Summary | |
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Symbol | LPAR5 |
Name | lysophosphatidic acid receptor 5 |
Aliases | KPG_010; LPA5; GPR93; GPR92; G protein-coupled receptor 92; G-protein coupled receptor 92; G-protein coupled ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. |
Biological Process | - |
Molecular Function | - |
Cellular Component | - |
KEGG |
hsa04015 Rap1 signaling pathway hsa04151 PI3K-Akt signaling pathway |
Reactome |
R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-419408: Lysosphingolipid and LPA receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
---|---|
Symbol | LPAR5 |
Name | lysophosphatidic acid receptor 5 |
Aliases | KPG_010; LPA5; GPR93; GPR92; G protein-coupled receptor 92; G-protein coupled receptor 92; G-protein coupled ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LPAR5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between LPAR5 and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | LPAR5 |
Name | lysophosphatidic acid receptor 5 |
Aliases | KPG_010; LPA5; GPR93; GPR92; G protein-coupled receptor 92; G-protein coupled receptor 92; G-protein coupled ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LPAR5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LPAR5 |
Name | lysophosphatidic acid receptor 5 |
Aliases | KPG_010; LPA5; GPR93; GPR92; G protein-coupled receptor 92; G-protein coupled receptor 92; G-protein coupled ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LPAR5 in various data sets.
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Points in the above scatter plot represent the mutation difference of LPAR5 in various data sets.
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Summary | |
---|---|
Symbol | LPAR5 |
Name | lysophosphatidic acid receptor 5 |
Aliases | KPG_010; LPA5; GPR93; GPR92; G protein-coupled receptor 92; G-protein coupled receptor 92; G-protein coupled ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LPAR5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | LPAR5 |
Name | lysophosphatidic acid receptor 5 |
Aliases | KPG_010; LPA5; GPR93; GPR92; G protein-coupled receptor 92; G-protein coupled receptor 92; G-protein coupled ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LPAR5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LPAR5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | LPAR5 |
Name | lysophosphatidic acid receptor 5 |
Aliases | KPG_010; LPA5; GPR93; GPR92; G protein-coupled receptor 92; G-protein coupled receptor 92; G-protein coupled ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LPAR5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | LPAR5 |
Name | lysophosphatidic acid receptor 5 |
Aliases | KPG_010; LPA5; GPR93; GPR92; G protein-coupled receptor 92; G-protein coupled receptor 92; G-protein coupled ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LPAR5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | LPAR5 |
Name | lysophosphatidic acid receptor 5 |
Aliases | KPG_010; LPA5; GPR93; GPR92; G protein-coupled receptor 92; G-protein coupled receptor 92; G-protein coupled ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LPAR5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | LPAR5 |
Name | lysophosphatidic acid receptor 5 |
Aliases | KPG_010; LPA5; GPR93; GPR92; G protein-coupled receptor 92; G-protein coupled receptor 92; G-protein coupled ...... |
Chromosomal Location | 12p13.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LPAR5 collected from DrugBank database. |
There is no record. |