Browse LDB2

Summary
SymbolLDB2
NameLIM domain binding 2
Aliases LDB-2; LIM binding domain 2; LIM domain-binding factor CLIM1; LIM domain-binding factor-2; carboxyl-terminal ......
Chromosomal Location4p16
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF01803 LIM-domain binding protein
Function

Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors.

> Gene Ontology
 
Biological Process GO:0001894 tissue homeostasis
GO:0001942 hair follicle development
GO:0008544 epidermis development
GO:0010669 epithelial structure maintenance
GO:0019827 stem cell population maintenance
GO:0022404 molting cycle process
GO:0022405 hair cycle process
GO:0035019 somatic stem cell population maintenance
GO:0042303 molting cycle
GO:0042633 hair cycle
GO:0043588 skin development
GO:0044089 positive regulation of cellular component biogenesis
GO:0048871 multicellular organismal homeostasis
GO:0060249 anatomical structure homeostasis
GO:0098727 maintenance of cell number
GO:0098773 skin epidermis development
Molecular Function GO:0030274 LIM domain binding
Cellular Component GO:0005667 transcription factor complex
GO:0031252 cell leading edge
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolLDB2
NameLIM domain binding 2
Aliases LDB-2; LIM binding domain 2; LIM domain-binding factor CLIM1; LIM domain-binding factor-2; carboxyl-terminal ......
Chromosomal Location4p16
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between LDB2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolLDB2
NameLIM domain binding 2
Aliases LDB-2; LIM binding domain 2; LIM domain-binding factor CLIM1; LIM domain-binding factor-2; carboxyl-terminal ......
Chromosomal Location4p16
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of LDB2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolLDB2
NameLIM domain binding 2
Aliases LDB-2; LIM binding domain 2; LIM domain-binding factor CLIM1; LIM domain-binding factor-2; carboxyl-terminal ......
Chromosomal Location4p16
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of LDB2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.6610.0358
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.1770.29
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2830.736
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1950.607
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.010.995
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4320.844
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0720.869
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0480.965
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.190.885
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.0640.479
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.5310.214
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4770.000243
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of LDB2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.407.40.0709
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.407.40.096
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.516.7-4.21
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382710.5010.50.135
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161418.8018.80.228
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolLDB2
NameLIM domain binding 2
Aliases LDB-2; LIM binding domain 2; LIM domain-binding factor CLIM1; LIM domain-binding factor-2; carboxyl-terminal ......
Chromosomal Location4p16
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LDB2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolLDB2
NameLIM domain binding 2
Aliases LDB-2; LIM binding domain 2; LIM domain-binding factor CLIM1; LIM domain-binding factor-2; carboxyl-terminal ......
Chromosomal Location4p16
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LDB2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LDB2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolLDB2
NameLIM domain binding 2
Aliases LDB-2; LIM binding domain 2; LIM domain-binding factor CLIM1; LIM domain-binding factor-2; carboxyl-terminal ......
Chromosomal Location4p16
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LDB2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolLDB2
NameLIM domain binding 2
Aliases LDB-2; LIM binding domain 2; LIM domain-binding factor CLIM1; LIM domain-binding factor-2; carboxyl-terminal ......
Chromosomal Location4p16
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of LDB2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolLDB2
NameLIM domain binding 2
Aliases LDB-2; LIM binding domain 2; LIM domain-binding factor CLIM1; LIM domain-binding factor-2; carboxyl-terminal ......
Chromosomal Location4p16
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between LDB2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolLDB2
NameLIM domain binding 2
Aliases LDB-2; LIM binding domain 2; LIM domain-binding factor CLIM1; LIM domain-binding factor-2; carboxyl-terminal ......
Chromosomal Location4p16
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting LDB2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.