Summary | |
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Symbol | LAMP1 |
Name | lysosomal-associated membrane protein 1 |
Aliases | CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ...... |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Endosome membrane; Single-pass type I membrane protein Lysosome membrane Single-pass type I membrane protein Late endosome Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). |
Domain |
PF01299 Lysosome-associated membrane glycoprotein (Lamp) |
Function |
Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.; FUNCTION: Acts as a receptor for Lassa virus protein. |
Biological Process |
GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0001910 regulation of leukocyte mediated cytotoxicity GO:0001912 positive regulation of leukocyte mediated cytotoxicity GO:0002228 natural killer cell mediated immunity GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002323 natural killer cell activation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002703 regulation of leukocyte mediated immunity GO:0002705 positive regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002708 positive regulation of lymphocyte mediated immunity GO:0002715 regulation of natural killer cell mediated immunity GO:0002717 positive regulation of natural killer cell mediated immunity GO:0006887 exocytosis GO:0006892 post-Golgi vesicle-mediated transport GO:0006896 Golgi to vacuole transport GO:0006914 autophagy GO:0007018 microtubule-based movement GO:0007034 vacuolar transport GO:0007041 lysosomal transport GO:0008626 granzyme-mediated apoptotic signaling pathway GO:0010970 transport along microtubule GO:0016482 cytosolic transport GO:0017157 regulation of exocytosis GO:0019058 viral life cycle GO:0030101 natural killer cell activation GO:0030260 entry into host cell GO:0030705 cytoskeleton-dependent intracellular transport GO:0031341 regulation of cell killing GO:0031343 positive regulation of cell killing GO:0031349 positive regulation of defense response GO:0031647 regulation of protein stability GO:0032386 regulation of intracellular transport GO:0032814 regulation of natural killer cell activation GO:0032816 positive regulation of natural killer cell activation GO:0032886 regulation of microtubule-based process GO:0042267 natural killer cell mediated cytotoxicity GO:0042269 regulation of natural killer cell mediated cytotoxicity GO:0043299 leukocyte degranulation GO:0043300 regulation of leukocyte degranulation GO:0043302 positive regulation of leukocyte degranulation GO:0043320 natural killer cell degranulation GO:0043321 regulation of natural killer cell degranulation GO:0043323 positive regulation of natural killer cell degranulation GO:0044409 entry into host GO:0045055 regulated exocytosis GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045921 positive regulation of exocytosis GO:0045954 positive regulation of natural killer cell mediated cytotoxicity GO:0046718 viral entry into host cell GO:0048102 autophagic cell death GO:0048193 Golgi vesicle transport GO:0050821 protein stabilization GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0051047 positive regulation of secretion GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051640 organelle localization GO:0051656 establishment of organelle localization GO:0051701 interaction with host GO:0051806 entry into cell of other organism involved in symbiotic interaction GO:0051828 entry into other organism involved in symbiotic interaction GO:0060627 regulation of vesicle-mediated transport GO:0060632 regulation of microtubule-based movement GO:0072384 organelle transport along microtubule GO:0090160 Golgi to lysosome transport GO:1902513 regulation of organelle transport along microtubule GO:1903305 regulation of regulated secretory pathway GO:1903307 positive regulation of regulated secretory pathway GO:1903532 positive regulation of secretion by cell |
Molecular Function |
GO:0001618 virus receptor activity |
Cellular Component |
GO:0005765 lysosomal membrane GO:0005767 secondary lysosome GO:0005770 late endosome GO:0005771 multivesicular body GO:0008021 synaptic vesicle GO:0009897 external side of plasma membrane GO:0010008 endosome membrane GO:0030133 transport vesicle GO:0030139 endocytic vesicle GO:0030141 secretory granule GO:0030425 dendrite GO:0030659 cytoplasmic vesicle membrane GO:0030666 endocytic vesicle membrane GO:0030670 phagocytic vesicle membrane GO:0032010 phagolysosome GO:0042383 sarcolemma GO:0042470 melanosome GO:0042599 lamellar body GO:0043025 neuronal cell body GO:0044194 cytolytic granule GO:0044297 cell body GO:0044440 endosomal part GO:0045335 phagocytic vesicle GO:0048770 pigment granule GO:0061474 phagolysosome membrane GO:0070382 exocytic vesicle GO:0097208 alveolar lamellar body GO:0098552 side of membrane GO:0098793 presynapse GO:0098852 lytic vacuole membrane GO:0099503 secretory vesicle |
KEGG |
hsa04140 Regulation of autophagy hsa04142 Lysosome hsa04145 Phagosome |
Reactome |
R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation |
Summary | |
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Symbol | LAMP1 |
Name | lysosomal-associated membrane protein 1 |
Aliases | CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ...... |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LAMP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between LAMP1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | LAMP1 |
Name | lysosomal-associated membrane protein 1 |
Aliases | CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ...... |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LAMP1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LAMP1 |
Name | lysosomal-associated membrane protein 1 |
Aliases | CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ...... |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LAMP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of LAMP1 in various data sets.
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Summary | |
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Symbol | LAMP1 |
Name | lysosomal-associated membrane protein 1 |
Aliases | CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ...... |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LAMP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | LAMP1 |
Name | lysosomal-associated membrane protein 1 |
Aliases | CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ...... |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LAMP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LAMP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LAMP1 |
Name | lysosomal-associated membrane protein 1 |
Aliases | CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ...... |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LAMP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | LAMP1 |
Name | lysosomal-associated membrane protein 1 |
Aliases | CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ...... |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LAMP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | LAMP1 |
Name | lysosomal-associated membrane protein 1 |
Aliases | CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ...... |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LAMP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | LAMP1 |
Name | lysosomal-associated membrane protein 1 |
Aliases | CD107a; LAMPA; LGP120; CD107 antigen-like family member A; LAMP-1; lysosome-associated membrane protein 1; C ...... |
Chromosomal Location | 13q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LAMP1 collected from DrugBank database. |
There is no record. |