Browse LAMP1

Summary
SymbolLAMP1
Namelysosomal-associated membrane protein 1
Aliases CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Single-pass type I membrane protein Endosome membrane; Single-pass type I membrane protein Lysosome membrane Single-pass type I membrane protein Late endosome Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (PubMed:16176980).
Domain PF01299 Lysosome-associated membrane glycoprotein (Lamp)
Function

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.; FUNCTION: Acts as a receptor for Lassa virus protein.

> Gene Ontology
 
Biological Process GO:0001906 cell killing
GO:0001909 leukocyte mediated cytotoxicity
GO:0001910 regulation of leukocyte mediated cytotoxicity
GO:0001912 positive regulation of leukocyte mediated cytotoxicity
GO:0002228 natural killer cell mediated immunity
GO:0002263 cell activation involved in immune response
GO:0002285 lymphocyte activation involved in immune response
GO:0002323 natural killer cell activation involved in immune response
GO:0002366 leukocyte activation involved in immune response
GO:0002443 leukocyte mediated immunity
GO:0002449 lymphocyte mediated immunity
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002697 regulation of immune effector process
GO:0002699 positive regulation of immune effector process
GO:0002703 regulation of leukocyte mediated immunity
GO:0002705 positive regulation of leukocyte mediated immunity
GO:0002706 regulation of lymphocyte mediated immunity
GO:0002708 positive regulation of lymphocyte mediated immunity
GO:0002715 regulation of natural killer cell mediated immunity
GO:0002717 positive regulation of natural killer cell mediated immunity
GO:0006887 exocytosis
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006896 Golgi to vacuole transport
GO:0006914 autophagy
GO:0007018 microtubule-based movement
GO:0007034 vacuolar transport
GO:0007041 lysosomal transport
GO:0008626 granzyme-mediated apoptotic signaling pathway
GO:0010970 transport along microtubule
GO:0016482 cytosolic transport
GO:0017157 regulation of exocytosis
GO:0019058 viral life cycle
GO:0030101 natural killer cell activation
GO:0030260 entry into host cell
GO:0030705 cytoskeleton-dependent intracellular transport
GO:0031341 regulation of cell killing
GO:0031343 positive regulation of cell killing
GO:0031349 positive regulation of defense response
GO:0031647 regulation of protein stability
GO:0032386 regulation of intracellular transport
GO:0032814 regulation of natural killer cell activation
GO:0032816 positive regulation of natural killer cell activation
GO:0032886 regulation of microtubule-based process
GO:0042267 natural killer cell mediated cytotoxicity
GO:0042269 regulation of natural killer cell mediated cytotoxicity
GO:0043299 leukocyte degranulation
GO:0043300 regulation of leukocyte degranulation
GO:0043302 positive regulation of leukocyte degranulation
GO:0043320 natural killer cell degranulation
GO:0043321 regulation of natural killer cell degranulation
GO:0043323 positive regulation of natural killer cell degranulation
GO:0044409 entry into host
GO:0045055 regulated exocytosis
GO:0045088 regulation of innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045921 positive regulation of exocytosis
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0046718 viral entry into host cell
GO:0048102 autophagic cell death
GO:0048193 Golgi vesicle transport
GO:0050821 protein stabilization
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0051047 positive regulation of secretion
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051640 organelle localization
GO:0051656 establishment of organelle localization
GO:0051701 interaction with host
GO:0051806 entry into cell of other organism involved in symbiotic interaction
GO:0051828 entry into other organism involved in symbiotic interaction
GO:0060627 regulation of vesicle-mediated transport
GO:0060632 regulation of microtubule-based movement
GO:0072384 organelle transport along microtubule
GO:0090160 Golgi to lysosome transport
GO:1902513 regulation of organelle transport along microtubule
GO:1903305 regulation of regulated secretory pathway
GO:1903307 positive regulation of regulated secretory pathway
GO:1903532 positive regulation of secretion by cell
Molecular Function GO:0001618 virus receptor activity
Cellular Component GO:0005765 lysosomal membrane
GO:0005767 secondary lysosome
GO:0005770 late endosome
GO:0005771 multivesicular body
GO:0008021 synaptic vesicle
GO:0009897 external side of plasma membrane
GO:0010008 endosome membrane
GO:0030133 transport vesicle
GO:0030139 endocytic vesicle
GO:0030141 secretory granule
GO:0030425 dendrite
GO:0030659 cytoplasmic vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030670 phagocytic vesicle membrane
GO:0032010 phagolysosome
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0042599 lamellar body
GO:0043025 neuronal cell body
GO:0044194 cytolytic granule
GO:0044297 cell body
GO:0044440 endosomal part
GO:0045335 phagocytic vesicle
GO:0048770 pigment granule
GO:0061474 phagolysosome membrane
GO:0070382 exocytic vesicle
GO:0097208 alveolar lamellar body
GO:0098552 side of membrane
GO:0098793 presynapse
GO:0098852 lytic vacuole membrane
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04140 Regulation of autophagy
hsa04142 Lysosome
hsa04145 Phagosome
Reactome R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-6798695: Neutrophil degranulation
Summary
SymbolLAMP1
Namelysosomal-associated membrane protein 1
Aliases CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between LAMP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between LAMP1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
21796616MelanomaPromote immunityThe production of multiple cytokines (IFNgamma, TNFalpha, IL-2) and upregulation of LAMP-1 (CD107a) by tumor (Melan-A/MART-1) specific T-cells was comparable to virus (EBV-BMLF1) specific CD8 T-cells. Furthermore, phosphorylation of STAT1, STAT5 and ERK1/2, and expression of CD3 zeta chain were similar in tumor- and virus-specific T-cells, demonstrating functional signaling pathways.
21792901renal cell carcinoma; melanoma; colon carcinomaPromote immunity (T cell function)The CD8 tumor-infiltrating T lymphocytes in 6-gingerol-treated mice strongly expressed IFN-γ, a marker of activation of cytotoxic T lymphocytes (CTL) CD107a and chemokine receptors that are expressed on T(H) 1 cells, such as CXCR3 and CCR5.
Summary
SymbolLAMP1
Namelysosomal-associated membrane protein 1
Aliases CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of LAMP1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolLAMP1
Namelysosomal-associated membrane protein 1
Aliases CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of LAMP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.4770.0506
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.720.836
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3050.902
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2270.504
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0630.979
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5940.842
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0430.933
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0910.967
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2120.932
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.60.784
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0910.737
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0580.425
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of LAMP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.407.40.0709
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.407.40.096
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolLAMP1
Namelysosomal-associated membrane protein 1
Aliases CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LAMP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolLAMP1
Namelysosomal-associated membrane protein 1
Aliases CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LAMP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LAMP1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolLAMP1
Namelysosomal-associated membrane protein 1
Aliases CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LAMP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolLAMP1
Namelysosomal-associated membrane protein 1
Aliases CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of LAMP1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolLAMP1
Namelysosomal-associated membrane protein 1
Aliases CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between LAMP1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolLAMP1
Namelysosomal-associated membrane protein 1
Aliases CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting LAMP1 collected from DrugBank database.
> Drugs from DrugBank database
 

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