Summary | |
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Symbol | LY6H |
Name | lymphocyte antigen 6 complex, locus H |
Aliases | NMLY6; ly-6H; Lymphocyte antigen 6H |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Lipid-anchor, GPI-anchor |
Domain |
PF00021 u-PAR/Ly-6 domain |
Function |
Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. |
Biological Process | - |
Molecular Function | - |
Cellular Component |
GO:0031225 anchored component of membrane |
KEGG | - |
Reactome |
R-HSA-392499: Metabolism of proteins R-HSA-163125: Post-translational modification R-HSA-597592: Post-translational protein modification |
Summary | |
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Symbol | LY6H |
Name | lymphocyte antigen 6 complex, locus H |
Aliases | NMLY6; ly-6H; Lymphocyte antigen 6H |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LY6H and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | LY6H |
Name | lymphocyte antigen 6 complex, locus H |
Aliases | NMLY6; ly-6H; Lymphocyte antigen 6H |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LY6H in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LY6H |
Name | lymphocyte antigen 6 complex, locus H |
Aliases | NMLY6; ly-6H; Lymphocyte antigen 6H |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LY6H in various data sets.
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Points in the above scatter plot represent the mutation difference of LY6H in various data sets.
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Summary | |
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Symbol | LY6H |
Name | lymphocyte antigen 6 complex, locus H |
Aliases | NMLY6; ly-6H; Lymphocyte antigen 6H |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LY6H. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | LY6H |
Name | lymphocyte antigen 6 complex, locus H |
Aliases | NMLY6; ly-6H; Lymphocyte antigen 6H |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LY6H. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LY6H. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LY6H |
Name | lymphocyte antigen 6 complex, locus H |
Aliases | NMLY6; ly-6H; Lymphocyte antigen 6H |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LY6H. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | LY6H |
Name | lymphocyte antigen 6 complex, locus H |
Aliases | NMLY6; ly-6H; Lymphocyte antigen 6H |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LY6H expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | LY6H |
Name | lymphocyte antigen 6 complex, locus H |
Aliases | NMLY6; ly-6H; Lymphocyte antigen 6H |
Chromosomal Location | 8q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LY6H and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |