Browse LDHA

Summary
SymbolLDHA
Namelactate dehydrogenase A
Aliases GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm.
Domain PF02866 lactate/malate dehydrogenase
PF00056 lactate/malate dehydrogenase
Function

-

> Gene Ontology
 
Biological Process GO:0000302 response to reactive oxygen species
GO:0001666 response to hypoxia
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006096 glycolytic process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006732 coenzyme metabolic process
GO:0006733 oxidoreduction coenzyme metabolic process
GO:0006757 ATP generation from ADP
GO:0006979 response to oxidative stress
GO:0007584 response to nutrient
GO:0009116 nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009123 nucleoside monophosphate metabolic process
GO:0009126 purine nucleoside monophosphate metabolic process
GO:0009132 nucleoside diphosphate metabolic process
GO:0009135 purine nucleoside diphosphate metabolic process
GO:0009141 nucleoside triphosphate metabolic process
GO:0009144 purine nucleoside triphosphate metabolic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009161 ribonucleoside monophosphate metabolic process
GO:0009167 purine ribonucleoside monophosphate metabolic process
GO:0009179 purine ribonucleoside diphosphate metabolic process
GO:0009185 ribonucleoside diphosphate metabolic process
GO:0009199 ribonucleoside triphosphate metabolic process
GO:0009205 purine ribonucleoside triphosphate metabolic process
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009991 response to extracellular stimulus
GO:0010035 response to inorganic substance
GO:0014074 response to purine-containing compound
GO:0016052 carbohydrate catabolic process
GO:0019362 pyridine nucleotide metabolic process
GO:0019674 NAD metabolic process
GO:0031667 response to nutrient levels
GO:0034284 response to monosaccharide
GO:0036293 response to decreased oxygen levels
GO:0042278 purine nucleoside metabolic process
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043627 response to estrogen
GO:0044723 single-organism carbohydrate metabolic process
GO:0044724 single-organism carbohydrate catabolic process
GO:0046031 ADP metabolic process
GO:0046034 ATP metabolic process
GO:0046128 purine ribonucleoside metabolic process
GO:0046496 nicotinamide nucleotide metabolic process
GO:0046683 response to organophosphorus
GO:0046939 nucleotide phosphorylation
GO:0048569 post-embryonic animal organ development
GO:0051186 cofactor metabolic process
GO:0051591 response to cAMP
GO:0070482 response to oxygen levels
GO:0072524 pyridine-containing compound metabolic process
GO:1901657 glycosyl compound metabolic process
Molecular Function GO:0004457 lactate dehydrogenase activity
GO:0004459 L-lactate dehydrogenase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0045296 cadherin binding
GO:0048037 cofactor binding
GO:0050662 coenzyme binding
GO:0050839 cell adhesion molecule binding
GO:0051287 NAD binding
GO:0098631 protein binding involved in cell adhesion
GO:0098632 protein binding involved in cell-cell adhesion
GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component GO:0005913 cell-cell adherens junction
> KEGG and Reactome Pathway
 
KEGG hsa04066 HIF-1 signaling pathway
hsa04922 Glucagon signaling pathway
hsa00010 Glycolysis / Gluconeogenesis
hsa00270 Cysteine and methionine metabolism
hsa00620 Pyruvate metabolism
hsa00640 Propanoate metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-1430728: Metabolism
R-HSA-70268: Pyruvate metabolism
R-HSA-71406: Pyruvate metabolism and Citric Acid (TCA) cycle
R-HSA-1428517: The citric acid (TCA) cycle and respiratory electron transport
Summary
SymbolLDHA
Namelactate dehydrogenase A
Aliases GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between LDHA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between LDHA and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
27641098MelanomaInhibit immunity (T cell function)Elevated lactate dehydrogenase A (LDHA) expression is associated with poor outcome in tumor patients. Database analyses revealed negative correlations between LDHA expression and T cell activation markers in human melanoma patients.
28446465Lung CarcinomaInhibit immunity (T cell function)Our results suggest that expressions of LDH-A and lactate by macrophage in the tumor microenvironment are major drivers of T-cell immunosuppression, strongly supporting the concept of targeting stromal LDH-A as an effective strategy to blunt tumoral immune escape.
16837029Endometrial adenocarcinomaInhibit immunityEndometrial adenocarcinomas displayed LDH-5 expression in 31/68 (45.5%) cases with those having a high LDH-5 expression being connected with a low lymphocytic response; this may suggest an important role of LDH-5 and, presumably, lactate release in tumor escape from host immuno-surveillance.
Summary
SymbolLDHA
Namelactate dehydrogenase A
Aliases GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of LDHA in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolLDHA
Namelactate dehydrogenase A
Aliases GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of LDHA in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1580.639
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.5750.889
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1390.962
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.050.903
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4150.87
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.6380.844
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1710.78
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2890.916
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0240.993
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.150.962
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.3550.943
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1090.376
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of LDHA in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolLDHA
Namelactate dehydrogenase A
Aliases GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LDHA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolLDHA
Namelactate dehydrogenase A
Aliases GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LDHA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LDHA.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolLDHA
Namelactate dehydrogenase A
Aliases GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LDHA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolLDHA
Namelactate dehydrogenase A
Aliases GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of LDHA expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolLDHA
Namelactate dehydrogenase A
Aliases GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between LDHA and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolLDHA
Namelactate dehydrogenase A
Aliases GSD11; HEL-S-133P; LDHM; PIG19; LDH muscle subunit; LDH-A; LDH-M; cell proliferation-inducing gene 19 protei ......
Chromosomal Location11p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting LDHA collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting LDHA.
ID Name Drug Type Targets #Targets
DB00157NADHSmall MoleculeAASS, ACADS, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH7, AKR1B1, AKR1C1 ......144
DB02483Etheno-NadSmall MoleculeBST1, LDHA2
DB02701NicotinamideSmall MoleculeBST1, LDHA, PARP1, SIRT54
DB03940Oxamic AcidSmall MoleculeLDHA, LDHB2
DB09118StiripentolSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GA ......18
DB09130CopperSmall MoleculeA1BG, ACTG1, ACTN1, ACY1, AFM, AGT, AHCY, AHSG, AKR1A1, ANXA4, ANX ......141
DB11638ArtenimolSmall MoleculeACTG1, ALB, ALDH7A1, ALDOA, ANXA2, ATP5A1, ATP5L, ATP5O, CAST, CCT ......79