Summary | |
---|---|
Symbol | LRP10 |
Name | low density lipoprotein receptor-related protein 10 |
Aliases | DKFZP564C1940; MGC8675; MST087; MSTP087; LRP-10; Low-density lipoprotein receptor-related protein 10 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type I membrane protein Membrane, coated pit |
Domain |
PF00431 CUB domain PF00057 Low-density lipoprotein receptor domain class A |
Function |
Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity). |
Biological Process |
GO:0006869 lipid transport GO:0006898 receptor-mediated endocytosis GO:0007423 sensory organ development GO:0010876 lipid localization GO:0043583 ear development GO:0048839 inner ear development |
Molecular Function |
GO:0005041 low-density lipoprotein receptor activity GO:0030228 lipoprotein particle receptor activity GO:0038024 cargo receptor activity |
Cellular Component |
GO:0005905 clathrin-coated pit GO:0098589 membrane region |
KEGG | - |
Reactome |
R-HSA-1430728: Metabolism R-HSA-6806667: Metabolism of fat-soluble vitamins R-HSA-196854: Metabolism of vitamins and cofactors R-HSA-975634: Retinoid metabolism and transport R-HSA-162582: Signal Transduction R-HSA-2187338: Visual phototransduction |
Summary | |
---|---|
Symbol | LRP10 |
Name | low density lipoprotein receptor-related protein 10 |
Aliases | DKFZP564C1940; MGC8675; MST087; MSTP087; LRP-10; Low-density lipoprotein receptor-related protein 10 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LRP10 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | LRP10 |
Name | low density lipoprotein receptor-related protein 10 |
Aliases | DKFZP564C1940; MGC8675; MST087; MSTP087; LRP-10; Low-density lipoprotein receptor-related protein 10 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of LRP10 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | LRP10 |
Name | low density lipoprotein receptor-related protein 10 |
Aliases | DKFZP564C1940; MGC8675; MST087; MSTP087; LRP-10; Low-density lipoprotein receptor-related protein 10 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LRP10 in various data sets.
|
Points in the above scatter plot represent the mutation difference of LRP10 in various data sets.
|
Summary | |
---|---|
Symbol | LRP10 |
Name | low density lipoprotein receptor-related protein 10 |
Aliases | DKFZP564C1940; MGC8675; MST087; MSTP087; LRP-10; Low-density lipoprotein receptor-related protein 10 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LRP10. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | LRP10 |
Name | low density lipoprotein receptor-related protein 10 |
Aliases | DKFZP564C1940; MGC8675; MST087; MSTP087; LRP-10; Low-density lipoprotein receptor-related protein 10 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LRP10. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LRP10. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | LRP10 |
Name | low density lipoprotein receptor-related protein 10 |
Aliases | DKFZP564C1940; MGC8675; MST087; MSTP087; LRP-10; Low-density lipoprotein receptor-related protein 10 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LRP10. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | LRP10 |
Name | low density lipoprotein receptor-related protein 10 |
Aliases | DKFZP564C1940; MGC8675; MST087; MSTP087; LRP-10; Low-density lipoprotein receptor-related protein 10 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LRP10 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | LRP10 |
Name | low density lipoprotein receptor-related protein 10 |
Aliases | DKFZP564C1940; MGC8675; MST087; MSTP087; LRP-10; Low-density lipoprotein receptor-related protein 10 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LRP10 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | LRP10 |
Name | low density lipoprotein receptor-related protein 10 |
Aliases | DKFZP564C1940; MGC8675; MST087; MSTP087; LRP-10; Low-density lipoprotein receptor-related protein 10 |
Chromosomal Location | 14q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LRP10 collected from DrugBank database. |
There is no record. |