Summary | |
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Symbol | LYG2 |
Name | lysozyme G-like 2 |
Aliases | LYGH; Lysozyme g-like protein 2 |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain | - |
Function |
May act as a potent antibacterial protein that may play a role in the innate immunity. |
Biological Process |
GO:0000270 peptidoglycan metabolic process GO:0006022 aminoglycan metabolic process GO:0006026 aminoglycan catabolic process GO:0006027 glycosaminoglycan catabolic process GO:0009253 peptidoglycan catabolic process GO:0016998 cell wall macromolecule catabolic process GO:0030203 glycosaminoglycan metabolic process GO:0044036 cell wall macromolecule metabolic process GO:0071554 cell wall organization or biogenesis GO:1901136 carbohydrate derivative catabolic process GO:1901565 organonitrogen compound catabolic process |
Molecular Function |
GO:0003796 lysozyme activity GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0061783 peptidoglycan muralytic activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | LYG2 |
Name | lysozyme G-like 2 |
Aliases | LYGH; Lysozyme g-like protein 2 |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LYG2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | LYG2 |
Name | lysozyme G-like 2 |
Aliases | LYGH; Lysozyme g-like protein 2 |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LYG2 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | LYG2 |
Name | lysozyme G-like 2 |
Aliases | LYGH; Lysozyme g-like protein 2 |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LYG2 in various data sets.
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Points in the above scatter plot represent the mutation difference of LYG2 in various data sets.
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Summary | |
---|---|
Symbol | LYG2 |
Name | lysozyme G-like 2 |
Aliases | LYGH; Lysozyme g-like protein 2 |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LYG2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | LYG2 |
Name | lysozyme G-like 2 |
Aliases | LYGH; Lysozyme g-like protein 2 |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LYG2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LYG2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LYG2 |
Name | lysozyme G-like 2 |
Aliases | LYGH; Lysozyme g-like protein 2 |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LYG2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | LYG2 |
Name | lysozyme G-like 2 |
Aliases | LYGH; Lysozyme g-like protein 2 |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LYG2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | LYG2 |
Name | lysozyme G-like 2 |
Aliases | LYGH; Lysozyme g-like protein 2 |
Chromosomal Location | 2q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LYG2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |