Summary | |
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Symbol | LILRA3 |
Name | leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 |
Aliases | LIR-4; HM43; ILT6; HM31; LIR4; CD85e; ILT-6; CD85 antigen-like family member E; immunoglobulin-like transcri ...... |
Chromosomal Location | 19q13.4 alternate reference locus |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF13895 Immunoglobulin domain |
Function |
Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes. |
Biological Process |
GO:0002250 adaptive immune response |
Molecular Function |
GO:0003823 antigen binding |
Cellular Component | - |
KEGG |
hsa04380 Osteoclast differentiation |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation |
Summary | |
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Symbol | LILRA3 |
Name | leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 |
Aliases | LIR-4; HM43; ILT6; HM31; LIR4; CD85e; ILT-6; CD85 antigen-like family member E; immunoglobulin-like transcri ...... |
Chromosomal Location | 19q13.4 alternate reference locus |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LILRA3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between LILRA3 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | LILRA3 |
Name | leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 |
Aliases | LIR-4; HM43; ILT6; HM31; LIR4; CD85e; ILT-6; CD85 antigen-like family member E; immunoglobulin-like transcri ...... |
Chromosomal Location | 19q13.4 alternate reference locus |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LILRA3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LILRA3 |
Name | leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 |
Aliases | LIR-4; HM43; ILT6; HM31; LIR4; CD85e; ILT-6; CD85 antigen-like family member E; immunoglobulin-like transcri ...... |
Chromosomal Location | 19q13.4 alternate reference locus |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LILRA3 in various data sets.
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Points in the above scatter plot represent the mutation difference of LILRA3 in various data sets.
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Summary | |
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Symbol | LILRA3 |
Name | leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 |
Aliases | LIR-4; HM43; ILT6; HM31; LIR4; CD85e; ILT-6; CD85 antigen-like family member E; immunoglobulin-like transcri ...... |
Chromosomal Location | 19q13.4 alternate reference locus |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LILRA3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | LILRA3 |
Name | leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 |
Aliases | LIR-4; HM43; ILT6; HM31; LIR4; CD85e; ILT-6; CD85 antigen-like family member E; immunoglobulin-like transcri ...... |
Chromosomal Location | 19q13.4 alternate reference locus |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LILRA3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LILRA3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LILRA3 |
Name | leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 |
Aliases | LIR-4; HM43; ILT6; HM31; LIR4; CD85e; ILT-6; CD85 antigen-like family member E; immunoglobulin-like transcri ...... |
Chromosomal Location | 19q13.4 alternate reference locus |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LILRA3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | LILRA3 |
Name | leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 |
Aliases | LIR-4; HM43; ILT6; HM31; LIR4; CD85e; ILT-6; CD85 antigen-like family member E; immunoglobulin-like transcri ...... |
Chromosomal Location | 19q13.4 alternate reference locus |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LILRA3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | LILRA3 |
Name | leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 |
Aliases | LIR-4; HM43; ILT6; HM31; LIR4; CD85e; ILT-6; CD85 antigen-like family member E; immunoglobulin-like transcri ...... |
Chromosomal Location | 19q13.4 alternate reference locus |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LILRA3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | LILRA3 |
Name | leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 |
Aliases | LIR-4; HM43; ILT6; HM31; LIR4; CD85e; ILT-6; CD85 antigen-like family member E; immunoglobulin-like transcri ...... |
Chromosomal Location | 19q13.4 alternate reference locus |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LILRA3 collected from DrugBank database. |
There is no record. |