Summary | |
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Symbol | LILRB1 |
Name | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 |
Aliases | LIR-1; ILT2; MIR-7; LIR1; CD85j; ILT-2; MIR7; CD85 antigen-like family member J; Ig-like transcript 2; leuko ...... |
Chromosomal Location | 19q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein ; SUBCELLULAR LOCATION: Isoform 5: Secreted |
Domain |
PF00047 Immunoglobulin domain PF13895 Immunoglobulin domain |
Function |
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. |
Biological Process |
GO:0001501 skeletal system development GO:0001818 negative regulation of cytokine production GO:0001820 serotonin secretion GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0001910 regulation of leukocyte mediated cytotoxicity GO:0001911 negative regulation of leukocyte mediated cytotoxicity GO:0001913 T cell mediated cytotoxicity GO:0001914 regulation of T cell mediated cytotoxicity GO:0001915 negative regulation of T cell mediated cytotoxicity GO:0002228 natural killer cell mediated immunity GO:0002230 positive regulation of defense response to virus by host GO:0002237 response to molecule of bacterial origin GO:0002250 adaptive immune response GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002286 T cell activation involved in immune response GO:0002290 gamma-delta T cell activation involved in immune response GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002309 T cell proliferation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002367 cytokine production involved in immune response GO:0002374 cytokine secretion involved in immune response GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002456 T cell mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002698 negative regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002701 negative regulation of production of molecular mediator of immune response GO:0002703 regulation of leukocyte mediated immunity GO:0002704 negative regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002707 negative regulation of lymphocyte mediated immunity GO:0002709 regulation of T cell mediated immunity GO:0002710 negative regulation of T cell mediated immunity GO:0002715 regulation of natural killer cell mediated immunity GO:0002716 negative regulation of natural killer cell mediated immunity GO:0002718 regulation of cytokine production involved in immune response GO:0002719 negative regulation of cytokine production involved in immune response GO:0002739 regulation of cytokine secretion involved in immune response GO:0002740 negative regulation of cytokine secretion involved in immune response GO:0002761 regulation of myeloid leukocyte differentiation GO:0002762 negative regulation of myeloid leukocyte differentiation GO:0002764 immune response-regulating signaling pathway GO:0002765 immune response-inhibiting signal transduction GO:0002767 immune response-inhibiting cell surface receptor signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0002774 Fc receptor mediated inhibitory signaling pathway GO:0002819 regulation of adaptive immune response GO:0002820 negative regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002831 regulation of response to biotic stimulus GO:0006816 calcium ion transport GO:0006837 serotonin transport GO:0006898 receptor-mediated endocytosis GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0009306 protein secretion GO:0009615 response to virus GO:0010721 negative regulation of cell development GO:0010959 regulation of metal ion transport GO:0014062 regulation of serotonin secretion GO:0014063 negative regulation of serotonin secretion GO:0015844 monoamine transport GO:0015850 organic hydroxy compound transport GO:0019835 cytolysis GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030099 myeloid cell differentiation GO:0030100 regulation of endocytosis GO:0030316 osteoclast differentiation GO:0031341 regulation of cell killing GO:0031342 negative regulation of cell killing GO:0031348 negative regulation of defense response GO:0031623 receptor internalization GO:0032479 regulation of type I interferon production GO:0032480 negative regulation of type I interferon production GO:0032496 response to lipopolysaccharide GO:0032606 type I interferon production GO:0032608 interferon-beta production GO:0032609 interferon-gamma production GO:0032613 interleukin-10 production GO:0032615 interleukin-12 production GO:0032640 tumor necrosis factor production GO:0032648 regulation of interferon-beta production GO:0032649 regulation of interferon-gamma production GO:0032653 regulation of interleukin-10 production GO:0032655 regulation of interleukin-12 production GO:0032680 regulation of tumor necrosis factor production GO:0032688 negative regulation of interferon-beta production GO:0032689 negative regulation of interferon-gamma production GO:0032693 negative regulation of interleukin-10 production GO:0032695 negative regulation of interleukin-12 production GO:0032720 negative regulation of tumor necrosis factor production GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032945 negative regulation of mononuclear cell proliferation GO:0035546 interferon-beta secretion GO:0035547 regulation of interferon-beta secretion GO:0035548 negative regulation of interferon-beta secretion GO:0036035 osteoclast development GO:0036037 CD8-positive, alpha-beta T cell activation GO:0038044 transforming growth factor-beta secretion GO:0042035 regulation of cytokine biosynthetic process GO:0042036 negative regulation of cytokine biosynthetic process GO:0042089 cytokine biosynthetic process GO:0042095 interferon-gamma biosynthetic process GO:0042098 T cell proliferation GO:0042107 cytokine metabolic process GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0042130 negative regulation of T cell proliferation GO:0042267 natural killer cell mediated cytotoxicity GO:0042268 regulation of cytolysis GO:0042269 regulation of natural killer cell mediated cytotoxicity GO:0042533 tumor necrosis factor biosynthetic process GO:0042534 regulation of tumor necrosis factor biosynthetic process GO:0042536 negative regulation of tumor necrosis factor biosynthetic process GO:0043112 receptor metabolic process GO:0043271 negative regulation of ion transport GO:0043900 regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0045072 regulation of interferon-gamma biosynthetic process GO:0045077 negative regulation of interferon-gamma biosynthetic process GO:0045088 regulation of innate immune response GO:0045637 regulation of myeloid cell differentiation GO:0045638 negative regulation of myeloid cell differentiation GO:0045670 regulation of osteoclast differentiation GO:0045671 negative regulation of osteoclast differentiation GO:0045785 positive regulation of cell adhesion GO:0045786 negative regulation of cell cycle GO:0045806 negative regulation of endocytosis GO:0045824 negative regulation of innate immune response GO:0045919 positive regulation of cytolysis GO:0045953 negative regulation of natural killer cell mediated cytotoxicity GO:0046629 gamma-delta T cell activation GO:0046631 alpha-beta T cell activation GO:0046634 regulation of alpha-beta T cell activation GO:0046636 negative regulation of alpha-beta T cell activation GO:0046643 regulation of gamma-delta T cell activation GO:0046645 positive regulation of gamma-delta T cell activation GO:0046651 lymphocyte proliferation GO:0050663 cytokine secretion GO:0050670 regulation of lymphocyte proliferation GO:0050672 negative regulation of lymphocyte proliferation GO:0050688 regulation of defense response to virus GO:0050691 regulation of defense response to virus by host GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050709 negative regulation of protein secretion GO:0050710 negative regulation of cytokine secretion GO:0050777 negative regulation of immune response GO:0050792 regulation of viral process GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050868 negative regulation of T cell activation GO:0050870 positive regulation of T cell activation GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051224 negative regulation of protein transport GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051607 defense response to virus GO:0051924 regulation of calcium ion transport GO:0051926 negative regulation of calcium ion transport GO:0060348 bone development GO:0060627 regulation of vesicle-mediated transport GO:0061515 myeloid cell development GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070664 negative regulation of leukocyte proliferation GO:0070838 divalent metal ion transport GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071396 cellular response to lipid GO:0071593 lymphocyte aggregation GO:0071706 tumor necrosis factor superfamily cytokine production GO:0071887 leukocyte apoptotic process GO:0072511 divalent inorganic cation transport GO:0072608 interleukin-10 secretion GO:0072610 interleukin-12 secretion GO:0072641 type I interferon secretion GO:0072643 interferon-gamma secretion GO:0097028 dendritic cell differentiation GO:0097048 dendritic cell apoptotic process GO:0098542 defense response to other organism GO:0098751 bone cell development GO:1902105 regulation of leukocyte differentiation GO:1902106 negative regulation of leukocyte differentiation GO:1903010 regulation of bone development GO:1903011 negative regulation of bone development GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903038 negative regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903531 negative regulation of secretion by cell GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production GO:1903706 regulation of hemopoiesis GO:1903707 negative regulation of hemopoiesis GO:1904950 negative regulation of establishment of protein localization GO:2000106 regulation of leukocyte apoptotic process GO:2000107 negative regulation of leukocyte apoptotic process GO:2000668 regulation of dendritic cell apoptotic process GO:2000669 negative regulation of dendritic cell apoptotic process GO:2001179 regulation of interleukin-10 secretion GO:2001180 negative regulation of interleukin-10 secretion GO:2001182 regulation of interleukin-12 secretion GO:2001183 negative regulation of interleukin-12 secretion GO:2001185 regulation of CD8-positive, alpha-beta T cell activation GO:2001186 negative regulation of CD8-positive, alpha-beta T cell activation GO:2001188 regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:2001189 negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:2001191 regulation of gamma-delta T cell activation involved in immune response GO:2001193 positive regulation of gamma-delta T cell activation involved in immune response GO:2001198 regulation of dendritic cell differentiation GO:2001199 negative regulation of dendritic cell differentiation GO:2001201 regulation of transforming growth factor-beta secretion GO:2001202 negative regulation of transforming growth factor-beta secretion GO:2001204 regulation of osteoclast development GO:2001205 negative regulation of osteoclast development |
Molecular Function |
GO:0008157 protein phosphatase 1 binding GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding GO:0030107 HLA-A specific inhibitory MHC class I receptor activity GO:0030109 HLA-B specific inhibitory MHC class I receptor activity GO:0032393 MHC class I receptor activity GO:0032396 inhibitory MHC class I receptor activity GO:0042169 SH2 domain binding GO:0042287 MHC protein binding GO:0042288 MHC class I protein binding |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0098552 side of membrane |
KEGG |
hsa04380 Osteoclast differentiation |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Summary | |
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Symbol | LILRB1 |
Name | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 |
Aliases | LIR-1; ILT2; MIR-7; LIR1; CD85j; ILT-2; MIR7; CD85 antigen-like family member J; Ig-like transcript 2; leuko ...... |
Chromosomal Location | 19q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LILRB1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between LILRB1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | LILRB1 |
Name | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 |
Aliases | LIR-1; ILT2; MIR-7; LIR1; CD85j; ILT-2; MIR7; CD85 antigen-like family member J; Ig-like transcript 2; leuko ...... |
Chromosomal Location | 19q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LILRB1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LILRB1 |
Name | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 |
Aliases | LIR-1; ILT2; MIR-7; LIR1; CD85j; ILT-2; MIR7; CD85 antigen-like family member J; Ig-like transcript 2; leuko ...... |
Chromosomal Location | 19q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LILRB1 in various data sets.
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Points in the above scatter plot represent the mutation difference of LILRB1 in various data sets.
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Summary | |
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Symbol | LILRB1 |
Name | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 |
Aliases | LIR-1; ILT2; MIR-7; LIR1; CD85j; ILT-2; MIR7; CD85 antigen-like family member J; Ig-like transcript 2; leuko ...... |
Chromosomal Location | 19q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LILRB1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | LILRB1 |
Name | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 |
Aliases | LIR-1; ILT2; MIR-7; LIR1; CD85j; ILT-2; MIR7; CD85 antigen-like family member J; Ig-like transcript 2; leuko ...... |
Chromosomal Location | 19q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LILRB1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LILRB1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LILRB1 |
Name | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 |
Aliases | LIR-1; ILT2; MIR-7; LIR1; CD85j; ILT-2; MIR7; CD85 antigen-like family member J; Ig-like transcript 2; leuko ...... |
Chromosomal Location | 19q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LILRB1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | LILRB1 |
Name | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 |
Aliases | LIR-1; ILT2; MIR-7; LIR1; CD85j; ILT-2; MIR7; CD85 antigen-like family member J; Ig-like transcript 2; leuko ...... |
Chromosomal Location | 19q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LILRB1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | LILRB1 |
Name | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 |
Aliases | LIR-1; ILT2; MIR-7; LIR1; CD85j; ILT-2; MIR7; CD85 antigen-like family member J; Ig-like transcript 2; leuko ...... |
Chromosomal Location | 19q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LILRB1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | LILRB1 |
Name | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 |
Aliases | LIR-1; ILT2; MIR-7; LIR1; CD85j; ILT-2; MIR7; CD85 antigen-like family member J; Ig-like transcript 2; leuko ...... |
Chromosomal Location | 19q13.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LILRB1 collected from DrugBank database. |
There is no record. |