Summary | |
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Symbol | MAN2A1 |
Name | mannosidase, alpha, class 2A, member 1 |
Aliases | GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ...... |
Chromosomal Location | 5q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus membrane Single-pass type II membrane protein |
Domain |
PF09261 Alpha mannosidase middle domain PF01074 Glycosyl hydrolases family 38 N-terminal domain PF07748 Glycosyl hydrolases family 38 C-terminal domain |
Function |
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. |
Biological Process |
GO:0001654 eye development GO:0001701 in utero embryonic development GO:0001889 liver development GO:0005996 monosaccharide metabolic process GO:0006013 mannose metabolic process GO:0006486 protein glycosylation GO:0006487 protein N-linked glycosylation GO:0006491 N-glycan processing GO:0006517 protein deglycosylation GO:0007033 vacuole organization GO:0007423 sensory organ development GO:0007585 respiratory gaseous exchange GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0009311 oligosaccharide metabolic process GO:0010720 positive regulation of cell development GO:0019318 hexose metabolic process GO:0030323 respiratory tube development GO:0030324 lung development GO:0043010 camera-type eye development GO:0043413 macromolecule glycosylation GO:0044723 single-organism carbohydrate metabolic process GO:0048286 lung alveolus development GO:0048592 eye morphogenesis GO:0048593 camera-type eye morphogenesis GO:0048732 gland development GO:0050769 positive regulation of neurogenesis GO:0051962 positive regulation of nervous system development GO:0060041 retina development in camera-type eye GO:0060042 retina morphogenesis in camera-type eye GO:0060541 respiratory system development GO:0061008 hepaticobiliary system development GO:0070085 glycosylation GO:0090596 sensory organ morphogenesis |
Molecular Function |
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004559 alpha-mannosidase activity GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity GO:0015923 mannosidase activity GO:0015924 mannosyl-oligosaccharide mannosidase activity GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds GO:0030246 carbohydrate binding |
Cellular Component |
GO:0005801 cis-Golgi network |
KEGG |
hsa00510 N-Glycan biosynthesis hsa01100 Metabolic pathways |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811438: Intra-Golgi traffic R-HSA-199991: Membrane Trafficking R-HSA-392499: Metabolism of proteins R-HSA-975576: N-glycan antennae elongation in the medial/trans-Golgi R-HSA-597592: Post-translational protein modification R-HSA-975578: Reactions specific to the complex N-glycan synthesis pathway R-HSA-948021: Transport to the Golgi and subsequent modification R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | MAN2A1 |
Name | mannosidase, alpha, class 2A, member 1 |
Aliases | GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ...... |
Chromosomal Location | 5q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MAN2A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | MAN2A1 |
Name | mannosidase, alpha, class 2A, member 1 |
Aliases | GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ...... |
Chromosomal Location | 5q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MAN2A1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MAN2A1 |
Name | mannosidase, alpha, class 2A, member 1 |
Aliases | GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ...... |
Chromosomal Location | 5q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MAN2A1 in various data sets.
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Points in the above scatter plot represent the mutation difference of MAN2A1 in various data sets.
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Summary | |
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Symbol | MAN2A1 |
Name | mannosidase, alpha, class 2A, member 1 |
Aliases | GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ...... |
Chromosomal Location | 5q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MAN2A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | MAN2A1 |
Name | mannosidase, alpha, class 2A, member 1 |
Aliases | GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ...... |
Chromosomal Location | 5q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MAN2A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MAN2A1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MAN2A1 |
Name | mannosidase, alpha, class 2A, member 1 |
Aliases | GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ...... |
Chromosomal Location | 5q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MAN2A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | MAN2A1 |
Name | mannosidase, alpha, class 2A, member 1 |
Aliases | GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ...... |
Chromosomal Location | 5q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MAN2A1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MAN2A1 |
Name | mannosidase, alpha, class 2A, member 1 |
Aliases | GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ...... |
Chromosomal Location | 5q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MAN2A1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | MAN2A1 |
Name | mannosidase, alpha, class 2A, member 1 |
Aliases | GOLIM7; golgi integral membrane protein 7; MANA2; AMan II; MANII; Golgi alpha-mannosidase II; mannosidase, a ...... |
Chromosomal Location | 5q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MAN2A1 collected from DrugBank database. |
Details on drugs targeting MAN2A1.
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