Summary | |
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Symbol | LIN9 |
Name | lin-9 DREAM MuvB core complex component |
Aliases | TGS; TUDOR gene similar; rb related pathway actor; lin-9 homolog (C. elegans); BARA; BARPsv; Lin-9; TGS2; TU ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus, nucleoplasm Note=Found in perinucleolar structures. Associated with chromatin. |
Domain |
PF06584 DIRP |
Function |
Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. |
Biological Process |
GO:0071897 DNA biosynthetic process |
Molecular Function | - |
Cellular Component |
GO:0017053 transcriptional repressor complex |
KEGG | - |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-1538133: G0 and Early G1 R-HSA-69275: G2/M Transition R-HSA-453279: Mitotic G1-G1/S phases R-HSA-453274: Mitotic G2-G2/M phases R-HSA-156711: Polo-like kinase mediated events |
Summary | |
---|---|
Symbol | LIN9 |
Name | lin-9 DREAM MuvB core complex component |
Aliases | TGS; TUDOR gene similar; rb related pathway actor; lin-9 homolog (C. elegans); BARA; BARPsv; Lin-9; TGS2; TU ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LIN9 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | LIN9 |
Name | lin-9 DREAM MuvB core complex component |
Aliases | TGS; TUDOR gene similar; rb related pathway actor; lin-9 homolog (C. elegans); BARA; BARPsv; Lin-9; TGS2; TU ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LIN9 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LIN9 |
Name | lin-9 DREAM MuvB core complex component |
Aliases | TGS; TUDOR gene similar; rb related pathway actor; lin-9 homolog (C. elegans); BARA; BARPsv; Lin-9; TGS2; TU ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LIN9 in various data sets.
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Points in the above scatter plot represent the mutation difference of LIN9 in various data sets.
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Summary | |
---|---|
Symbol | LIN9 |
Name | lin-9 DREAM MuvB core complex component |
Aliases | TGS; TUDOR gene similar; rb related pathway actor; lin-9 homolog (C. elegans); BARA; BARPsv; Lin-9; TGS2; TU ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LIN9. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | LIN9 |
Name | lin-9 DREAM MuvB core complex component |
Aliases | TGS; TUDOR gene similar; rb related pathway actor; lin-9 homolog (C. elegans); BARA; BARPsv; Lin-9; TGS2; TU ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LIN9. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LIN9. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | LIN9 |
Name | lin-9 DREAM MuvB core complex component |
Aliases | TGS; TUDOR gene similar; rb related pathway actor; lin-9 homolog (C. elegans); BARA; BARPsv; Lin-9; TGS2; TU ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LIN9. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | LIN9 |
Name | lin-9 DREAM MuvB core complex component |
Aliases | TGS; TUDOR gene similar; rb related pathway actor; lin-9 homolog (C. elegans); BARA; BARPsv; Lin-9; TGS2; TU ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LIN9 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | LIN9 |
Name | lin-9 DREAM MuvB core complex component |
Aliases | TGS; TUDOR gene similar; rb related pathway actor; lin-9 homolog (C. elegans); BARA; BARPsv; Lin-9; TGS2; TU ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LIN9 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | LIN9 |
Name | lin-9 DREAM MuvB core complex component |
Aliases | TGS; TUDOR gene similar; rb related pathway actor; lin-9 homolog (C. elegans); BARA; BARPsv; Lin-9; TGS2; TU ...... |
Chromosomal Location | 1q42 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LIN9 collected from DrugBank database. |
There is no record. |