Summary | |
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Symbol | LYPLAL1 |
Name | lysophospholipase-like 1 |
Aliases | Q96AV0; Lysophospholipase-like protein 1 |
Chromosomal Location | 1q41 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Cytoplasm, cytosol ; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, cytosol |
Domain |
PF02230 Phospholipase/Carboxylesterase |
Function |
Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site. |
Biological Process |
GO:0002084 protein depalmitoylation GO:0035601 protein deacylation GO:0042157 lipoprotein metabolic process GO:0042159 lipoprotein catabolic process GO:0098732 macromolecule deacylation GO:0098734 macromolecule depalmitoylation |
Molecular Function |
GO:0004620 phospholipase activity GO:0004622 lysophospholipase activity GO:0008474 palmitoyl-(protein) hydrolase activity GO:0016298 lipase activity GO:0016790 thiolester hydrolase activity GO:0052689 carboxylic ester hydrolase activity GO:0098599 palmitoyl hydrolase activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | LYPLAL1 |
Name | lysophospholipase-like 1 |
Aliases | Q96AV0; Lysophospholipase-like protein 1 |
Chromosomal Location | 1q41 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LYPLAL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | LYPLAL1 |
Name | lysophospholipase-like 1 |
Aliases | Q96AV0; Lysophospholipase-like protein 1 |
Chromosomal Location | 1q41 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LYPLAL1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | LYPLAL1 |
Name | lysophospholipase-like 1 |
Aliases | Q96AV0; Lysophospholipase-like protein 1 |
Chromosomal Location | 1q41 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LYPLAL1 in various data sets.
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Points in the above scatter plot represent the mutation difference of LYPLAL1 in various data sets.
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Summary | |
---|---|
Symbol | LYPLAL1 |
Name | lysophospholipase-like 1 |
Aliases | Q96AV0; Lysophospholipase-like protein 1 |
Chromosomal Location | 1q41 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LYPLAL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | LYPLAL1 |
Name | lysophospholipase-like 1 |
Aliases | Q96AV0; Lysophospholipase-like protein 1 |
Chromosomal Location | 1q41 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LYPLAL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LYPLAL1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | LYPLAL1 |
Name | lysophospholipase-like 1 |
Aliases | Q96AV0; Lysophospholipase-like protein 1 |
Chromosomal Location | 1q41 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LYPLAL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | LYPLAL1 |
Name | lysophospholipase-like 1 |
Aliases | Q96AV0; Lysophospholipase-like protein 1 |
Chromosomal Location | 1q41 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LYPLAL1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | LYPLAL1 |
Name | lysophospholipase-like 1 |
Aliases | Q96AV0; Lysophospholipase-like protein 1 |
Chromosomal Location | 1q41 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LYPLAL1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |