Summary | |
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Symbol | LDHA |
Name | lactate dehydrogenase A |
Aliases | GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. |
Domain |
PF02866 lactate/malate dehydrogenase PF00056 lactate/malate dehydrogenase |
Function |
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Biological Process |
GO:0000302 response to reactive oxygen species GO:0001666 response to hypoxia GO:0006089 lactate metabolic process GO:0006090 pyruvate metabolic process GO:0006091 generation of precursor metabolites and energy GO:0006096 glycolytic process GO:0006165 nucleoside diphosphate phosphorylation GO:0006732 coenzyme metabolic process GO:0006733 oxidoreduction coenzyme metabolic process GO:0006757 ATP generation from ADP GO:0006979 response to oxidative stress GO:0007584 response to nutrient GO:0009116 nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009123 nucleoside monophosphate metabolic process GO:0009126 purine nucleoside monophosphate metabolic process GO:0009132 nucleoside diphosphate metabolic process GO:0009135 purine nucleoside diphosphate metabolic process GO:0009141 nucleoside triphosphate metabolic process GO:0009144 purine nucleoside triphosphate metabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009161 ribonucleoside monophosphate metabolic process GO:0009167 purine ribonucleoside monophosphate metabolic process GO:0009179 purine ribonucleoside diphosphate metabolic process GO:0009185 ribonucleoside diphosphate metabolic process GO:0009199 ribonucleoside triphosphate metabolic process GO:0009205 purine ribonucleoside triphosphate metabolic process GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0009991 response to extracellular stimulus GO:0010035 response to inorganic substance GO:0014074 response to purine-containing compound GO:0016052 carbohydrate catabolic process GO:0019362 pyridine nucleotide metabolic process GO:0019674 NAD metabolic process GO:0031667 response to nutrient levels GO:0034284 response to monosaccharide GO:0036293 response to decreased oxygen levels GO:0042278 purine nucleoside metabolic process GO:0042493 response to drug GO:0042542 response to hydrogen peroxide GO:0043627 response to estrogen GO:0044723 single-organism carbohydrate metabolic process GO:0044724 single-organism carbohydrate catabolic process GO:0046031 ADP metabolic process GO:0046034 ATP metabolic process GO:0046128 purine ribonucleoside metabolic process GO:0046496 nicotinamide nucleotide metabolic process GO:0046683 response to organophosphorus GO:0046939 nucleotide phosphorylation GO:0048569 post-embryonic animal organ development GO:0051186 cofactor metabolic process GO:0051591 response to cAMP GO:0070482 response to oxygen levels GO:0072524 pyridine-containing compound metabolic process GO:1901657 glycosyl compound metabolic process |
Molecular Function |
GO:0004457 lactate dehydrogenase activity GO:0004459 L-lactate dehydrogenase activity GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0045296 cadherin binding GO:0048037 cofactor binding GO:0050662 coenzyme binding GO:0050839 cell adhesion molecule binding GO:0051287 NAD binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005913 cell-cell adherens junction |
KEGG |
hsa04066 HIF-1 signaling pathway hsa04922 Glucagon signaling pathway hsa00010 Glycolysis / Gluconeogenesis hsa00270 Cysteine and methionine metabolism hsa00620 Pyruvate metabolism hsa00640 Propanoate metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-1430728: Metabolism R-HSA-70268: Pyruvate metabolism R-HSA-71406: Pyruvate metabolism and Citric Acid (TCA) cycle R-HSA-1428517: The citric acid (TCA) cycle and respiratory electron transport |
Summary | |
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Symbol | LDHA |
Name | lactate dehydrogenase A |
Aliases | GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LDHA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between LDHA and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | LDHA |
Name | lactate dehydrogenase A |
Aliases | GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LDHA in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LDHA |
Name | lactate dehydrogenase A |
Aliases | GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LDHA in various data sets.
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Points in the above scatter plot represent the mutation difference of LDHA in various data sets.
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Summary | |
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Symbol | LDHA |
Name | lactate dehydrogenase A |
Aliases | GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LDHA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | LDHA |
Name | lactate dehydrogenase A |
Aliases | GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LDHA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LDHA. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LDHA |
Name | lactate dehydrogenase A |
Aliases | GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LDHA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | LDHA |
Name | lactate dehydrogenase A |
Aliases | GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LDHA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | LDHA |
Name | lactate dehydrogenase A |
Aliases | GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LDHA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | LDHA |
Name | lactate dehydrogenase A |
Aliases | GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LDHA collected from DrugBank database. |
Details on drugs targeting LDHA.
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