Summary | |
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Symbol | LAMTOR5 |
Name | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 |
Aliases | XIP; MGC71071; HBx-interacting protein; hepatitis B virus x-interacting protein (9.6kD); HBXIP; hepatitis B ...... |
Chromosomal Location | 1p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Lysosome. |
Domain |
PF16672 Ragulator complex protein LAMTOR5 |
Function |
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication. |
Biological Process |
GO:0001101 response to acid chemical GO:0006914 autophagy GO:0007050 cell cycle arrest GO:0008361 regulation of cell size GO:0009615 response to virus GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0016236 macroautophagy GO:0019058 viral life cycle GO:0019079 viral genome replication GO:0031929 TOR signaling GO:0032006 regulation of TOR signaling GO:0032008 positive regulation of TOR signaling GO:0032535 regulation of cellular component size GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043200 response to amino acid GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045786 negative regulation of cell cycle GO:0045861 negative regulation of proteolysis GO:0051346 negative regulation of hydrolase activity GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0061462 protein localization to lysosome GO:0071229 cellular response to acid chemical GO:0071230 cellular response to amino acid stimulus GO:0071417 cellular response to organonitrogen compound GO:0072665 protein localization to vacuole GO:0090066 regulation of anatomical structure size GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000117 negative regulation of cysteine-type endopeptidase activity |
Molecular Function |
GO:0005085 guanyl-nucleotide exchange factor activity GO:0032947 protein complex scaffold |
Cellular Component |
GO:0005765 lysosomal membrane GO:0005770 late endosome GO:0010008 endosome membrane GO:0031902 late endosome membrane GO:0044440 endosomal part GO:0045121 membrane raft GO:0071986 Ragulator complex GO:0098589 membrane region GO:0098852 lytic vacuole membrane GO:0098857 membrane microdomain |
KEGG |
hsa04150 mTOR signaling pathway |
Reactome |
R-HSA-2262752: Cellular responses to stress R-HSA-380972: Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-74751: Insulin receptor signalling cascade R-HSA-1632852: Macroautophagy R-HSA-109704: PI3K Cascade R-HSA-109703: PKB-mediated events R-HSA-162582: Signal Transduction R-HSA-74752: Signaling by Insulin receptor R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-5628897: TP53 Regulates Metabolic Genes R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-165159: mTOR signalling R-HSA-166208: mTORC1-mediated signalling |
Summary | |
---|---|
Symbol | LAMTOR5 |
Name | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 |
Aliases | XIP; MGC71071; HBx-interacting protein; hepatitis B virus x-interacting protein (9.6kD); HBXIP; hepatitis B ...... |
Chromosomal Location | 1p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LAMTOR5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | LAMTOR5 |
Name | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 |
Aliases | XIP; MGC71071; HBx-interacting protein; hepatitis B virus x-interacting protein (9.6kD); HBXIP; hepatitis B ...... |
Chromosomal Location | 1p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LAMTOR5 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | LAMTOR5 |
Name | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 |
Aliases | XIP; MGC71071; HBx-interacting protein; hepatitis B virus x-interacting protein (9.6kD); HBXIP; hepatitis B ...... |
Chromosomal Location | 1p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LAMTOR5 in various data sets.
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Points in the above scatter plot represent the mutation difference of LAMTOR5 in various data sets.
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Summary | |
---|---|
Symbol | LAMTOR5 |
Name | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 |
Aliases | XIP; MGC71071; HBx-interacting protein; hepatitis B virus x-interacting protein (9.6kD); HBXIP; hepatitis B ...... |
Chromosomal Location | 1p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LAMTOR5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | LAMTOR5 |
Name | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 |
Aliases | XIP; MGC71071; HBx-interacting protein; hepatitis B virus x-interacting protein (9.6kD); HBXIP; hepatitis B ...... |
Chromosomal Location | 1p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LAMTOR5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LAMTOR5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LAMTOR5 |
Name | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 |
Aliases | XIP; MGC71071; HBx-interacting protein; hepatitis B virus x-interacting protein (9.6kD); HBXIP; hepatitis B ...... |
Chromosomal Location | 1p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LAMTOR5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | LAMTOR5 |
Name | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 |
Aliases | XIP; MGC71071; HBx-interacting protein; hepatitis B virus x-interacting protein (9.6kD); HBXIP; hepatitis B ...... |
Chromosomal Location | 1p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LAMTOR5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | LAMTOR5 |
Name | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 |
Aliases | XIP; MGC71071; HBx-interacting protein; hepatitis B virus x-interacting protein (9.6kD); HBXIP; hepatitis B ...... |
Chromosomal Location | 1p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LAMTOR5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | LAMTOR5 |
Name | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 |
Aliases | XIP; MGC71071; HBx-interacting protein; hepatitis B virus x-interacting protein (9.6kD); HBXIP; hepatitis B ...... |
Chromosomal Location | 1p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LAMTOR5 collected from DrugBank database. |
There is no record. |