Summary | |
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Symbol | MAOB |
Name | monoamine oxidase B |
Aliases | MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ...... |
Chromosomal Location | Xp11.4-p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. |
Domain |
PF01593 Flavin containing amine oxidoreductase |
Function |
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. |
Biological Process |
GO:0001505 regulation of neurotransmitter levels GO:0001820 serotonin secretion GO:0002237 response to molecule of bacterial origin GO:0006584 catecholamine metabolic process GO:0006837 serotonin transport GO:0009308 amine metabolic process GO:0009636 response to toxic substance GO:0009712 catechol-containing compound metabolic process GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010044 response to aluminum ion GO:0010269 response to selenium ion GO:0014062 regulation of serotonin secretion GO:0014063 negative regulation of serotonin secretion GO:0015844 monoamine transport GO:0015850 organic hydroxy compound transport GO:0018958 phenol-containing compound metabolic process GO:0019336 phenol-containing compound catabolic process GO:0019439 aromatic compound catabolic process GO:0019614 catechol-containing compound catabolic process GO:0021762 substantia nigra development GO:0030901 midbrain development GO:0031960 response to corticosteroid GO:0032496 response to lipopolysaccharide GO:0033238 regulation of cellular amine metabolic process GO:0033240 positive regulation of cellular amine metabolic process GO:0042053 regulation of dopamine metabolic process GO:0042069 regulation of catecholamine metabolic process GO:0042133 neurotransmitter metabolic process GO:0042135 neurotransmitter catabolic process GO:0042417 dopamine metabolic process GO:0042420 dopamine catabolic process GO:0042424 catecholamine catabolic process GO:0042493 response to drug GO:0042743 hydrogen peroxide metabolic process GO:0044106 cellular amine metabolic process GO:0045471 response to ethanol GO:0045915 positive regulation of catecholamine metabolic process GO:0045964 positive regulation of dopamine metabolic process GO:0048545 response to steroid hormone GO:0048857 neural nucleus development GO:0050665 hydrogen peroxide biosynthetic process GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051384 response to glucocorticoid GO:0051385 response to mineralocorticoid GO:0051412 response to corticosterone GO:0072593 reactive oxygen species metabolic process GO:0097305 response to alcohol GO:1901361 organic cyclic compound catabolic process GO:1901565 organonitrogen compound catabolic process GO:1901615 organic hydroxy compound metabolic process GO:1901616 organic hydroxy compound catabolic process GO:1901654 response to ketone GO:1903409 reactive oxygen species biosynthetic process GO:1903531 negative regulation of secretion by cell |
Molecular Function |
GO:0008131 primary amine oxidase activity GO:0009055 electron carrier activity GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0048037 cofactor binding GO:0050660 flavin adenine dinucleotide binding GO:0050662 coenzyme binding |
Cellular Component |
GO:0005741 mitochondrial outer membrane GO:0005743 mitochondrial inner membrane GO:0019867 outer membrane GO:0031968 organelle outer membrane |
KEGG |
hsa04726 Serotonergic synapse hsa04728 Dopaminergic synapse hsa00260 Glycine, serine and threonine metabolism hsa00330 Arginine and proline metabolism hsa00340 Histidine metabolism hsa00350 Tyrosine metabolism hsa00360 Phenylalanine metabolism hsa00380 Tryptophan metabolism hsa00982 Drug metabolism - cytochrome P450 hsa01100 Metabolic pathways |
Reactome |
R-HSA-140179: Amine Oxidase reactions R-HSA-141333: Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB R-HSA-211859: Biological oxidations R-HSA-1430728: Metabolism R-HSA-211945: Phase 1 - Functionalization of compounds |
Summary | |
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Symbol | MAOB |
Name | monoamine oxidase B |
Aliases | MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ...... |
Chromosomal Location | Xp11.4-p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MAOB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MAOB |
Name | monoamine oxidase B |
Aliases | MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ...... |
Chromosomal Location | Xp11.4-p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MAOB in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | MAOB |
Name | monoamine oxidase B |
Aliases | MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ...... |
Chromosomal Location | Xp11.4-p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MAOB in various data sets.
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Points in the above scatter plot represent the mutation difference of MAOB in various data sets.
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Summary | |
---|---|
Symbol | MAOB |
Name | monoamine oxidase B |
Aliases | MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ...... |
Chromosomal Location | Xp11.4-p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MAOB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | MAOB |
Name | monoamine oxidase B |
Aliases | MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ...... |
Chromosomal Location | Xp11.4-p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MAOB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MAOB. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MAOB |
Name | monoamine oxidase B |
Aliases | MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ...... |
Chromosomal Location | Xp11.4-p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MAOB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | MAOB |
Name | monoamine oxidase B |
Aliases | MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ...... |
Chromosomal Location | Xp11.4-p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MAOB expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | MAOB |
Name | monoamine oxidase B |
Aliases | MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ...... |
Chromosomal Location | Xp11.4-p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MAOB and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | MAOB |
Name | monoamine oxidase B |
Aliases | MAO, brain; MAO, platelet; MAO-B; adrenalin oxidase; monoamine oxidase type B; tyramine oxidase; Amine oxida ...... |
Chromosomal Location | Xp11.4-p11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MAOB collected from DrugBank database. |
Details on drugs targeting MAOB.
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