Summary | |
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Symbol | LGALS3 |
Name | lectin, galactoside-binding, soluble, 3 |
Aliases | MAC-2; GALIG; galectin 3; CBP35; GAL3; GALBP; MAC2; 35 kDa lectin; IgE-binding protein; MAC-2 antigen; carbo ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. Secreted. Note=Secreted by a non-classical secretory pathway and associates with the cell surface. |
Domain |
PF00337 Galactoside-binding lectin |
Function |
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. |
Biological Process |
GO:0001771 immunological synapse formation GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002286 T cell activation involved in immune response GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002366 leukocyte activation involved in immune response GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002548 monocyte chemotaxis GO:0002683 negative regulation of immune system process GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002698 negative regulation of immune effector process GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0006397 mRNA processing GO:0006816 calcium ion transport GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0008037 cell recognition GO:0008380 RNA splicing GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0009988 cell-cell recognition GO:0010959 regulation of metal ion transport GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0030100 regulation of endocytosis GO:0030335 positive regulation of cell migration GO:0030593 neutrophil chemotaxis GO:0030595 leukocyte chemotaxis GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0040017 positive regulation of locomotion GO:0042098 T cell proliferation GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0043270 positive regulation of ion transport GO:0045806 negative regulation of endocytosis GO:0046651 lymphocyte proliferation GO:0048245 eosinophil chemotaxis GO:0048246 macrophage chemotaxis GO:0050670 regulation of lymphocyte proliferation GO:0050777 negative regulation of immune response GO:0050851 antigen receptor-mediated signaling pathway GO:0050852 T cell receptor signaling pathway GO:0050854 regulation of antigen receptor-mediated signaling pathway GO:0050856 regulation of T cell receptor signaling pathway GO:0050858 negative regulation of antigen receptor-mediated signaling pathway GO:0050860 negative regulation of T cell receptor signaling pathway GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050868 negative regulation of T cell activation GO:0050900 leukocyte migration GO:0050918 positive chemotaxis GO:0051051 negative regulation of transport GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051272 positive regulation of cellular component movement GO:0051924 regulation of calcium ion transport GO:0051928 positive regulation of calcium ion transport GO:0060326 cell chemotaxis GO:0060627 regulation of vesicle-mediated transport GO:0070227 lymphocyte apoptotic process GO:0070228 regulation of lymphocyte apoptotic process GO:0070231 T cell apoptotic process GO:0070232 regulation of T cell apoptotic process GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070509 calcium ion import GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070838 divalent metal ion transport GO:0071593 lymphocyte aggregation GO:0071621 granulocyte chemotaxis GO:0071674 mononuclear cell migration GO:0071675 regulation of mononuclear cell migration GO:0071677 positive regulation of mononuclear cell migration GO:0071887 leukocyte apoptotic process GO:0072511 divalent inorganic cation transport GO:0072677 eosinophil migration GO:0090279 regulation of calcium ion import GO:0090280 positive regulation of calcium ion import GO:0097191 extrinsic apoptotic signaling pathway GO:0097529 myeloid leukocyte migration GO:0097530 granulocyte migration GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903038 negative regulation of leukocyte cell-cell adhesion GO:1990266 neutrophil migration GO:2000106 regulation of leukocyte apoptotic process GO:2000147 positive regulation of cell motility GO:2000520 regulation of immunological synapse formation GO:2000521 negative regulation of immunological synapse formation GO:2001188 regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:2001189 negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway |
Molecular Function |
GO:0019863 IgE binding GO:0019865 immunoglobulin binding GO:0030246 carbohydrate binding GO:0042056 chemoattractant activity GO:0043236 laminin binding GO:0050840 extracellular matrix binding |
Cellular Component |
GO:0001772 immunological synapse GO:0005681 spliceosomal complex GO:0005743 mitochondrial inner membrane |
KEGG | - |
Reactome |
R-HSA-879415: Advanced glycosylation endproduct receptor signaling R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation |
Summary | |
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Symbol | LGALS3 |
Name | lectin, galactoside-binding, soluble, 3 |
Aliases | MAC-2; GALIG; galectin 3; CBP35; GAL3; GALBP; MAC2; 35 kDa lectin; IgE-binding protein; MAC-2 antigen; carbo ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LGALS3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between LGALS3 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | LGALS3 |
Name | lectin, galactoside-binding, soluble, 3 |
Aliases | MAC-2; GALIG; galectin 3; CBP35; GAL3; GALBP; MAC2; 35 kDa lectin; IgE-binding protein; MAC-2 antigen; carbo ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LGALS3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LGALS3 |
Name | lectin, galactoside-binding, soluble, 3 |
Aliases | MAC-2; GALIG; galectin 3; CBP35; GAL3; GALBP; MAC2; 35 kDa lectin; IgE-binding protein; MAC-2 antigen; carbo ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LGALS3 in various data sets.
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Points in the above scatter plot represent the mutation difference of LGALS3 in various data sets.
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Summary | |
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Symbol | LGALS3 |
Name | lectin, galactoside-binding, soluble, 3 |
Aliases | MAC-2; GALIG; galectin 3; CBP35; GAL3; GALBP; MAC2; 35 kDa lectin; IgE-binding protein; MAC-2 antigen; carbo ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LGALS3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | LGALS3 |
Name | lectin, galactoside-binding, soluble, 3 |
Aliases | MAC-2; GALIG; galectin 3; CBP35; GAL3; GALBP; MAC2; 35 kDa lectin; IgE-binding protein; MAC-2 antigen; carbo ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LGALS3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LGALS3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LGALS3 |
Name | lectin, galactoside-binding, soluble, 3 |
Aliases | MAC-2; GALIG; galectin 3; CBP35; GAL3; GALBP; MAC2; 35 kDa lectin; IgE-binding protein; MAC-2 antigen; carbo ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LGALS3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | LGALS3 |
Name | lectin, galactoside-binding, soluble, 3 |
Aliases | MAC-2; GALIG; galectin 3; CBP35; GAL3; GALBP; MAC2; 35 kDa lectin; IgE-binding protein; MAC-2 antigen; carbo ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LGALS3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | LGALS3 |
Name | lectin, galactoside-binding, soluble, 3 |
Aliases | MAC-2; GALIG; galectin 3; CBP35; GAL3; GALBP; MAC2; 35 kDa lectin; IgE-binding protein; MAC-2 antigen; carbo ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LGALS3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | LGALS3 |
Name | lectin, galactoside-binding, soluble, 3 |
Aliases | MAC-2; GALIG; galectin 3; CBP35; GAL3; GALBP; MAC2; 35 kDa lectin; IgE-binding protein; MAC-2 antigen; carbo ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LGALS3 collected from DrugBank database. |
Details on drugs targeting LGALS3.
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