Summary | |
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Symbol | LIMA1 |
Name | LIM domain and actin binding 1 |
Aliases | EPLIN; epithelial protein lost in neoplasm beta; SREBP3; 1110021C24Rik; sterol regulatory element binding pr ...... |
Chromosomal Location | 12q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=This cytoskeletal protein co-localizes with actin stress fibers and focal adhesion plaques. |
Domain |
PF00412 LIM domain |
Function |
Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments. |
Biological Process |
GO:0007015 actin filament organization GO:0008064 regulation of actin polymerization or depolymerization GO:0008154 actin polymerization or depolymerization GO:0010639 negative regulation of organelle organization GO:0030042 actin filament depolymerization GO:0030832 regulation of actin filament length GO:0030834 regulation of actin filament depolymerization GO:0030835 negative regulation of actin filament depolymerization GO:0031529 ruffle organization GO:0032535 regulation of cellular component size GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0032984 macromolecular complex disassembly GO:0043241 protein complex disassembly GO:0043242 negative regulation of protein complex disassembly GO:0043244 regulation of protein complex disassembly GO:0043624 cellular protein complex disassembly GO:0051017 actin filament bundle assembly GO:0051261 protein depolymerization GO:0051493 regulation of cytoskeleton organization GO:0051494 negative regulation of cytoskeleton organization GO:0061572 actin filament bundle organization GO:0090066 regulation of anatomical structure size GO:1901879 regulation of protein depolymerization GO:1901880 negative regulation of protein depolymerization |
Molecular Function |
GO:0003779 actin binding GO:0003785 actin monomer binding GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0051015 actin filament binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0001725 stress fiber GO:0005903 brush border GO:0005913 cell-cell adherens junction GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0015629 actin cytoskeleton GO:0030055 cell-substrate junction GO:0032153 cell division site GO:0032154 cleavage furrow GO:0032155 cell division site part GO:0032432 actin filament bundle GO:0042641 actomyosin GO:0097517 contractile actin filament bundle GO:0097610 cell surface furrow GO:0098862 cluster of actin-based cell projections |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | LIMA1 |
Name | LIM domain and actin binding 1 |
Aliases | EPLIN; epithelial protein lost in neoplasm beta; SREBP3; 1110021C24Rik; sterol regulatory element binding pr ...... |
Chromosomal Location | 12q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LIMA1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | LIMA1 |
Name | LIM domain and actin binding 1 |
Aliases | EPLIN; epithelial protein lost in neoplasm beta; SREBP3; 1110021C24Rik; sterol regulatory element binding pr ...... |
Chromosomal Location | 12q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LIMA1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | LIMA1 |
Name | LIM domain and actin binding 1 |
Aliases | EPLIN; epithelial protein lost in neoplasm beta; SREBP3; 1110021C24Rik; sterol regulatory element binding pr ...... |
Chromosomal Location | 12q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LIMA1 in various data sets.
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Points in the above scatter plot represent the mutation difference of LIMA1 in various data sets.
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Summary | |
---|---|
Symbol | LIMA1 |
Name | LIM domain and actin binding 1 |
Aliases | EPLIN; epithelial protein lost in neoplasm beta; SREBP3; 1110021C24Rik; sterol regulatory element binding pr ...... |
Chromosomal Location | 12q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LIMA1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | LIMA1 |
Name | LIM domain and actin binding 1 |
Aliases | EPLIN; epithelial protein lost in neoplasm beta; SREBP3; 1110021C24Rik; sterol regulatory element binding pr ...... |
Chromosomal Location | 12q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LIMA1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LIMA1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | LIMA1 |
Name | LIM domain and actin binding 1 |
Aliases | EPLIN; epithelial protein lost in neoplasm beta; SREBP3; 1110021C24Rik; sterol regulatory element binding pr ...... |
Chromosomal Location | 12q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LIMA1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | LIMA1 |
Name | LIM domain and actin binding 1 |
Aliases | EPLIN; epithelial protein lost in neoplasm beta; SREBP3; 1110021C24Rik; sterol regulatory element binding pr ...... |
Chromosomal Location | 12q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LIMA1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | LIMA1 |
Name | LIM domain and actin binding 1 |
Aliases | EPLIN; epithelial protein lost in neoplasm beta; SREBP3; 1110021C24Rik; sterol regulatory element binding pr ...... |
Chromosomal Location | 12q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LIMA1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | LIMA1 |
Name | LIM domain and actin binding 1 |
Aliases | EPLIN; epithelial protein lost in neoplasm beta; SREBP3; 1110021C24Rik; sterol regulatory element binding pr ...... |
Chromosomal Location | 12q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LIMA1 collected from DrugBank database. |
There is no record. |