Summary | |
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Symbol | LMTK2 |
Name | lemur tyrosine kinase 2 |
Aliases | KIAA1079; KPI2; KPI-2; cprk; LMR2; BREK; AATYK2; PPP1R100; protein phosphatase 1, regulatory subunit 100; CD ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Multi-pass membrane protein |
Domain |
PF07714 Protein tyrosine kinase |
Function |
Phosphorylates PPP1C, phosphorylase b and CFTR. |
Biological Process |
GO:0000041 transition metal ion transport GO:0001881 receptor recycling GO:0006826 iron ion transport GO:0007034 vacuolar transport GO:0015682 ferric iron transport GO:0016197 endosomal transport GO:0016482 cytosolic transport GO:0018105 peptidyl-serine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0018209 peptidyl-serine modification GO:0018210 peptidyl-threonine modification GO:0032456 endocytic recycling GO:0033572 transferrin transport GO:0043112 receptor metabolic process GO:0045022 early endosome to late endosome transport GO:0046777 protein autophosphorylation GO:0072512 trivalent inorganic cation transport GO:0098927 vesicle-mediated transport between endosomal compartments |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004857 enzyme inhibitor activity GO:0004864 protein phosphatase inhibitor activity GO:0017022 myosin binding GO:0019208 phosphatase regulator activity GO:0019212 phosphatase inhibitor activity GO:0019888 protein phosphatase regulator activity GO:0070853 myosin VI binding |
Cellular Component |
GO:0005769 early endosome GO:0055037 recycling endosome |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | LMTK2 |
Name | lemur tyrosine kinase 2 |
Aliases | KIAA1079; KPI2; KPI-2; cprk; LMR2; BREK; AATYK2; PPP1R100; protein phosphatase 1, regulatory subunit 100; CD ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LMTK2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | LMTK2 |
Name | lemur tyrosine kinase 2 |
Aliases | KIAA1079; KPI2; KPI-2; cprk; LMR2; BREK; AATYK2; PPP1R100; protein phosphatase 1, regulatory subunit 100; CD ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LMTK2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LMTK2 |
Name | lemur tyrosine kinase 2 |
Aliases | KIAA1079; KPI2; KPI-2; cprk; LMR2; BREK; AATYK2; PPP1R100; protein phosphatase 1, regulatory subunit 100; CD ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LMTK2 in various data sets.
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Points in the above scatter plot represent the mutation difference of LMTK2 in various data sets.
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Summary | |
---|---|
Symbol | LMTK2 |
Name | lemur tyrosine kinase 2 |
Aliases | KIAA1079; KPI2; KPI-2; cprk; LMR2; BREK; AATYK2; PPP1R100; protein phosphatase 1, regulatory subunit 100; CD ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LMTK2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | LMTK2 |
Name | lemur tyrosine kinase 2 |
Aliases | KIAA1079; KPI2; KPI-2; cprk; LMR2; BREK; AATYK2; PPP1R100; protein phosphatase 1, regulatory subunit 100; CD ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LMTK2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LMTK2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LMTK2 |
Name | lemur tyrosine kinase 2 |
Aliases | KIAA1079; KPI2; KPI-2; cprk; LMR2; BREK; AATYK2; PPP1R100; protein phosphatase 1, regulatory subunit 100; CD ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LMTK2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | LMTK2 |
Name | lemur tyrosine kinase 2 |
Aliases | KIAA1079; KPI2; KPI-2; cprk; LMR2; BREK; AATYK2; PPP1R100; protein phosphatase 1, regulatory subunit 100; CD ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LMTK2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | LMTK2 |
Name | lemur tyrosine kinase 2 |
Aliases | KIAA1079; KPI2; KPI-2; cprk; LMR2; BREK; AATYK2; PPP1R100; protein phosphatase 1, regulatory subunit 100; CD ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LMTK2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | LMTK2 |
Name | lemur tyrosine kinase 2 |
Aliases | KIAA1079; KPI2; KPI-2; cprk; LMR2; BREK; AATYK2; PPP1R100; protein phosphatase 1, regulatory subunit 100; CD ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LMTK2 collected from DrugBank database. |
There is no record. |