Summary | |
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Symbol | LPAR1 |
Name | lysophosphatidic acid receptor 1 |
Aliases | rec.1.3; vzg-1; Gpcr26; Mrec1.3; LPA1; endothelial differentiation, lysophosphatidic acid G-protein-coupled ...... |
Chromosomal Location | 9q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell surface Cell membrane Multi-pass membrane protein Endosome Note=Prior to LPA treatment found predominantly at the cell surface. Internalized after LPA treatment. Colocalizes with RALA in endocytic vesicles after LPA treatment. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity). |
Biological Process |
GO:0000187 activation of MAPK activity GO:0006140 regulation of nucleotide metabolic process GO:0006164 purine nucleotide biosynthetic process GO:0006171 cAMP biosynthetic process GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007015 actin filament organization GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007202 activation of phospholipase C activity GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007265 Ras protein signal transduction GO:0007266 Rho protein signal transduction GO:0007272 ensheathment of neurons GO:0008360 regulation of cell shape GO:0008366 axon ensheathment GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009187 cyclic nucleotide metabolic process GO:0009190 cyclic nucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0010001 glial cell differentiation GO:0010517 regulation of phospholipase activity GO:0010518 positive regulation of phospholipase activity GO:0010720 positive regulation of cell development GO:0010721 negative regulation of cell development GO:0010863 positive regulation of phospholipase C activity GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0014003 oligodendrocyte development GO:0014812 muscle cell migration GO:0014909 smooth muscle cell migration GO:0014910 regulation of smooth muscle cell migration GO:0014911 positive regulation of smooth muscle cell migration GO:0016358 dendrite development GO:0021537 telencephalon development GO:0021545 cranial nerve development GO:0021549 cerebellum development GO:0021554 optic nerve development GO:0021675 nerve development GO:0021782 glial cell development GO:0022037 metencephalon development GO:0022038 corpus callosum development GO:0022604 regulation of cell morphogenesis GO:0030031 cell projection assembly GO:0030038 contractile actin filament bundle assembly GO:0030335 positive regulation of cell migration GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030800 negative regulation of cyclic nucleotide metabolic process GO:0030802 regulation of cyclic nucleotide biosynthetic process GO:0030803 negative regulation of cyclic nucleotide biosynthetic process GO:0030808 regulation of nucleotide biosynthetic process GO:0030809 negative regulation of nucleotide biosynthetic process GO:0030814 regulation of cAMP metabolic process GO:0030815 negative regulation of cAMP metabolic process GO:0030817 regulation of cAMP biosynthetic process GO:0030818 negative regulation of cAMP biosynthetic process GO:0030900 forebrain development GO:0030902 hindbrain development GO:0031032 actomyosin structure organization GO:0031345 negative regulation of cell projection organization GO:0031346 positive regulation of cell projection organization GO:0032060 bleb assembly GO:0032103 positive regulation of response to external stimulus GO:0032147 activation of protein kinase activity GO:0032231 regulation of actin filament bundle assembly GO:0032233 positive regulation of actin filament bundle assembly GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0033674 positive regulation of kinase activity GO:0035023 regulation of Rho protein signal transduction GO:0035025 positive regulation of Rho protein signal transduction GO:0040017 positive regulation of locomotion GO:0042063 gliogenesis GO:0042552 myelination GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043149 stress fiber assembly GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0044089 positive regulation of cellular component biogenesis GO:0045665 negative regulation of neuron differentiation GO:0045666 positive regulation of neuron differentiation GO:0045860 positive regulation of protein kinase activity GO:0045980 negative regulation of nucleotide metabolic process GO:0046058 cAMP metabolic process GO:0046390 ribose phosphate biosynthetic process GO:0046578 regulation of Ras protein signal transduction GO:0046579 positive regulation of Ras protein signal transduction GO:0046683 response to organophosphorus GO:0048709 oligodendrocyte differentiation GO:0050768 negative regulation of neurogenesis GO:0050769 positive regulation of neurogenesis GO:0050773 regulation of dendrite development GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051017 actin filament bundle assembly GO:0051056 regulation of small GTPase mediated signal transduction GO:0051057 positive regulation of small GTPase mediated signal transduction GO:0051272 positive regulation of cellular component movement GO:0051480 regulation of cytosolic calcium ion concentration GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051492 regulation of stress fiber assembly GO:0051493 regulation of cytoskeleton organization GO:0051495 positive regulation of cytoskeleton organization GO:0051496 positive regulation of stress fiber assembly GO:0051961 negative regulation of nervous system development GO:0051962 positive regulation of nervous system development GO:0052652 cyclic purine nucleotide metabolic process GO:0055074 calcium ion homeostasis GO:0060191 regulation of lipase activity GO:0060193 positive regulation of lipase activity GO:0060326 cell chemotaxis GO:0060996 dendritic spine development GO:0060998 regulation of dendritic spine development GO:0060999 positive regulation of dendritic spine development GO:0061572 actin filament bundle organization GO:0070482 response to oxygen levels GO:0071396 cellular response to lipid GO:0071453 cellular response to oxygen levels GO:0071670 smooth muscle cell chemotaxis GO:0071671 regulation of smooth muscle cell chemotaxis GO:0071673 positive regulation of smooth muscle cell chemotaxis GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072522 purine-containing compound biosynthetic process GO:1900006 positive regulation of dendrite development GO:1900274 regulation of phospholipase C activity GO:1900371 regulation of purine nucleotide biosynthetic process GO:1900372 negative regulation of purine nucleotide biosynthetic process GO:1900542 regulation of purine nucleotide metabolic process GO:1900543 negative regulation of purine nucleotide metabolic process GO:1901293 nucleoside phosphate biosynthetic process GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate GO:1904566 cellular response to 1-oleoyl-sn-glycerol 3-phosphate GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0001965 G-protein alpha-subunit binding GO:0005543 phospholipid binding GO:0030165 PDZ domain binding GO:0035727 lysophosphatidic acid binding GO:0045125 bioactive lipid receptor activity GO:0070915 lysophosphatidic acid receptor activity |
Cellular Component |
GO:0030139 endocytic vesicle GO:0030425 dendrite GO:0043025 neuronal cell body GO:0043197 dendritic spine GO:0043198 dendritic shaft GO:0044297 cell body GO:0044309 neuron spine GO:0098794 postsynapse |
KEGG |
hsa04015 Rap1 signaling pathway hsa04080 Neuroactive ligand-receptor interaction hsa04151 PI3K-Akt signaling pathway hsa04540 Gap junction |
Reactome |
R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-419408: Lysosphingolipid and LPA receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | LPAR1 |
Name | lysophosphatidic acid receptor 1 |
Aliases | rec.1.3; vzg-1; Gpcr26; Mrec1.3; LPA1; endothelial differentiation, lysophosphatidic acid G-protein-coupled ...... |
Chromosomal Location | 9q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LPAR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | LPAR1 |
Name | lysophosphatidic acid receptor 1 |
Aliases | rec.1.3; vzg-1; Gpcr26; Mrec1.3; LPA1; endothelial differentiation, lysophosphatidic acid G-protein-coupled ...... |
Chromosomal Location | 9q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LPAR1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LPAR1 |
Name | lysophosphatidic acid receptor 1 |
Aliases | rec.1.3; vzg-1; Gpcr26; Mrec1.3; LPA1; endothelial differentiation, lysophosphatidic acid G-protein-coupled ...... |
Chromosomal Location | 9q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LPAR1 in various data sets.
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Points in the above scatter plot represent the mutation difference of LPAR1 in various data sets.
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Summary | |
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Symbol | LPAR1 |
Name | lysophosphatidic acid receptor 1 |
Aliases | rec.1.3; vzg-1; Gpcr26; Mrec1.3; LPA1; endothelial differentiation, lysophosphatidic acid G-protein-coupled ...... |
Chromosomal Location | 9q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LPAR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | LPAR1 |
Name | lysophosphatidic acid receptor 1 |
Aliases | rec.1.3; vzg-1; Gpcr26; Mrec1.3; LPA1; endothelial differentiation, lysophosphatidic acid G-protein-coupled ...... |
Chromosomal Location | 9q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LPAR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LPAR1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | LPAR1 |
Name | lysophosphatidic acid receptor 1 |
Aliases | rec.1.3; vzg-1; Gpcr26; Mrec1.3; LPA1; endothelial differentiation, lysophosphatidic acid G-protein-coupled ...... |
Chromosomal Location | 9q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LPAR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | LPAR1 |
Name | lysophosphatidic acid receptor 1 |
Aliases | rec.1.3; vzg-1; Gpcr26; Mrec1.3; LPA1; endothelial differentiation, lysophosphatidic acid G-protein-coupled ...... |
Chromosomal Location | 9q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LPAR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | LPAR1 |
Name | lysophosphatidic acid receptor 1 |
Aliases | rec.1.3; vzg-1; Gpcr26; Mrec1.3; LPA1; endothelial differentiation, lysophosphatidic acid G-protein-coupled ...... |
Chromosomal Location | 9q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LPAR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | LPAR1 |
Name | lysophosphatidic acid receptor 1 |
Aliases | rec.1.3; vzg-1; Gpcr26; Mrec1.3; LPA1; endothelial differentiation, lysophosphatidic acid G-protein-coupled ...... |
Chromosomal Location | 9q |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LPAR1 collected from DrugBank database. |
There is no record. |