Summary | |
---|---|
Symbol | LSR |
Name | lipolysis stimulated lipoprotein receptor |
Aliases | LISCH7; ILDR3; lipolysis-stimulated remnant; immunoglobulin-like domain containing receptor 3; LISCH protein ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass membrane protein |
Domain |
PF05624 Lipolysis stimulated receptor (LSR) |
Function |
Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). |
Biological Process |
GO:0001889 liver development GO:0007043 cell-cell junction assembly GO:0019216 regulation of lipid metabolic process GO:0034329 cell junction assembly GO:0034330 cell junction organization GO:0045216 cell-cell junction organization GO:0048732 gland development GO:0060856 establishment of blood-brain barrier GO:0061008 hepaticobiliary system development GO:1904274 tricellular tight junction assembly |
Molecular Function | - |
Cellular Component |
GO:0032994 protein-lipid complex GO:0034358 plasma lipoprotein particle GO:0034361 very-low-density lipoprotein particle GO:0034362 low-density lipoprotein particle GO:0034385 triglyceride-rich lipoprotein particle GO:0042627 chylomicron GO:0061689 tricellular tight junction GO:0070160 occluding junction GO:1990777 lipoprotein particle |
KEGG | - |
Reactome |
R-HSA-171052: LDL-mediated lipid transport R-HSA-73923: Lipid digestion, mobilization, and transport R-HSA-174824: Lipoprotein metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-8855121: VLDL interactions |
Summary | |
---|---|
Symbol | LSR |
Name | lipolysis stimulated lipoprotein receptor |
Aliases | LISCH7; ILDR3; lipolysis-stimulated remnant; immunoglobulin-like domain containing receptor 3; LISCH protein ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LSR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | LSR |
Name | lipolysis stimulated lipoprotein receptor |
Aliases | LISCH7; ILDR3; lipolysis-stimulated remnant; immunoglobulin-like domain containing receptor 3; LISCH protein ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LSR in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | LSR |
Name | lipolysis stimulated lipoprotein receptor |
Aliases | LISCH7; ILDR3; lipolysis-stimulated remnant; immunoglobulin-like domain containing receptor 3; LISCH protein ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LSR in various data sets.
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Points in the above scatter plot represent the mutation difference of LSR in various data sets.
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Summary | |
---|---|
Symbol | LSR |
Name | lipolysis stimulated lipoprotein receptor |
Aliases | LISCH7; ILDR3; lipolysis-stimulated remnant; immunoglobulin-like domain containing receptor 3; LISCH protein ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LSR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | LSR |
Name | lipolysis stimulated lipoprotein receptor |
Aliases | LISCH7; ILDR3; lipolysis-stimulated remnant; immunoglobulin-like domain containing receptor 3; LISCH protein ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LSR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LSR. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | LSR |
Name | lipolysis stimulated lipoprotein receptor |
Aliases | LISCH7; ILDR3; lipolysis-stimulated remnant; immunoglobulin-like domain containing receptor 3; LISCH protein ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LSR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | LSR |
Name | lipolysis stimulated lipoprotein receptor |
Aliases | LISCH7; ILDR3; lipolysis-stimulated remnant; immunoglobulin-like domain containing receptor 3; LISCH protein ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LSR expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | LSR |
Name | lipolysis stimulated lipoprotein receptor |
Aliases | LISCH7; ILDR3; lipolysis-stimulated remnant; immunoglobulin-like domain containing receptor 3; LISCH protein ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LSR and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | LSR |
Name | lipolysis stimulated lipoprotein receptor |
Aliases | LISCH7; ILDR3; lipolysis-stimulated remnant; immunoglobulin-like domain containing receptor 3; LISCH protein ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LSR collected from DrugBank database. |
There is no record. |