Summary | |
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Symbol | LTA |
Name | lymphotoxin alpha |
Aliases | TNFSF1; LT; TNF superfamily member 1; TNFB; lymphotoxin alpha (TNF superfamily, member 1); LT-alpha; TNF sup ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated. |
Domain |
PF00229 TNF(Tumour Necrosis Factor) family |
Function |
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. |
Biological Process |
GO:0001666 response to hypoxia GO:0001819 positive regulation of cytokine production GO:0002237 response to molecule of bacterial origin GO:0002250 adaptive immune response GO:0002437 inflammatory response to antigenic stimulus GO:0002439 chronic inflammatory response to antigenic stimulus GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002455 humoral immune response mediated by circulating immunoglobulin GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002544 chronic inflammatory response GO:0002676 regulation of chronic inflammatory response GO:0002678 positive regulation of chronic inflammatory response GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002703 regulation of leukocyte mediated immunity GO:0002705 positive regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002708 positive regulation of lymphocyte mediated immunity GO:0002712 regulation of B cell mediated immunity GO:0002714 positive regulation of B cell mediated immunity GO:0002819 regulation of adaptive immune response GO:0002821 positive regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002861 regulation of inflammatory response to antigenic stimulus GO:0002863 positive regulation of inflammatory response to antigenic stimulus GO:0002874 regulation of chronic inflammatory response to antigenic stimulus GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002889 regulation of immunoglobulin mediated immune response GO:0002891 positive regulation of immunoglobulin mediated immune response GO:0002920 regulation of humoral immune response GO:0002922 positive regulation of humoral immune response GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0006959 humoral immune response GO:0007584 response to nutrient GO:0009991 response to extracellular stimulus GO:0010720 positive regulation of cell development GO:0014009 glial cell proliferation GO:0014013 regulation of gliogenesis GO:0014015 positive regulation of gliogenesis GO:0016064 immunoglobulin mediated immune response GO:0019724 B cell mediated immunity GO:0031349 positive regulation of defense response GO:0031667 response to nutrient levels GO:0032103 positive regulation of response to external stimulus GO:0032496 response to lipopolysaccharide GO:0032609 interferon-gamma production GO:0032649 regulation of interferon-gamma production GO:0032729 positive regulation of interferon-gamma production GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0034612 response to tumor necrosis factor GO:0036293 response to decreased oxygen levels GO:0042063 gliogenesis GO:0042493 response to drug GO:0042742 defense response to bacterium GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044110 growth involved in symbiotic interaction GO:0044116 growth of symbiont involved in interaction with host GO:0044117 growth of symbiont in host GO:0044126 regulation of growth of symbiont in host GO:0044130 negative regulation of growth of symbiont in host GO:0044144 modulation of growth of symbiont involved in interaction with host GO:0044146 negative regulation of growth of symbiont involved in interaction with host GO:0045926 negative regulation of growth GO:0048144 fibroblast proliferation GO:0048145 regulation of fibroblast proliferation GO:0048147 negative regulation of fibroblast proliferation GO:0048535 lymph node development GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050769 positive regulation of neurogenesis GO:0050830 defense response to Gram-positive bacterium GO:0051962 positive regulation of nervous system development GO:0060251 regulation of glial cell proliferation GO:0060252 positive regulation of glial cell proliferation GO:0070482 response to oxygen levels GO:0071356 cellular response to tumor necrosis factor GO:0098542 defense response to other organism |
Molecular Function |
GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005164 tumor necrosis factor receptor binding GO:0032813 tumor necrosis factor receptor superfamily binding |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04064 NF-kappa B signaling pathway hsa04668 TNF signaling pathway |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-5676594: TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5668541: TNFR2 non-canonical NF-kB pathway R-HSA-5669034: TNFs bind their physiological receptors |
Summary | |
---|---|
Symbol | LTA |
Name | lymphotoxin alpha |
Aliases | TNFSF1; LT; TNF superfamily member 1; TNFB; lymphotoxin alpha (TNF superfamily, member 1); LT-alpha; TNF sup ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LTA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between LTA and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | LTA |
Name | lymphotoxin alpha |
Aliases | TNFSF1; LT; TNF superfamily member 1; TNFB; lymphotoxin alpha (TNF superfamily, member 1); LT-alpha; TNF sup ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LTA in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LTA |
Name | lymphotoxin alpha |
Aliases | TNFSF1; LT; TNF superfamily member 1; TNFB; lymphotoxin alpha (TNF superfamily, member 1); LT-alpha; TNF sup ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LTA in various data sets.
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Points in the above scatter plot represent the mutation difference of LTA in various data sets.
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Summary | |
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Symbol | LTA |
Name | lymphotoxin alpha |
Aliases | TNFSF1; LT; TNF superfamily member 1; TNFB; lymphotoxin alpha (TNF superfamily, member 1); LT-alpha; TNF sup ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LTA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | LTA |
Name | lymphotoxin alpha |
Aliases | TNFSF1; LT; TNF superfamily member 1; TNFB; lymphotoxin alpha (TNF superfamily, member 1); LT-alpha; TNF sup ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LTA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LTA. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LTA |
Name | lymphotoxin alpha |
Aliases | TNFSF1; LT; TNF superfamily member 1; TNFB; lymphotoxin alpha (TNF superfamily, member 1); LT-alpha; TNF sup ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LTA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | LTA |
Name | lymphotoxin alpha |
Aliases | TNFSF1; LT; TNF superfamily member 1; TNFB; lymphotoxin alpha (TNF superfamily, member 1); LT-alpha; TNF sup ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LTA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | LTA |
Name | lymphotoxin alpha |
Aliases | TNFSF1; LT; TNF superfamily member 1; TNFB; lymphotoxin alpha (TNF superfamily, member 1); LT-alpha; TNF sup ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LTA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | LTA |
Name | lymphotoxin alpha |
Aliases | TNFSF1; LT; TNF superfamily member 1; TNFB; lymphotoxin alpha (TNF superfamily, member 1); LT-alpha; TNF sup ...... |
Chromosomal Location | 6p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LTA collected from DrugBank database. |
Details on drugs targeting LTA.
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