Summary | |
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Symbol | LIPM |
Name | lipase, family member M |
Aliases | bA304I5.1; LIPL3; lipase-like, ab-hydrolase domain containing 3; lipase M; lipase-like abhydrolase domain-co ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF00561 alpha/beta hydrolase fold |
Function |
Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers. |
Biological Process |
GO:0007586 digestion GO:0016042 lipid catabolic process GO:0044241 lipid digestion |
Molecular Function |
GO:0004465 lipoprotein lipase activity GO:0004806 triglyceride lipase activity GO:0016298 lipase activity GO:0052689 carboxylic ester hydrolase activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-192456: Digestion of dietary lipid R-HSA-73923: Lipid digestion, mobilization, and transport R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins |
Summary | |
---|---|
Symbol | LIPM |
Name | lipase, family member M |
Aliases | bA304I5.1; LIPL3; lipase-like, ab-hydrolase domain containing 3; lipase M; lipase-like abhydrolase domain-co ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LIPM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | LIPM |
Name | lipase, family member M |
Aliases | bA304I5.1; LIPL3; lipase-like, ab-hydrolase domain containing 3; lipase M; lipase-like abhydrolase domain-co ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LIPM in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | LIPM |
Name | lipase, family member M |
Aliases | bA304I5.1; LIPL3; lipase-like, ab-hydrolase domain containing 3; lipase M; lipase-like abhydrolase domain-co ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LIPM in various data sets.
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Points in the above scatter plot represent the mutation difference of LIPM in various data sets.
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Summary | |
---|---|
Symbol | LIPM |
Name | lipase, family member M |
Aliases | bA304I5.1; LIPL3; lipase-like, ab-hydrolase domain containing 3; lipase M; lipase-like abhydrolase domain-co ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LIPM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | LIPM |
Name | lipase, family member M |
Aliases | bA304I5.1; LIPL3; lipase-like, ab-hydrolase domain containing 3; lipase M; lipase-like abhydrolase domain-co ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LIPM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LIPM. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | LIPM |
Name | lipase, family member M |
Aliases | bA304I5.1; LIPL3; lipase-like, ab-hydrolase domain containing 3; lipase M; lipase-like abhydrolase domain-co ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LIPM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | LIPM |
Name | lipase, family member M |
Aliases | bA304I5.1; LIPL3; lipase-like, ab-hydrolase domain containing 3; lipase M; lipase-like abhydrolase domain-co ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LIPM expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | LIPM |
Name | lipase, family member M |
Aliases | bA304I5.1; LIPL3; lipase-like, ab-hydrolase domain containing 3; lipase M; lipase-like abhydrolase domain-co ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LIPM and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | LIPM |
Name | lipase, family member M |
Aliases | bA304I5.1; LIPL3; lipase-like, ab-hydrolase domain containing 3; lipase M; lipase-like abhydrolase domain-co ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LIPM collected from DrugBank database. |
There is no record. |