Summary | |
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Symbol | LEF1 |
Name | lymphoid enhancer-binding factor 1 |
Aliases | TCF1ALPHA; TCF10; TCF7L3; LEF-1; T cell-specific transcription factor 1-alpha; TCF1-alpha |
Chromosomal Location | 4q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Note=Found in nuclear bodies upon PIASG binding. |
Domain |
PF08347 N-terminal CTNNB1 binding PF00505 HMG (high mobility group) box |
Function |
Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. |
Biological Process |
GO:0001503 ossification GO:0001525 angiogenesis GO:0001558 regulation of cell growth GO:0001569 patterning of blood vessels GO:0001649 osteoblast differentiation GO:0001667 ameboidal-type cell migration GO:0001701 in utero embryonic development GO:0001704 formation of primary germ layer GO:0001707 mesoderm formation GO:0001755 neural crest cell migration GO:0001756 somitogenesis GO:0001763 morphogenesis of a branching structure GO:0001818 negative regulation of cytokine production GO:0001837 epithelial to mesenchymal transition GO:0001890 placenta development GO:0001892 embryonic placenta development GO:0002040 sprouting angiogenesis GO:0002065 columnar/cuboidal epithelial cell differentiation GO:0002200 somatic diversification of immune receptors GO:0002250 adaptive immune response GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002286 T cell activation involved in immune response GO:0002287 alpha-beta T cell activation involved in immune response GO:0002292 T cell differentiation involved in immune response GO:0002293 alpha-beta T cell differentiation involved in immune response GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002521 leukocyte differentiation GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus GO:0002568 somatic diversification of T cell receptor genes GO:0002573 myeloid leukocyte differentiation GO:0002681 somatic recombination of T cell receptor gene segments GO:0002761 regulation of myeloid leukocyte differentiation GO:0002763 positive regulation of myeloid leukocyte differentiation GO:0003002 regionalization GO:0006310 DNA recombination GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0007159 leukocyte cell-cell adhesion GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007223 Wnt signaling pathway, calcium modulating pathway GO:0007369 gastrulation GO:0007389 pattern specification process GO:0007405 neuroblast proliferation GO:0007423 sensory organ development GO:0007498 mesoderm development GO:0007517 muscle organ development GO:0009755 hormone-mediated signaling pathway GO:0009952 anterior/posterior pattern specification GO:0010001 glial cell differentiation GO:0010171 body morphogenesis GO:0010466 negative regulation of peptidase activity GO:0010717 regulation of epithelial to mesenchymal transition GO:0010718 positive regulation of epithelial to mesenchymal transition GO:0010951 negative regulation of endopeptidase activity GO:0014031 mesenchymal cell development GO:0014032 neural crest cell development GO:0014033 neural crest cell differentiation GO:0014706 striated muscle tissue development GO:0016049 cell growth GO:0016055 Wnt signaling pathway GO:0016202 regulation of striated muscle tissue development GO:0016444 somatic cell DNA recombination GO:0016570 histone modification GO:0016573 histone acetylation GO:0017145 stem cell division GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0019058 viral life cycle GO:0019080 viral gene expression GO:0019083 viral transcription GO:0021535 cell migration in hindbrain GO:0021536 diencephalon development GO:0021537 telencephalon development GO:0021542 dentate gyrus development GO:0021543 pallium development GO:0021761 limbic system development GO:0021766 hippocampus development GO:0021854 hypothalamus development GO:0021861 forebrain radial glial cell differentiation GO:0021872 forebrain generation of neurons GO:0021873 forebrain neuroblast division GO:0021879 forebrain neuron differentiation GO:0021932 hindbrain radial glia guided cell migration GO:0021943 formation of radial glial scaffolds GO:0021953 central nervous system neuron differentiation GO:0022407 regulation of cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030099 myeloid cell differentiation GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030217 T cell differentiation GO:0030223 neutrophil differentiation GO:0030307 positive regulation of cell growth GO:0030326 embryonic limb morphogenesis GO:0030335 positive regulation of cell migration GO:0030509 BMP signaling pathway GO:0030851 granulocyte differentiation GO:0030852 regulation of granulocyte differentiation GO:0030854 positive regulation of granulocyte differentiation GO:0030879 mammary gland development GO:0030900 forebrain development GO:0030902 hindbrain development GO:0032091 negative regulation of protein binding GO:0032616 interleukin-13 production GO:0032633 interleukin-4 production GO:0032634 interleukin-5 production GO:0032656 regulation of interleukin-13 production GO:0032673 regulation of interleukin-4 production GO:0032674 regulation of interleukin-5 production GO:0032696 negative regulation of interleukin-13 production GO:0032713 negative regulation of interleukin-4 production GO:0032714 negative regulation of interleukin-5 production GO:0032943 mononuclear cell proliferation GO:0033151 V(D)J recombination GO:0033153 T cell receptor V(D)J recombination GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0035239 tube morphogenesis GO:0035282 segmentation GO:0035567 non-canonical Wnt signaling pathway GO:0035710 CD4-positive, alpha-beta T cell activation GO:0035821 modification of morphology or physiology of other organism GO:0036445 neuronal stem cell division GO:0040017 positive regulation of locomotion GO:0042063 gliogenesis GO:0042088 T-helper 1 type immune response GO:0042093 T-helper cell differentiation GO:0042100 B cell proliferation GO:0042110 T cell activation GO:0042113 B cell activation GO:0042475 odontogenesis of dentin-containing tooth GO:0042476 odontogenesis GO:0042692 muscle cell differentiation GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043367 CD4-positive, alpha-beta T cell differentiation GO:0043392 negative regulation of DNA binding GO:0043393 regulation of protein binding GO:0043401 steroid hormone mediated signaling pathway GO:0043473 pigmentation GO:0043543 protein acylation GO:0043586 tongue development GO:0043900 regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0043921 modulation by host of viral transcription GO:0043923 positive regulation by host of viral transcription GO:0043966 histone H3 acetylation GO:0043967 histone H4 acetylation GO:0044033 multi-organism metabolic process GO:0045063 T-helper 1 cell differentiation GO:0045637 regulation of myeloid cell differentiation GO:0045639 positive regulation of myeloid cell differentiation GO:0045843 negative regulation of striated muscle tissue development GO:0045861 negative regulation of proteolysis GO:0045927 positive regulation of growth GO:0046631 alpha-beta T cell activation GO:0046632 alpha-beta T cell differentiation GO:0046651 lymphocyte proliferation GO:0046782 regulation of viral transcription GO:0048066 developmental pigmentation GO:0048069 eye pigmentation GO:0048103 somatic stem cell division GO:0048332 mesoderm morphogenesis GO:0048339 paraxial mesoderm development GO:0048340 paraxial mesoderm morphogenesis GO:0048341 paraxial mesoderm formation GO:0048514 blood vessel morphogenesis GO:0048524 positive regulation of viral process GO:0048545 response to steroid hormone GO:0048568 embryonic organ development GO:0048608 reproductive structure development GO:0048634 regulation of muscle organ development GO:0048635 negative regulation of muscle organ development GO:0048732 gland development GO:0048736 appendage development GO:0048747 muscle fiber development GO:0048754 branching morphogenesis of an epithelial tube GO:0048762 mesenchymal cell differentiation GO:0048863 stem cell differentiation GO:0048864 stem cell development GO:0050434 positive regulation of viral transcription GO:0050792 regulation of viral process GO:0050909 sensory perception of taste GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051101 regulation of DNA binding GO:0051146 striated muscle cell differentiation GO:0051272 positive regulation of cellular component movement GO:0051346 negative regulation of hydrolase activity GO:0051702 interaction with symbiont GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051851 modification by host of symbiont morphology or physiology GO:0052312 modulation of transcription in other organism involved in symbiotic interaction GO:0052472 modulation by host of symbiont transcription GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0055001 muscle cell development GO:0055002 striated muscle cell development GO:0055057 neuroblast division GO:0060019 radial glial cell differentiation GO:0060021 palate development GO:0060033 anatomical structure regression GO:0060070 canonical Wnt signaling pathway GO:0060173 limb development GO:0060323 head morphogenesis GO:0060324 face development GO:0060325 face morphogenesis GO:0060326 cell chemotaxis GO:0060438 trachea development GO:0060485 mesenchyme development GO:0060537 muscle tissue development GO:0060541 respiratory system development GO:0060561 apoptotic process involved in morphogenesis GO:0060562 epithelial tube morphogenesis GO:0060563 neuroepithelial cell differentiation GO:0060669 embryonic placenta morphogenesis GO:0060710 chorio-allantoic fusion GO:0060711 labyrinthine layer development GO:0060713 labyrinthine layer morphogenesis GO:0060828 regulation of canonical Wnt signaling pathway GO:0061053 somite development GO:0061138 morphogenesis of a branching epithelium GO:0061152 trachea submucosa development GO:0061153 trachea gland development GO:0061351 neural precursor cell proliferation GO:0061458 reproductive system development GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070670 response to interleukin-4 GO:0071353 cellular response to interleukin-4 GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071593 lymphocyte aggregation GO:0071772 response to BMP GO:0071773 cellular response to BMP stimulus GO:0071838 cell proliferation in bone marrow GO:0071839 apoptotic process in bone marrow GO:0071863 regulation of cell proliferation in bone marrow GO:0071864 positive regulation of cell proliferation in bone marrow GO:0071865 regulation of apoptotic process in bone marrow GO:0071866 negative regulation of apoptotic process in bone marrow GO:0071895 odontoblast differentiation GO:0071898 regulation of estrogen receptor binding GO:0071899 negative regulation of estrogen receptor binding GO:0072089 stem cell proliferation GO:0072132 mesenchyme morphogenesis GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0198738 cell-cell signaling by wnt GO:1900120 regulation of receptor binding GO:1900121 negative regulation of receptor binding GO:1901861 regulation of muscle tissue development GO:1901862 negative regulation of muscle tissue development GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1902262 apoptotic process involved in patterning of blood vessels GO:1902742 apoptotic process involved in development GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1903900 regulation of viral life cycle GO:1903902 positive regulation of viral life cycle GO:1904837 beta-catenin-TCF complex assembly GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000117 negative regulation of cysteine-type endopeptidase activity GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003707 steroid hormone receptor activity GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0004869 cysteine-type endopeptidase inhibitor activity GO:0008013 beta-catenin binding GO:0008134 transcription factor binding GO:0008301 DNA binding, bending GO:0030284 estrogen receptor activity GO:0030331 estrogen receptor binding GO:0030414 peptidase inhibitor activity GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0035326 enhancer binding GO:0042393 histone binding GO:0042826 histone deacetylase binding GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process GO:0045295 gamma-catenin binding GO:0051427 hormone receptor binding GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity GO:0070016 armadillo repeat domain binding GO:0070742 C2H2 zinc finger domain binding |
Cellular Component |
GO:0005667 transcription factor complex GO:0032993 protein-DNA complex GO:0044798 nuclear transcription factor complex GO:0090575 RNA polymerase II transcription factor complex GO:1990907 beta-catenin-TCF complex |
KEGG |
hsa04310 Wnt signaling pathway hsa04390 Hippo signaling pathway hsa04520 Adherens junction hsa04916 Melanogenesis |
Reactome |
R-HSA-3858494: Beta-catenin independent WNT signaling R-HSA-4411364: Binding of TCF/LEF R-HSA-4086398: Ca2+ pathway R-HSA-3769402: Deactivation of the beta-catenin transactivating complex R-HSA-195253: Degradation of beta-catenin by the destruction complex R-HSA-201722: Formation of the beta-catenin R-HSA-4641265: Repression of WNT target genes R-HSA-162582: Signal Transduction R-HSA-195721: Signaling by Wnt R-HSA-201681: TCF dependent signaling in response to WNT |
Summary | |
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Symbol | LEF1 |
Name | lymphoid enhancer-binding factor 1 |
Aliases | TCF1ALPHA; TCF10; TCF7L3; LEF-1; T cell-specific transcription factor 1-alpha; TCF1-alpha |
Chromosomal Location | 4q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LEF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between LEF1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | LEF1 |
Name | lymphoid enhancer-binding factor 1 |
Aliases | TCF1ALPHA; TCF10; TCF7L3; LEF-1; T cell-specific transcription factor 1-alpha; TCF1-alpha |
Chromosomal Location | 4q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LEF1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LEF1 |
Name | lymphoid enhancer-binding factor 1 |
Aliases | TCF1ALPHA; TCF10; TCF7L3; LEF-1; T cell-specific transcription factor 1-alpha; TCF1-alpha |
Chromosomal Location | 4q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LEF1 in various data sets.
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Points in the above scatter plot represent the mutation difference of LEF1 in various data sets.
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Summary | |
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Symbol | LEF1 |
Name | lymphoid enhancer-binding factor 1 |
Aliases | TCF1ALPHA; TCF10; TCF7L3; LEF-1; T cell-specific transcription factor 1-alpha; TCF1-alpha |
Chromosomal Location | 4q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LEF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | LEF1 |
Name | lymphoid enhancer-binding factor 1 |
Aliases | TCF1ALPHA; TCF10; TCF7L3; LEF-1; T cell-specific transcription factor 1-alpha; TCF1-alpha |
Chromosomal Location | 4q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LEF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LEF1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LEF1 |
Name | lymphoid enhancer-binding factor 1 |
Aliases | TCF1ALPHA; TCF10; TCF7L3; LEF-1; T cell-specific transcription factor 1-alpha; TCF1-alpha |
Chromosomal Location | 4q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LEF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | LEF1 |
Name | lymphoid enhancer-binding factor 1 |
Aliases | TCF1ALPHA; TCF10; TCF7L3; LEF-1; T cell-specific transcription factor 1-alpha; TCF1-alpha |
Chromosomal Location | 4q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LEF1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | LEF1 |
Name | lymphoid enhancer-binding factor 1 |
Aliases | TCF1ALPHA; TCF10; TCF7L3; LEF-1; T cell-specific transcription factor 1-alpha; TCF1-alpha |
Chromosomal Location | 4q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LEF1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | LEF1 |
Name | lymphoid enhancer-binding factor 1 |
Aliases | TCF1ALPHA; TCF10; TCF7L3; LEF-1; T cell-specific transcription factor 1-alpha; TCF1-alpha |
Chromosomal Location | 4q23-q25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LEF1 collected from DrugBank database. |
Details on drugs targeting LEF1.
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