecular Function GO:0005201 extracellular matrix structural constituent
Cellular Component GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0005605 basal lamina
GO:0005606 laminin-1 complex
GO:0043256 laminin complex
GO:0043259 laminin-10 complex
GO:0043260 laminin-11 complex
GO:0044420 extracellular matrix component
> KEGG and Reactome Pathway
 
KEGG hsa04151 PI3K-Akt signaling pathway
hsa04510 Focal adhesion
hsa04512 ECM-receptor interaction
Reactome R-HSA-422475: Axon guidance
R-HSA-1474228: Degradation of the extracellular matrix
R-HSA-1266738: Developmental Biology
R-HSA-3000178: ECM proteoglycans
R-HSA-1474244: Extracellular matrix organization
R-HSA-373760: L1CAM interactions
R-HSA-3000157: Laminin interactions
R-HSA-8874081: MET activates PTK2 signaling
R-HSA-8875878: MET promotes cell motility
R-HSA-3000171: Non-integrin membrane-ECM interactions
R-HSA-162582: Signal Transduction
R-HSA-6806834: Signaling by MET
Summary
SymbolLAMC1
Namelaminin, gamma 1 (formerly LAMB2)
Aliases S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between LAMC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolLAMC1
Namelaminin, gamma 1 (formerly LAMB2)
Aliases S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of LAMC1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolLAMC1
Namelaminin, gamma 1 (formerly LAMB2)
Aliases S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of LAMC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.7810.031
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.710.781
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.8340.658
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0420.905
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1740.949
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1270.971
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0050.994
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.5170.825
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.6030.812
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.6710.717
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.6660.528
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1680.0815
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of LAMC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414250250.222
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.76.8-3.11
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.76.8-3.11
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolLAMC1
Namelaminin, gamma 1 (formerly LAMB2)
Aliases S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LAMC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolLAMC1
Namelaminin, gamma 1 (formerly LAMB2)
Aliases S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LAMC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LAMC1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolLAMC1
Namelaminin, gamma 1 (formerly LAMB2)
Aliases S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LAMC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolLAMC1
Namelaminin, gamma 1 (formerly LAMB2)
Aliases S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of LAMC1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolLAMC1
Namelaminin, gamma 1 (formerly LAMB2)
Aliases S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between LAMC1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolLAMC1
Namelaminin, gamma 1 (formerly LAMB2)
Aliases S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ......
Chromosomal Location1q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting LAMC1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting LAMC1.
ID Name Drug Type Targets #Targets
DB06245LanoteplaseBiotechANXA2, CALR, CANX, CLEC3B, F10, FGA, FN1, KLK1, KRT8, LAMA1, LAMA3 ......17