Summary | |
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Symbol | LGALS1 |
Name | lectin, galactoside-binding, soluble, 1 |
Aliases | galectin 1; GAL1; 14 kDa laminin-binding protein; 14 kDa lectin; HBL; HLBP14; HPL; S-Lac lectin 1; beta-gala ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix |
Domain |
PF00337 Galactoside-binding lectin |
Function |
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. |
Biological Process |
GO:0001678 cellular glucose homeostasis GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002312 B cell activation involved in immune response GO:0002313 mature B cell differentiation involved in immune response GO:0002317 plasma cell differentiation GO:0002335 mature B cell differentiation GO:0002366 leukocyte activation involved in immune response GO:0002521 leukocyte differentiation GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0010721 negative regulation of cell development GO:0010810 regulation of cell-substrate adhesion GO:0010812 negative regulation of cell-substrate adhesion GO:0010975 regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0019058 viral life cycle GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030183 B cell differentiation GO:0030260 entry into host cell GO:0031294 lymphocyte costimulation GO:0031295 T cell costimulation GO:0031345 negative regulation of cell projection organization GO:0031589 cell-substrate adhesion GO:0033500 carbohydrate homeostasis GO:0033555 multicellular organismal response to stress GO:0034109 homotypic cell-cell adhesion GO:0034110 regulation of homotypic cell-cell adhesion GO:0034112 positive regulation of homotypic cell-cell adhesion GO:0034117 erythrocyte aggregation GO:0034118 regulation of erythrocyte aggregation GO:0034120 positive regulation of erythrocyte aggregation GO:0034284 response to monosaccharide GO:0042110 T cell activation GO:0042113 B cell activation GO:0042493 response to drug GO:0042593 glucose homeostasis GO:0042692 muscle cell differentiation GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043900 regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044409 entry into host GO:0045445 myoblast differentiation GO:0045665 negative regulation of neuron differentiation GO:0045785 positive regulation of cell adhesion GO:0046596 regulation of viral entry into host cell GO:0046598 positive regulation of viral entry into host cell GO:0046718 viral entry into host cell GO:0048524 positive regulation of viral process GO:0048678 response to axon injury GO:0050768 negative regulation of neurogenesis GO:0050792 regulation of viral process GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051701 interaction with host GO:0051806 entry into cell of other organism involved in symbiotic interaction GO:0051828 entry into other organism involved in symbiotic interaction GO:0051961 negative regulation of nervous system development GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071322 cellular response to carbohydrate stimulus GO:0071326 cellular response to monosaccharide stimulus GO:0071331 cellular response to hexose stimulus GO:0071333 cellular response to glucose stimulus GO:0071407 cellular response to organic cyclic compound GO:0071593 lymphocyte aggregation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903900 regulation of viral life cycle GO:1903902 positive regulation of viral life cycle |
Molecular Function |
GO:0001948 glycoprotein binding GO:0030246 carbohydrate binding GO:0030395 lactose binding GO:0043236 laminin binding GO:0048030 disaccharide binding GO:0050840 extracellular matrix binding GO:0070492 oligosaccharide binding |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | LGALS1 |
Name | lectin, galactoside-binding, soluble, 1 |
Aliases | galectin 1; GAL1; 14 kDa laminin-binding protein; 14 kDa lectin; HBL; HLBP14; HPL; S-Lac lectin 1; beta-gala ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LGALS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between LGALS1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | LGALS1 |
Name | lectin, galactoside-binding, soluble, 1 |
Aliases | galectin 1; GAL1; 14 kDa laminin-binding protein; 14 kDa lectin; HBL; HLBP14; HPL; S-Lac lectin 1; beta-gala ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LGALS1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LGALS1 |
Name | lectin, galactoside-binding, soluble, 1 |
Aliases | galectin 1; GAL1; 14 kDa laminin-binding protein; 14 kDa lectin; HBL; HLBP14; HPL; S-Lac lectin 1; beta-gala ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LGALS1 in various data sets.
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There is no record. |
Summary | |
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Symbol | LGALS1 |
Name | lectin, galactoside-binding, soluble, 1 |
Aliases | galectin 1; GAL1; 14 kDa laminin-binding protein; 14 kDa lectin; HBL; HLBP14; HPL; S-Lac lectin 1; beta-gala ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LGALS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | LGALS1 |
Name | lectin, galactoside-binding, soluble, 1 |
Aliases | galectin 1; GAL1; 14 kDa laminin-binding protein; 14 kDa lectin; HBL; HLBP14; HPL; S-Lac lectin 1; beta-gala ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LGALS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LGALS1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LGALS1 |
Name | lectin, galactoside-binding, soluble, 1 |
Aliases | galectin 1; GAL1; 14 kDa laminin-binding protein; 14 kDa lectin; HBL; HLBP14; HPL; S-Lac lectin 1; beta-gala ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LGALS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | LGALS1 |
Name | lectin, galactoside-binding, soluble, 1 |
Aliases | galectin 1; GAL1; 14 kDa laminin-binding protein; 14 kDa lectin; HBL; HLBP14; HPL; S-Lac lectin 1; beta-gala ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LGALS1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | LGALS1 |
Name | lectin, galactoside-binding, soluble, 1 |
Aliases | galectin 1; GAL1; 14 kDa laminin-binding protein; 14 kDa lectin; HBL; HLBP14; HPL; S-Lac lectin 1; beta-gala ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LGALS1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | LGALS1 |
Name | lectin, galactoside-binding, soluble, 1 |
Aliases | galectin 1; GAL1; 14 kDa laminin-binding protein; 14 kDa lectin; HBL; HLBP14; HPL; S-Lac lectin 1; beta-gala ...... |
Chromosomal Location | 22q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LGALS1 collected from DrugBank database. |
Details on drugs targeting LGALS1.
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