Summary | |
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Symbol | LRGUK |
Name | leucine-rich repeats and guanylate kinase domain containing |
Aliases | FLJ32786; CFAP246; Leucine-rich repeat and guanylate kinase domain-containing protein |
Chromosomal Location | 7q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasmic vesicle, secretory vesicle, acrosome Cytoplasm, cytoskeleton Cytoplasm, cytoskeleton, cilium basal body Note=Localizes to the acrosome and acroplaxome in round spermatids. Localizes to the manchette during spermiogenesis. Also found in the basal body of elongating spermatids, and in primary cilia of somatic cells. |
Domain |
PF00625 Guanylate kinase |
Function |
Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. |
Biological Process |
GO:0000226 microtubule cytoskeleton organization GO:0001578 microtubule bundle formation GO:0007283 spermatogenesis GO:0010927 cellular component assembly involved in morphogenesis GO:0030031 cell projection assembly GO:0035082 axoneme assembly GO:0042384 cilium assembly GO:0044782 cilium organization GO:0048232 male gamete generation GO:0060271 cilium morphogenesis |
Molecular Function | - |
Cellular Component |
GO:0001669 acrosomal vesicle GO:0002177 manchette GO:0030141 secretory granule GO:0097223 sperm part GO:0099503 secretory vesicle |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | LRGUK |
Name | leucine-rich repeats and guanylate kinase domain containing |
Aliases | FLJ32786; CFAP246; Leucine-rich repeat and guanylate kinase domain-containing protein |
Chromosomal Location | 7q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LRGUK and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | LRGUK |
Name | leucine-rich repeats and guanylate kinase domain containing |
Aliases | FLJ32786; CFAP246; Leucine-rich repeat and guanylate kinase domain-containing protein |
Chromosomal Location | 7q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LRGUK in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LRGUK |
Name | leucine-rich repeats and guanylate kinase domain containing |
Aliases | FLJ32786; CFAP246; Leucine-rich repeat and guanylate kinase domain-containing protein |
Chromosomal Location | 7q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LRGUK in various data sets.
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Points in the above scatter plot represent the mutation difference of LRGUK in various data sets.
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Summary | |
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Symbol | LRGUK |
Name | leucine-rich repeats and guanylate kinase domain containing |
Aliases | FLJ32786; CFAP246; Leucine-rich repeat and guanylate kinase domain-containing protein |
Chromosomal Location | 7q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LRGUK. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | LRGUK |
Name | leucine-rich repeats and guanylate kinase domain containing |
Aliases | FLJ32786; CFAP246; Leucine-rich repeat and guanylate kinase domain-containing protein |
Chromosomal Location | 7q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LRGUK. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LRGUK. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LRGUK |
Name | leucine-rich repeats and guanylate kinase domain containing |
Aliases | FLJ32786; CFAP246; Leucine-rich repeat and guanylate kinase domain-containing protein |
Chromosomal Location | 7q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LRGUK. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | LRGUK |
Name | leucine-rich repeats and guanylate kinase domain containing |
Aliases | FLJ32786; CFAP246; Leucine-rich repeat and guanylate kinase domain-containing protein |
Chromosomal Location | 7q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LRGUK expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | LRGUK |
Name | leucine-rich repeats and guanylate kinase domain containing |
Aliases | FLJ32786; CFAP246; Leucine-rich repeat and guanylate kinase domain-containing protein |
Chromosomal Location | 7q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LRGUK and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | LRGUK |
Name | leucine-rich repeats and guanylate kinase domain containing |
Aliases | FLJ32786; CFAP246; Leucine-rich repeat and guanylate kinase domain-containing protein |
Chromosomal Location | 7q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LRGUK collected from DrugBank database. |
There is no record. |