Summary | |
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Symbol | LHX4 |
Name | LIM homeobox 4 |
Aliases | Gsh4; CPHD4; LIM homeobox protein 4; LIM/homeobox protein Lhx4 |
Chromosomal Location | 1q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00046 Homeobox domain PF00412 LIM domain |
Function |
May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (PubMed:28473536). |
Biological Process |
GO:0001890 placenta development GO:0007409 axonogenesis GO:0007411 axon guidance GO:0008045 motor neuron axon guidance GO:0021510 spinal cord development GO:0021515 cell differentiation in spinal cord GO:0021517 ventral spinal cord development GO:0021522 spinal cord motor neuron differentiation GO:0021523 somatic motor neuron differentiation GO:0021526 medial motor column neuron differentiation GO:0021953 central nervous system neuron differentiation GO:0048608 reproductive structure development GO:0048667 cell morphogenesis involved in neuron differentiation GO:0061458 reproductive system development GO:0061564 axon development GO:0097485 neuron projection guidance |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | LHX4 |
Name | LIM homeobox 4 |
Aliases | Gsh4; CPHD4; LIM homeobox protein 4; LIM/homeobox protein Lhx4 |
Chromosomal Location | 1q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LHX4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | LHX4 |
Name | LIM homeobox 4 |
Aliases | Gsh4; CPHD4; LIM homeobox protein 4; LIM/homeobox protein Lhx4 |
Chromosomal Location | 1q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LHX4 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | LHX4 |
Name | LIM homeobox 4 |
Aliases | Gsh4; CPHD4; LIM homeobox protein 4; LIM/homeobox protein Lhx4 |
Chromosomal Location | 1q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LHX4 in various data sets.
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Points in the above scatter plot represent the mutation difference of LHX4 in various data sets.
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Summary | |
---|---|
Symbol | LHX4 |
Name | LIM homeobox 4 |
Aliases | Gsh4; CPHD4; LIM homeobox protein 4; LIM/homeobox protein Lhx4 |
Chromosomal Location | 1q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LHX4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | LHX4 |
Name | LIM homeobox 4 |
Aliases | Gsh4; CPHD4; LIM homeobox protein 4; LIM/homeobox protein Lhx4 |
Chromosomal Location | 1q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LHX4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LHX4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LHX4 |
Name | LIM homeobox 4 |
Aliases | Gsh4; CPHD4; LIM homeobox protein 4; LIM/homeobox protein Lhx4 |
Chromosomal Location | 1q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LHX4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | LHX4 |
Name | LIM homeobox 4 |
Aliases | Gsh4; CPHD4; LIM homeobox protein 4; LIM/homeobox protein Lhx4 |
Chromosomal Location | 1q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LHX4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | LHX4 |
Name | LIM homeobox 4 |
Aliases | Gsh4; CPHD4; LIM homeobox protein 4; LIM/homeobox protein Lhx4 |
Chromosomal Location | 1q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LHX4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |