Summary | |
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Symbol | MAD2L1 |
Name | MAD2 mitotic arrest deficient-like 1 (yeast) |
Aliases | MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like protein 1; mitotic arrest deficient 2-like ...... |
Chromosomal Location | 4q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Chromosome, centromere, kinetochore. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Recruited by MAD1L1 to unattached kinetochores (Probable). Recruited to the nuclear pore complex by TPR during interphase. Recruited to kinetochores in late prometaphase after BUB1, CENPF, BUB1B and CENPE. Kinetochore association requires the presence of NEK2. Kinetochore association is repressed by UBD. |
Domain |
PF02301 HORMA domain |
Function |
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. |
Biological Process |
GO:0000070 mitotic sister chromatid segregation GO:0000075 cell cycle checkpoint GO:0000819 sister chromatid segregation GO:0007059 chromosome segregation GO:0007062 sister chromatid cohesion GO:0007067 mitotic nuclear division GO:0007088 regulation of mitotic nuclear division GO:0007091 metaphase/anaphase transition of mitotic cell cycle GO:0007093 mitotic cell cycle checkpoint GO:0007094 mitotic spindle assembly checkpoint GO:0007346 regulation of mitotic cell cycle GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0010498 proteasomal protein catabolic process GO:0010639 negative regulation of organelle organization GO:0010948 negative regulation of cell cycle process GO:0010965 regulation of mitotic sister chromatid separation GO:0030071 regulation of mitotic metaphase/anaphase transition GO:0031145 anaphase-promoting complex-dependent catabolic process GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031396 regulation of protein ubiquitination GO:0031397 negative regulation of protein ubiquitination GO:0031398 positive regulation of protein ubiquitination GO:0031577 spindle checkpoint GO:0033044 regulation of chromosome organization GO:0033045 regulation of sister chromatid segregation GO:0033046 negative regulation of sister chromatid segregation GO:0033047 regulation of mitotic sister chromatid segregation GO:0033048 negative regulation of mitotic sister chromatid segregation GO:0042176 regulation of protein catabolic process GO:0042177 negative regulation of protein catabolic process GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044784 metaphase/anaphase transition of cell cycle GO:0045732 positive regulation of protein catabolic process GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045839 negative regulation of mitotic nuclear division GO:0045841 negative regulation of mitotic metaphase/anaphase transition GO:0045862 positive regulation of proteolysis GO:0045930 negative regulation of mitotic cell cycle GO:0045931 positive regulation of mitotic cell cycle GO:0051304 chromosome separation GO:0051306 mitotic sister chromatid separation GO:0051348 negative regulation of transferase activity GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition GO:0051438 regulation of ubiquitin-protein transferase activity GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051443 positive regulation of ubiquitin-protein transferase activity GO:0051444 negative regulation of ubiquitin-protein transferase activity GO:0051783 regulation of nuclear division GO:0051784 negative regulation of nuclear division GO:0051983 regulation of chromosome segregation GO:0051985 negative regulation of chromosome segregation GO:0071173 spindle assembly checkpoint GO:0071174 mitotic spindle checkpoint GO:0090068 positive regulation of cell cycle process GO:0090231 regulation of spindle checkpoint GO:0090232 positive regulation of spindle checkpoint GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint GO:0098813 nuclear chromosome segregation GO:1901976 regulation of cell cycle checkpoint GO:1901978 positive regulation of cell cycle checkpoint GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901991 negative regulation of mitotic cell cycle phase transition GO:1902099 regulation of metaphase/anaphase transition of cell cycle GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process GO:1903320 regulation of protein modification by small protein conjugation or removal GO:1903321 negative regulation of protein modification by small protein conjugation or removal GO:1903322 positive regulation of protein modification by small protein conjugation or removal GO:1903362 regulation of cellular protein catabolic process GO:1903364 positive regulation of cellular protein catabolic process GO:1903504 regulation of mitotic spindle checkpoint GO:1904666 regulation of ubiquitin protein ligase activity GO:1904667 negative regulation of ubiquitin protein ligase activity GO:1904668 positive regulation of ubiquitin protein ligase activity GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000816 negative regulation of mitotic sister chromatid separation GO:2001251 negative regulation of chromosome organization |
Molecular Function | - |
Cellular Component |
GO:0000775 chromosome, centromeric region GO:0000776 kinetochore GO:0000777 condensed chromosome kinetochore GO:0000779 condensed chromosome, centromeric region GO:0000793 condensed chromosome GO:0000922 spindle pole GO:0005635 nuclear envelope GO:0005643 nuclear pore GO:0005819 spindle GO:0072686 mitotic spindle GO:0098687 chromosomal region |
KEGG |
hsa04110 Cell cycle hsa04114 Oocyte meiosis hsa04914 Progesterone-mediated oocyte maturation |
Reactome |
R-HSA-179409: APC-Cdc20 mediated degradation of Nek2A R-HSA-174143: APC/C-mediated degradation of cell cycle proteins R-HSA-176409: APC/C R-HSA-179419: APC R-HSA-176814: Activation of APC/C and APC/C R-HSA-141444: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-141424: Amplification of signal from the kinetochores R-HSA-174184: Cdc20 R-HSA-1640170: Cell Cycle R-HSA-69620: Cell Cycle Checkpoints R-HSA-69278: Cell Cycle, Mitotic R-HSA-141430: Inactivation of APC/C via direct inhibition of the APC/C complex R-HSA-141405: Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components R-HSA-68886: M Phase R-HSA-68882: Mitotic Anaphase R-HSA-2555396: Mitotic Metaphase and Anaphase R-HSA-68877: Mitotic Prometaphase R-HSA-69618: Mitotic Spindle Checkpoint R-HSA-195258: RHO GTPase Effectors R-HSA-5663220: RHO GTPases Activate Formins R-HSA-176408: Regulation of APC/C activators between G1/S and early anaphase R-HSA-453276: Regulation of mitotic cell cycle R-HSA-2500257: Resolution of Sister Chromatid Cohesion R-HSA-2467813: Separation of Sister Chromatids R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases |
Summary | |
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Symbol | MAD2L1 |
Name | MAD2 mitotic arrest deficient-like 1 (yeast) |
Aliases | MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like protein 1; mitotic arrest deficient 2-like ...... |
Chromosomal Location | 4q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MAD2L1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MAD2L1 |
Name | MAD2 mitotic arrest deficient-like 1 (yeast) |
Aliases | MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like protein 1; mitotic arrest deficient 2-like ...... |
Chromosomal Location | 4q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MAD2L1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MAD2L1 |
Name | MAD2 mitotic arrest deficient-like 1 (yeast) |
Aliases | MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like protein 1; mitotic arrest deficient 2-like ...... |
Chromosomal Location | 4q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MAD2L1 in various data sets.
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Points in the above scatter plot represent the mutation difference of MAD2L1 in various data sets.
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Summary | |
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Symbol | MAD2L1 |
Name | MAD2 mitotic arrest deficient-like 1 (yeast) |
Aliases | MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like protein 1; mitotic arrest deficient 2-like ...... |
Chromosomal Location | 4q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MAD2L1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MAD2L1 |
Name | MAD2 mitotic arrest deficient-like 1 (yeast) |
Aliases | MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like protein 1; mitotic arrest deficient 2-like ...... |
Chromosomal Location | 4q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MAD2L1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MAD2L1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MAD2L1 |
Name | MAD2 mitotic arrest deficient-like 1 (yeast) |
Aliases | MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like protein 1; mitotic arrest deficient 2-like ...... |
Chromosomal Location | 4q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MAD2L1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MAD2L1 |
Name | MAD2 mitotic arrest deficient-like 1 (yeast) |
Aliases | MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like protein 1; mitotic arrest deficient 2-like ...... |
Chromosomal Location | 4q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MAD2L1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | MAD2L1 |
Name | MAD2 mitotic arrest deficient-like 1 (yeast) |
Aliases | MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like protein 1; mitotic arrest deficient 2-like ...... |
Chromosomal Location | 4q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MAD2L1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | MAD2L1 |
Name | MAD2 mitotic arrest deficient-like 1 (yeast) |
Aliases | MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like protein 1; mitotic arrest deficient 2-like ...... |
Chromosomal Location | 4q27 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MAD2L1 collected from DrugBank database. |
There is no record. |