TISIDB

Summary
Symbol	LGALS3BP
Name	lectin, galactoside-binding, soluble, 3 binding protein
Aliases	MAC-2-BP; 90K; BTBD17B; TANGO10B; M2BP; gp90; CyCAP; L3 antigen; Mac-2-binding protein; serum protein 90K; t ......
Chromosomal Location	17q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Secreted Secreted, extracellular space, extracellular matrix
Domain	PF07707 BTB And C-terminal Kelch PF00530 Scavenger receptor cysteine-rich domain
Function	Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.

> Gene Ontology [ TOP ]
Biological Process	GO:0002576 platelet degranulation GO:0006887 exocytosis GO:0006898 receptor-mediated endocytosis GO:0006968 cellular defense response GO:0045055 regulated exocytosis
Molecular Function	GO:0005044 scavenger receptor activity GO:0038024 cargo receptor activity
Cellular Component	GO:0005578 proteinaceous extracellular matrix GO:0030141 secretory granule GO:0031089 platelet dense granule lumen GO:0031983 vesicle lumen GO:0034774 secretory granule lumen GO:0042827 platelet dense granule GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0072562 blood microparticle GO:0099503 secretory vesicle

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-109582: Hemostasis R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-114608: Platelet degranulation R-HSA-76005: Response to elevated platelet cytosolic Ca2+

Summary
Symbol	LGALS3BP
Name	lectin, galactoside-binding, soluble, 3 binding protein
Aliases	MAC-2-BP; 90K; BTBD17B; TANGO10B; M2BP; gp90; CyCAP; L3 antigen; Mac-2-binding protein; serum protein 90K; t ......
Chromosomal Location	17q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between LGALS3BP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between LGALS3BP and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
25315772	Colorectal Carcinoma; Prostate Carcinoma	Inhibit immunity	These findings suggest a novel immunoinhibitory function for LGALS3BP that might be important for immune evasion of tumor cells during cancer progression.
20581239	Colorectal Carcinoma	Promote immunity	Secreted 90K suppresses CRC cell invasion, but this action of 90K is masked through binding with extracellular galectins. In a syngeneic mouse colon tumour model, tumour growth and lung metastasis were increased with 90K knockdown. 90K itself has antitumour activity in CRC cells via suppression of Wnt signalling with a novel mechanism of ISGylation-dependent ubiquitination of beta-catenin when it interacts with CD9/CD82, but is downregulated in advanced CRC tissues.
16204073	Colon Adenocarcinoma	Promote immunity	Overexpression of 90K in CT-26/antisense KITENIN cells further delayed tumor growth compared with that of CT-26/antisense KITENIN cells.

Summary
Symbol	LGALS3BP
Name	lectin, galactoside-binding, soluble, 3 binding protein
Aliases	MAC-2-BP; 90K; BTBD17B; TANGO10B; M2BP; gp90; CyCAP; L3 antigen; Mac-2-binding protein; serum protein 90K; t ......
Chromosomal Location	17q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of LGALS3BP in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	LGALS3BP
Name	lectin, galactoside-binding, soluble, 3 binding protein
Aliases	MAC-2-BP; 90K; BTBD17B; TANGO10B; M2BP; gp90; CyCAP; L3 antigen; Mac-2-binding protein; serum protein 90K; t ......
Chromosomal Location	17q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of LGALS3BP in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.306	0.504
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.138	0.973
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.433	0.883
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.656	0.211
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.703	0.802
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.592	0.864
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.217	0.724
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.036	0.988
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.27	0.923
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.243	0.927
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.264	0.949
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.003	0.979

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of LGALS3BP in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	4.1	-0.4	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	5.1	-1.4	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	3.7	-3.7	0.415
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	7.7	-7.7	0.371
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	LGALS3BP
Name	lectin, galactoside-binding, soluble, 3 binding protein
Aliases	MAC-2-BP; 90K; BTBD17B; TANGO10B; M2BP; gp90; CyCAP; L3 antigen; Mac-2-binding protein; serum protein 90K; t ......
Chromosomal Location	17q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LGALS3BP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	LGALS3BP
Name	lectin, galactoside-binding, soluble, 3 binding protein
Aliases	MAC-2-BP; 90K; BTBD17B; TANGO10B; M2BP; gp90; CyCAP; L3 antigen; Mac-2-binding protein; serum protein 90K; t ......
Chromosomal Location	17q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LGALS3BP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LGALS3BP. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	LGALS3BP
Name	lectin, galactoside-binding, soluble, 3 binding protein
Aliases	MAC-2-BP; 90K; BTBD17B; TANGO10B; M2BP; gp90; CyCAP; L3 antigen; Mac-2-binding protein; serum protein 90K; t ......
Chromosomal Location	17q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LGALS3BP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	LGALS3BP
Name	lectin, galactoside-binding, soluble, 3 binding protein
Aliases	MAC-2-BP; 90K; BTBD17B; TANGO10B; M2BP; gp90; CyCAP; L3 antigen; Mac-2-binding protein; serum protein 90K; t ......
Chromosomal Location	17q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of LGALS3BP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	LGALS3BP
Name	lectin, galactoside-binding, soluble, 3 binding protein
Aliases	MAC-2-BP; 90K; BTBD17B; TANGO10B; M2BP; gp90; CyCAP; L3 antigen; Mac-2-binding protein; serum protein 90K; t ......
Chromosomal Location	17q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between LGALS3BP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	LGALS3BP
Name	lectin, galactoside-binding, soluble, 3 binding protein
Aliases	MAC-2-BP; 90K; BTBD17B; TANGO10B; M2BP; gp90; CyCAP; L3 antigen; Mac-2-binding protein; serum protein 90K; t ......
Chromosomal Location	17q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting LGALS3BP collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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