Summary | |
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Symbol | LAMC1 |
Name | laminin, gamma 1 (formerly LAMB2) |
Aliases | S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ...... |
Chromosomal Location | 1q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix, basement membrane. |
Domain |
PF00052 Laminin B (Domain IV) PF00053 Laminin EGF domain PF00055 Laminin N-terminal (Domain VI) |
Function |
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
Biological Process |
GO:0007044 cell-substrate junction assembly GO:0007492 endoderm development GO:0022617 extracellular matrix disassembly GO:0030198 extracellular matrix organization GO:0031581 hemidesmosome assembly GO:0031589 cell-substrate adhesion GO:0034329 cell junction assembly GO:0034330 cell junction organization GO:0034446 substrate adhesion-dependent cell spreading GO:0043062 extracellular structure organization GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation |
Molecular Function |
GO:0005201 extracellular matrix structural constituent |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005604 basement membrane GO:0005605 basal lamina GO:0005606 laminin-1 complex GO:0043256 laminin complex GO:0043259 laminin-10 complex GO:0043260 laminin-11 complex GO:0044420 extracellular matrix component |
KEGG |
hsa04151 PI3K-Akt signaling pathway hsa04510 Focal adhesion hsa04512 ECM-receptor interaction |
Reactome |
R-HSA-422475: Axon guidance R-HSA-1474228: Degradation of the extracellular matrix R-HSA-1266738: Developmental Biology R-HSA-3000178: ECM proteoglycans R-HSA-1474244: Extracellular matrix organization R-HSA-373760: L1CAM interactions R-HSA-3000157: Laminin interactions R-HSA-8874081: MET activates PTK2 signaling R-HSA-8875878: MET promotes cell motility R-HSA-3000171: Non-integrin membrane-ECM interactions R-HSA-162582: Signal Transduction R-HSA-6806834: Signaling by MET |
Summary | |
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Symbol | LAMC1 |
Name | laminin, gamma 1 (formerly LAMB2) |
Aliases | S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ...... |
Chromosomal Location | 1q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LAMC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | LAMC1 |
Name | laminin, gamma 1 (formerly LAMB2) |
Aliases | S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ...... |
Chromosomal Location | 1q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LAMC1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | LAMC1 |
Name | laminin, gamma 1 (formerly LAMB2) |
Aliases | S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ...... |
Chromosomal Location | 1q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LAMC1 in various data sets.
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Points in the above scatter plot represent the mutation difference of LAMC1 in various data sets.
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Summary | |
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Symbol | LAMC1 |
Name | laminin, gamma 1 (formerly LAMB2) |
Aliases | S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ...... |
Chromosomal Location | 1q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LAMC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | LAMC1 |
Name | laminin, gamma 1 (formerly LAMB2) |
Aliases | S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ...... |
Chromosomal Location | 1q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LAMC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LAMC1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LAMC1 |
Name | laminin, gamma 1 (formerly LAMB2) |
Aliases | S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ...... |
Chromosomal Location | 1q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LAMC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | LAMC1 |
Name | laminin, gamma 1 (formerly LAMB2) |
Aliases | S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ...... |
Chromosomal Location | 1q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LAMC1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | LAMC1 |
Name | laminin, gamma 1 (formerly LAMB2) |
Aliases | S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ...... |
Chromosomal Location | 1q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LAMC1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | LAMC1 |
Name | laminin, gamma 1 (formerly LAMB2) |
Aliases | S-LAM gamma; S-laminin subunit gamma; laminin B2 chain; laminin-10 subunit gamma; laminin-11 subunit gamma; ...... |
Chromosomal Location | 1q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LAMC1 collected from DrugBank database. |
Details on drugs targeting LAMC1.
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