Summary | |
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Symbol | LURAP1 |
Name | leucine rich adaptor protein 1 |
Aliases | FLJ25163; LRAP35a; leucine repeat adaptor protein 35a; C1orf190; chromosome 1 open reading frame 190; LRP35A ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm |
Domain | - |
Function |
Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (PubMed:21048106). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity). |
Biological Process |
GO:0001819 positive regulation of cytokine production GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0031032 actomyosin structure organization GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling |
Molecular Function | - |
Cellular Component |
GO:0015629 actin cytoskeleton GO:0042641 actomyosin |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | LURAP1 |
Name | leucine rich adaptor protein 1 |
Aliases | FLJ25163; LRAP35a; leucine repeat adaptor protein 35a; C1orf190; chromosome 1 open reading frame 190; LRP35A ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LURAP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | LURAP1 |
Name | leucine rich adaptor protein 1 |
Aliases | FLJ25163; LRAP35a; leucine repeat adaptor protein 35a; C1orf190; chromosome 1 open reading frame 190; LRP35A ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LURAP1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | LURAP1 |
Name | leucine rich adaptor protein 1 |
Aliases | FLJ25163; LRAP35a; leucine repeat adaptor protein 35a; C1orf190; chromosome 1 open reading frame 190; LRP35A ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LURAP1 in various data sets.
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Points in the above scatter plot represent the mutation difference of LURAP1 in various data sets.
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Summary | |
---|---|
Symbol | LURAP1 |
Name | leucine rich adaptor protein 1 |
Aliases | FLJ25163; LRAP35a; leucine repeat adaptor protein 35a; C1orf190; chromosome 1 open reading frame 190; LRP35A ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LURAP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | LURAP1 |
Name | leucine rich adaptor protein 1 |
Aliases | FLJ25163; LRAP35a; leucine repeat adaptor protein 35a; C1orf190; chromosome 1 open reading frame 190; LRP35A ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LURAP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LURAP1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | LURAP1 |
Name | leucine rich adaptor protein 1 |
Aliases | FLJ25163; LRAP35a; leucine repeat adaptor protein 35a; C1orf190; chromosome 1 open reading frame 190; LRP35A ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LURAP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | LURAP1 |
Name | leucine rich adaptor protein 1 |
Aliases | FLJ25163; LRAP35a; leucine repeat adaptor protein 35a; C1orf190; chromosome 1 open reading frame 190; LRP35A ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LURAP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | LURAP1 |
Name | leucine rich adaptor protein 1 |
Aliases | FLJ25163; LRAP35a; leucine repeat adaptor protein 35a; C1orf190; chromosome 1 open reading frame 190; LRP35A ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LURAP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | LURAP1 |
Name | leucine rich adaptor protein 1 |
Aliases | FLJ25163; LRAP35a; leucine repeat adaptor protein 35a; C1orf190; chromosome 1 open reading frame 190; LRP35A ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LURAP1 collected from DrugBank database. |
There is no record. |