Summary | |
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Symbol | LBR |
Name | lamin B receptor |
Aliases | DHCR14B; TDRD18; tudor domain containing 18; LMN2R; PHA; integral nuclear envelope inner membrane protein; L ...... |
Chromosomal Location | 1q42.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus inner membrane; Multi-pass membrane protein. |
Domain |
PF01222 Ergosterol biosynthesis ERG4/ERG24 family PF09465 Lamin-B receptor of TUDOR domain |
Function |
Anchors the lamina and the heterochromatin to the inner nuclear membrane. |
Biological Process |
GO:0006066 alcohol metabolic process GO:0006694 steroid biosynthetic process GO:0006695 cholesterol biosynthetic process GO:0008202 steroid metabolic process GO:0008203 cholesterol metabolic process GO:0016125 sterol metabolic process GO:0016126 sterol biosynthetic process GO:0044283 small molecule biosynthetic process GO:0046165 alcohol biosynthetic process GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process GO:1902652 secondary alcohol metabolic process GO:1902653 secondary alcohol biosynthetic process |
Molecular Function |
GO:0005521 lamin binding GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor GO:0050613 delta14-sterol reductase activity GO:0070087 chromo shadow domain binding |
Cellular Component |
GO:0005635 nuclear envelope GO:0005637 nuclear inner membrane GO:0005639 integral component of nuclear inner membrane GO:0031229 intrinsic component of nuclear inner membrane GO:0031300 intrinsic component of organelle membrane GO:0031301 integral component of organelle membrane GO:0031965 nuclear membrane GO:0044453 nuclear membrane part |
KEGG | - |
Reactome |
R-HSA-191273: Cholesterol biosynthesis R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins |
Summary | |
---|---|
Symbol | LBR |
Name | lamin B receptor |
Aliases | DHCR14B; TDRD18; tudor domain containing 18; LMN2R; PHA; integral nuclear envelope inner membrane protein; L ...... |
Chromosomal Location | 1q42.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LBR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | LBR |
Name | lamin B receptor |
Aliases | DHCR14B; TDRD18; tudor domain containing 18; LMN2R; PHA; integral nuclear envelope inner membrane protein; L ...... |
Chromosomal Location | 1q42.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LBR in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LBR |
Name | lamin B receptor |
Aliases | DHCR14B; TDRD18; tudor domain containing 18; LMN2R; PHA; integral nuclear envelope inner membrane protein; L ...... |
Chromosomal Location | 1q42.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LBR in various data sets.
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Points in the above scatter plot represent the mutation difference of LBR in various data sets.
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Summary | |
---|---|
Symbol | LBR |
Name | lamin B receptor |
Aliases | DHCR14B; TDRD18; tudor domain containing 18; LMN2R; PHA; integral nuclear envelope inner membrane protein; L ...... |
Chromosomal Location | 1q42.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LBR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | LBR |
Name | lamin B receptor |
Aliases | DHCR14B; TDRD18; tudor domain containing 18; LMN2R; PHA; integral nuclear envelope inner membrane protein; L ...... |
Chromosomal Location | 1q42.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LBR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LBR. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LBR |
Name | lamin B receptor |
Aliases | DHCR14B; TDRD18; tudor domain containing 18; LMN2R; PHA; integral nuclear envelope inner membrane protein; L ...... |
Chromosomal Location | 1q42.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LBR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | LBR |
Name | lamin B receptor |
Aliases | DHCR14B; TDRD18; tudor domain containing 18; LMN2R; PHA; integral nuclear envelope inner membrane protein; L ...... |
Chromosomal Location | 1q42.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LBR expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | LBR |
Name | lamin B receptor |
Aliases | DHCR14B; TDRD18; tudor domain containing 18; LMN2R; PHA; integral nuclear envelope inner membrane protein; L ...... |
Chromosomal Location | 1q42.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LBR and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | LBR |
Name | lamin B receptor |
Aliases | DHCR14B; TDRD18; tudor domain containing 18; LMN2R; PHA; integral nuclear envelope inner membrane protein; L ...... |
Chromosomal Location | 1q42.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LBR collected from DrugBank database. |
There is no record. |