Summary | |
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Symbol | LHX2 |
Name | LIM homeobox 2 |
Aliases | LH-2; hLhx2; LIM HOX gene 2; LIM homeobox protein 2; homeobox protein LH-2; LIM/homeobox protein Lhx2 |
Chromosomal Location | 9q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00046 Homeobox domain PF00412 LIM domain |
Function |
Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity). |
Biological Process |
GO:0001654 eye development GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0001843 neural tube closure GO:0001942 hair follicle development GO:0003002 regionalization GO:0007163 establishment or maintenance of cell polarity GO:0007389 pattern specification process GO:0007409 axonogenesis GO:0007411 axon guidance GO:0007423 sensory organ development GO:0007498 mesoderm development GO:0008544 epidermis development GO:0009953 dorsal/ventral pattern formation GO:0014020 primary neural tube formation GO:0016049 cell growth GO:0016331 morphogenesis of embryonic epithelium GO:0021537 telencephalon development GO:0021543 pallium development GO:0021772 olfactory bulb development GO:0021871 forebrain regionalization GO:0021915 neural tube development GO:0021978 telencephalon regionalization GO:0021987 cerebral cortex development GO:0021988 olfactory lobe development GO:0022404 molting cycle process GO:0022405 hair cycle process GO:0030011 maintenance of cell polarity GO:0030900 forebrain development GO:0035088 establishment or maintenance of apical/basal cell polarity GO:0035090 maintenance of apical/basal cell polarity GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0042303 molting cycle GO:0042633 hair cycle GO:0043010 camera-type eye development GO:0043392 negative regulation of DNA binding GO:0043588 skin development GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity GO:0045199 maintenance of epithelial cell apical/basal polarity GO:0048588 developmental cell growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048675 axon extension GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051101 regulation of DNA binding GO:0060041 retina development in camera-type eye GO:0060560 developmental growth involved in morphogenesis GO:0060562 epithelial tube morphogenesis GO:0060606 tube closure GO:0061245 establishment or maintenance of bipolar cell polarity GO:0061564 axon development GO:0072175 epithelial tube formation GO:0097485 neuron projection guidance GO:0098773 skin epidermis development GO:1990138 neuron projection extension GO:2000677 regulation of transcription regulatory region DNA binding GO:2000678 negative regulation of transcription regulatory region DNA binding |
Molecular Function |
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0003682 chromatin binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | LHX2 |
Name | LIM homeobox 2 |
Aliases | LH-2; hLhx2; LIM HOX gene 2; LIM homeobox protein 2; homeobox protein LH-2; LIM/homeobox protein Lhx2 |
Chromosomal Location | 9q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LHX2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | LHX2 |
Name | LIM homeobox 2 |
Aliases | LH-2; hLhx2; LIM HOX gene 2; LIM homeobox protein 2; homeobox protein LH-2; LIM/homeobox protein Lhx2 |
Chromosomal Location | 9q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LHX2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LHX2 |
Name | LIM homeobox 2 |
Aliases | LH-2; hLhx2; LIM HOX gene 2; LIM homeobox protein 2; homeobox protein LH-2; LIM/homeobox protein Lhx2 |
Chromosomal Location | 9q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LHX2 in various data sets.
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Points in the above scatter plot represent the mutation difference of LHX2 in various data sets.
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Summary | |
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Symbol | LHX2 |
Name | LIM homeobox 2 |
Aliases | LH-2; hLhx2; LIM HOX gene 2; LIM homeobox protein 2; homeobox protein LH-2; LIM/homeobox protein Lhx2 |
Chromosomal Location | 9q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LHX2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | LHX2 |
Name | LIM homeobox 2 |
Aliases | LH-2; hLhx2; LIM HOX gene 2; LIM homeobox protein 2; homeobox protein LH-2; LIM/homeobox protein Lhx2 |
Chromosomal Location | 9q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LHX2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LHX2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LHX2 |
Name | LIM homeobox 2 |
Aliases | LH-2; hLhx2; LIM HOX gene 2; LIM homeobox protein 2; homeobox protein LH-2; LIM/homeobox protein Lhx2 |
Chromosomal Location | 9q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LHX2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | LHX2 |
Name | LIM homeobox 2 |
Aliases | LH-2; hLhx2; LIM HOX gene 2; LIM homeobox protein 2; homeobox protein LH-2; LIM/homeobox protein Lhx2 |
Chromosomal Location | 9q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LHX2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | LHX2 |
Name | LIM homeobox 2 |
Aliases | LH-2; hLhx2; LIM HOX gene 2; LIM homeobox protein 2; homeobox protein LH-2; LIM/homeobox protein Lhx2 |
Chromosomal Location | 9q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LHX2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | LHX2 |
Name | LIM homeobox 2 |
Aliases | LH-2; hLhx2; LIM HOX gene 2; LIM homeobox protein 2; homeobox protein LH-2; LIM/homeobox protein Lhx2 |
Chromosomal Location | 9q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LHX2 collected from DrugBank database. |
There is no record. |