Summary | |
---|---|
Symbol | LBP |
Name | lipopolysaccharide binding protein |
Aliases | BPIFD2; BPI fold containing family D, member 2; lipopolysaccharide-binding protein; LPS-binding protein |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted Cytoplasmic granule membrane Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. |
Domain |
PF01273 LBP / BPI / CETP family PF02886 LBP / BPI / CETP family |
Function |
Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359). |
Biological Process |
GO:0001818 negative regulation of cytokine production GO:0001819 positive regulation of cytokine production GO:0002218 activation of innate immune response GO:0002221 pattern recognition receptor signaling pathway GO:0002224 toll-like receptor signaling pathway GO:0002232 leukocyte chemotaxis involved in inflammatory response GO:0002237 response to molecule of bacterial origin GO:0002263 cell activation involved in immune response GO:0002274 myeloid leukocyte activation GO:0002275 myeloid cell activation involved in immune response GO:0002281 macrophage activation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002523 leukocyte migration involved in inflammatory response GO:0002526 acute inflammatory response GO:0002532 production of molecular mediator involved in inflammatory response GO:0002536 respiratory burst involved in inflammatory response GO:0002679 respiratory burst involved in defense response GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0006869 lipid transport GO:0006909 phagocytosis GO:0006953 acute-phase response GO:0006968 cellular defense response GO:0008228 opsonization GO:0009595 detection of biotic stimulus GO:0010876 lipid localization GO:0015920 lipopolysaccharide transport GO:0030335 positive regulation of cell migration GO:0030593 neutrophil chemotaxis GO:0030595 leukocyte chemotaxis GO:0031349 positive regulation of defense response GO:0031663 lipopolysaccharide-mediated signaling pathway GO:0032103 positive regulation of response to external stimulus GO:0032490 detection of molecule of bacterial origin GO:0032496 response to lipopolysaccharide GO:0032602 chemokine production GO:0032635 interleukin-6 production GO:0032637 interleukin-8 production GO:0032640 tumor necrosis factor production GO:0032642 regulation of chemokine production GO:0032675 regulation of interleukin-6 production GO:0032677 regulation of interleukin-8 production GO:0032680 regulation of tumor necrosis factor production GO:0032720 negative regulation of tumor necrosis factor production GO:0032722 positive regulation of chemokine production GO:0032755 positive regulation of interleukin-6 production GO:0032757 positive regulation of interleukin-8 production GO:0032760 positive regulation of tumor necrosis factor production GO:0034121 regulation of toll-like receptor signaling pathway GO:0034123 positive regulation of toll-like receptor signaling pathway GO:0034142 toll-like receptor 4 signaling pathway GO:0034143 regulation of toll-like receptor 4 signaling pathway GO:0034145 positive regulation of toll-like receptor 4 signaling pathway GO:0040017 positive regulation of locomotion GO:0042035 regulation of cytokine biosynthetic process GO:0042089 cytokine biosynthetic process GO:0042107 cytokine metabolic process GO:0042108 positive regulation of cytokine biosynthetic process GO:0042116 macrophage activation GO:0042533 tumor necrosis factor biosynthetic process GO:0042534 regulation of tumor necrosis factor biosynthetic process GO:0042535 positive regulation of tumor necrosis factor biosynthetic process GO:0042742 defense response to bacterium GO:0043030 regulation of macrophage activation GO:0043032 positive regulation of macrophage activation GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044110 growth involved in symbiotic interaction GO:0044116 growth of symbiont involved in interaction with host GO:0044117 growth of symbiont in host GO:0044126 regulation of growth of symbiont in host GO:0044130 negative regulation of growth of symbiont in host GO:0044144 modulation of growth of symbiont involved in interaction with host GO:0044146 negative regulation of growth of symbiont involved in interaction with host GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045730 respiratory burst GO:0045926 negative regulation of growth GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050829 defense response to Gram-negative bacterium GO:0050830 defense response to Gram-positive bacterium GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051272 positive regulation of cellular component movement GO:0060263 regulation of respiratory burst GO:0060264 regulation of respiratory burst involved in inflammatory response GO:0060265 positive regulation of respiratory burst involved in inflammatory response GO:0060267 positive regulation of respiratory burst GO:0060326 cell chemotaxis GO:0070391 response to lipoteichoic acid GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071223 cellular response to lipoteichoic acid GO:0071396 cellular response to lipid GO:0071621 granulocyte chemotaxis GO:0071622 regulation of granulocyte chemotaxis GO:0071624 positive regulation of granulocyte chemotaxis GO:0071706 tumor necrosis factor superfamily cytokine production GO:0090022 regulation of neutrophil chemotaxis GO:0090023 positive regulation of neutrophil chemotaxis GO:0097529 myeloid leukocyte migration GO:0097530 granulocyte migration GO:0098542 defense response to other organism GO:0098581 detection of external biotic stimulus GO:1901264 carbohydrate derivative transport GO:1902622 regulation of neutrophil migration GO:1902624 positive regulation of neutrophil migration GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO:1990266 neutrophil migration GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0001530 lipopolysaccharide binding GO:0070891 lipoteichoic acid binding |
Cellular Component | - |
KEGG |
hsa04064 NF-kappa B signaling pathway hsa04620 Toll-like receptor signaling pathway |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-5686938: Regulation of TLR by endogenous ligand R-HSA-449147: Signaling by Interleukins R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade R-HSA-168898: Toll-Like Receptors Cascades R-HSA-166020: Transfer of LPS from LBP carrier to CD14 |
Summary | |
---|---|
Symbol | LBP |
Name | lipopolysaccharide binding protein |
Aliases | BPIFD2; BPI fold containing family D, member 2; lipopolysaccharide-binding protein; LPS-binding protein |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LBP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | LBP |
Name | lipopolysaccharide binding protein |
Aliases | BPIFD2; BPI fold containing family D, member 2; lipopolysaccharide-binding protein; LPS-binding protein |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LBP in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | LBP |
Name | lipopolysaccharide binding protein |
Aliases | BPIFD2; BPI fold containing family D, member 2; lipopolysaccharide-binding protein; LPS-binding protein |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LBP in various data sets.
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Points in the above scatter plot represent the mutation difference of LBP in various data sets.
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Summary | |
---|---|
Symbol | LBP |
Name | lipopolysaccharide binding protein |
Aliases | BPIFD2; BPI fold containing family D, member 2; lipopolysaccharide-binding protein; LPS-binding protein |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LBP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | LBP |
Name | lipopolysaccharide binding protein |
Aliases | BPIFD2; BPI fold containing family D, member 2; lipopolysaccharide-binding protein; LPS-binding protein |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LBP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LBP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | LBP |
Name | lipopolysaccharide binding protein |
Aliases | BPIFD2; BPI fold containing family D, member 2; lipopolysaccharide-binding protein; LPS-binding protein |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LBP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | LBP |
Name | lipopolysaccharide binding protein |
Aliases | BPIFD2; BPI fold containing family D, member 2; lipopolysaccharide-binding protein; LPS-binding protein |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LBP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | LBP |
Name | lipopolysaccharide binding protein |
Aliases | BPIFD2; BPI fold containing family D, member 2; lipopolysaccharide-binding protein; LPS-binding protein |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LBP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | LBP |
Name | lipopolysaccharide binding protein |
Aliases | BPIFD2; BPI fold containing family D, member 2; lipopolysaccharide-binding protein; LPS-binding protein |
Chromosomal Location | 20q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LBP collected from DrugBank database. |
There is no record. |