Summary | |
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Symbol | LTA4H |
Name | leukotriene A4 hydrolase |
Aliases | LTA-4 hydrolase; Leukotriene A(4) hydrolase; Leukotriene A-4 hydrolase |
Chromosomal Location | 12q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. |
Domain |
PF09127 Leukotriene A4 hydrolase PF01433 Peptidase family M1 |
Function |
Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. |
Biological Process |
GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0006636 unsaturated fatty acid biosynthetic process GO:0006690 icosanoid metabolic process GO:0006691 leukotriene metabolic process GO:0016053 organic acid biosynthetic process GO:0019370 leukotriene biosynthetic process GO:0033559 unsaturated fatty acid metabolic process GO:0043171 peptide catabolic process GO:0044283 small molecule biosynthetic process GO:0046394 carboxylic acid biosynthetic process GO:0046456 icosanoid biosynthetic process GO:0072330 monocarboxylic acid biosynthetic process GO:1901565 organonitrogen compound catabolic process |
Molecular Function |
GO:0004177 aminopeptidase activity GO:0004301 epoxide hydrolase activity GO:0004463 leukotriene-A4 hydrolase activity GO:0008235 metalloexopeptidase activity GO:0008237 metallopeptidase activity GO:0008238 exopeptidase activity GO:0016801 hydrolase activity, acting on ether bonds GO:0016803 ether hydrolase activity GO:0033218 amide binding GO:0042277 peptide binding GO:0070006 metalloaminopeptidase activity |
Cellular Component | - |
KEGG |
hsa00590 Arachidonic acid metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-2142753: Arachidonic acid metabolism R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-6798695: Neutrophil degranulation R-HSA-2142691: Synthesis of Leukotrienes (LT) and Eoxins (EX) |
Summary | |
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Symbol | LTA4H |
Name | leukotriene A4 hydrolase |
Aliases | LTA-4 hydrolase; Leukotriene A(4) hydrolase; Leukotriene A-4 hydrolase |
Chromosomal Location | 12q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LTA4H and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | LTA4H |
Name | leukotriene A4 hydrolase |
Aliases | LTA-4 hydrolase; Leukotriene A(4) hydrolase; Leukotriene A-4 hydrolase |
Chromosomal Location | 12q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LTA4H in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LTA4H |
Name | leukotriene A4 hydrolase |
Aliases | LTA-4 hydrolase; Leukotriene A(4) hydrolase; Leukotriene A-4 hydrolase |
Chromosomal Location | 12q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LTA4H in various data sets.
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Points in the above scatter plot represent the mutation difference of LTA4H in various data sets.
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Summary | |
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Symbol | LTA4H |
Name | leukotriene A4 hydrolase |
Aliases | LTA-4 hydrolase; Leukotriene A(4) hydrolase; Leukotriene A-4 hydrolase |
Chromosomal Location | 12q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LTA4H. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | LTA4H |
Name | leukotriene A4 hydrolase |
Aliases | LTA-4 hydrolase; Leukotriene A(4) hydrolase; Leukotriene A-4 hydrolase |
Chromosomal Location | 12q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LTA4H. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LTA4H. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LTA4H |
Name | leukotriene A4 hydrolase |
Aliases | LTA-4 hydrolase; Leukotriene A(4) hydrolase; Leukotriene A-4 hydrolase |
Chromosomal Location | 12q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LTA4H. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | LTA4H |
Name | leukotriene A4 hydrolase |
Aliases | LTA-4 hydrolase; Leukotriene A(4) hydrolase; Leukotriene A-4 hydrolase |
Chromosomal Location | 12q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LTA4H expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | LTA4H |
Name | leukotriene A4 hydrolase |
Aliases | LTA-4 hydrolase; Leukotriene A(4) hydrolase; Leukotriene A-4 hydrolase |
Chromosomal Location | 12q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LTA4H and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | LTA4H |
Name | leukotriene A4 hydrolase |
Aliases | LTA-4 hydrolase; Leukotriene A(4) hydrolase; Leukotriene A-4 hydrolase |
Chromosomal Location | 12q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LTA4H collected from DrugBank database. |
Details on drugs targeting LTA4H.
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