Summary | |
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Symbol | LRIG3 |
Name | leucine-rich repeats and immunoglobulin-like domains 3 |
Aliases | FLJ90440; KIAA3016; LIG-3; Leucine-rich repeats and immunoglobulin-like domains protein 3 |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Cytoplasmic vesicle membrane Single-pass type I membrane protein Note=Detected in cytoplasmic vesicles when coexpressed with ERBB4. |
Domain |
PF07679 Immunoglobulin I-set domain PF13855 Leucine rich repeat |
Function |
May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). |
Biological Process |
GO:0007423 sensory organ development GO:0032474 otolith morphogenesis GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0043583 ear development GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048839 inner ear development GO:0048840 otolith development GO:0090596 sensory organ morphogenesis |
Molecular Function | - |
Cellular Component |
GO:0030659 cytoplasmic vesicle membrane |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | LRIG3 |
Name | leucine-rich repeats and immunoglobulin-like domains 3 |
Aliases | FLJ90440; KIAA3016; LIG-3; Leucine-rich repeats and immunoglobulin-like domains protein 3 |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LRIG3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | LRIG3 |
Name | leucine-rich repeats and immunoglobulin-like domains 3 |
Aliases | FLJ90440; KIAA3016; LIG-3; Leucine-rich repeats and immunoglobulin-like domains protein 3 |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LRIG3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LRIG3 |
Name | leucine-rich repeats and immunoglobulin-like domains 3 |
Aliases | FLJ90440; KIAA3016; LIG-3; Leucine-rich repeats and immunoglobulin-like domains protein 3 |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LRIG3 in various data sets.
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Points in the above scatter plot represent the mutation difference of LRIG3 in various data sets.
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Summary | |
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Symbol | LRIG3 |
Name | leucine-rich repeats and immunoglobulin-like domains 3 |
Aliases | FLJ90440; KIAA3016; LIG-3; Leucine-rich repeats and immunoglobulin-like domains protein 3 |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LRIG3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | LRIG3 |
Name | leucine-rich repeats and immunoglobulin-like domains 3 |
Aliases | FLJ90440; KIAA3016; LIG-3; Leucine-rich repeats and immunoglobulin-like domains protein 3 |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LRIG3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LRIG3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LRIG3 |
Name | leucine-rich repeats and immunoglobulin-like domains 3 |
Aliases | FLJ90440; KIAA3016; LIG-3; Leucine-rich repeats and immunoglobulin-like domains protein 3 |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LRIG3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | LRIG3 |
Name | leucine-rich repeats and immunoglobulin-like domains 3 |
Aliases | FLJ90440; KIAA3016; LIG-3; Leucine-rich repeats and immunoglobulin-like domains protein 3 |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LRIG3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | LRIG3 |
Name | leucine-rich repeats and immunoglobulin-like domains 3 |
Aliases | FLJ90440; KIAA3016; LIG-3; Leucine-rich repeats and immunoglobulin-like domains protein 3 |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LRIG3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | LRIG3 |
Name | leucine-rich repeats and immunoglobulin-like domains 3 |
Aliases | FLJ90440; KIAA3016; LIG-3; Leucine-rich repeats and immunoglobulin-like domains protein 3 |
Chromosomal Location | 12q14.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LRIG3 collected from DrugBank database. |
There is no record. |