Summary | |
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Symbol | MAP2K5 |
Name | mitogen-activated protein kinase kinase 5 |
Aliases | MEK5; MAPKK5; HsT17454; PRKMK5; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPKK 5; ME ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00564 PB1 domain PF00069 Protein kinase domain |
Function |
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. |
Biological Process |
GO:0000187 activation of MAPK activity GO:0001525 angiogenesis GO:0001558 regulation of cell growth GO:0001667 ameboidal-type cell migration GO:0001818 negative regulation of cytokine production GO:0002040 sprouting angiogenesis GO:0002042 cell migration involved in sprouting angiogenesis GO:0007162 negative regulation of cell adhesion GO:0007369 gastrulation GO:0007507 heart development GO:0010466 negative regulation of peptidase activity GO:0010470 regulation of gastrulation GO:0010594 regulation of endothelial cell migration GO:0010596 negative regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010633 negative regulation of epithelial cell migration GO:0010951 negative regulation of endopeptidase activity GO:0016049 cell growth GO:0016525 negative regulation of angiogenesis GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0030307 positive regulation of cell growth GO:0030336 negative regulation of cell migration GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0032147 activation of protein kinase activity GO:0032602 chemokine production GO:0032637 interleukin-8 production GO:0032642 regulation of chemokine production GO:0032677 regulation of interleukin-8 production GO:0032682 negative regulation of chemokine production GO:0032717 negative regulation of interleukin-8 production GO:0033674 positive regulation of kinase activity GO:0034113 heterotypic cell-cell adhesion GO:0034114 regulation of heterotypic cell-cell adhesion GO:0034115 negative regulation of heterotypic cell-cell adhesion GO:0034405 response to fluid shear stress GO:0034616 response to laminar fluid shear stress GO:0038034 signal transduction in absence of ligand GO:0040013 negative regulation of locomotion GO:0042035 regulation of cytokine biosynthetic process GO:0042036 negative regulation of cytokine biosynthetic process GO:0042089 cytokine biosynthetic process GO:0042107 cytokine metabolic process GO:0042228 interleukin-8 biosynthetic process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0043534 blood vessel endothelial cell migration GO:0043535 regulation of blood vessel endothelial cell migration GO:0043537 negative regulation of blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0045414 regulation of interleukin-8 biosynthetic process GO:0045415 negative regulation of interleukin-8 biosynthetic process GO:0045765 regulation of angiogenesis GO:0045860 positive regulation of protein kinase activity GO:0045861 negative regulation of proteolysis GO:0045927 positive regulation of growth GO:0045995 regulation of embryonic development GO:0048514 blood vessel morphogenesis GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051271 negative regulation of cellular component movement GO:0051346 negative regulation of hydrolase activity GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0060759 regulation of response to cytokine stimulus GO:0060761 negative regulation of response to cytokine stimulus GO:0070375 ERK5 cascade GO:0070586 cell-cell adhesion involved in gastrulation GO:0070587 regulation of cell-cell adhesion involved in gastrulation GO:0071498 cellular response to fluid shear stress GO:0071499 cellular response to laminar fluid shear stress GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072567 chemokine (C-X-C motif) ligand 2 production GO:0090049 regulation of cell migration involved in sprouting angiogenesis GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis GO:0090130 tissue migration GO:0090132 epithelium migration GO:0097191 extrinsic apoptotic signaling pathway GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO:1901099 negative regulation of signal transduction in absence of ligand GO:1901342 regulation of vasculature development GO:1901343 negative regulation of vasculature development GO:1903670 regulation of sprouting angiogenesis GO:1903671 negative regulation of sprouting angiogenesis GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000117 negative regulation of cysteine-type endopeptidase activity GO:2000146 negative regulation of cell motility GO:2000181 negative regulation of blood vessel morphogenesis GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004702 receptor signaling protein serine/threonine kinase activity GO:0004713 protein tyrosine kinase activity GO:0005057 receptor signaling protein activity |
Cellular Component |
GO:0005819 spindle |
KEGG |
hsa04010 MAPK signaling pathway hsa04540 Gap junction hsa04722 Neurotrophin signaling pathway hsa04921 Oxytocin signaling pathway |
Reactome |
R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-162582: Signal Transduction R-HSA-166520: Signalling by NGF R-HSA-198765: Signalling to ERK5 |
Summary | |
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Symbol | MAP2K5 |
Name | mitogen-activated protein kinase kinase 5 |
Aliases | MEK5; MAPKK5; HsT17454; PRKMK5; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPKK 5; ME ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MAP2K5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MAP2K5 |
Name | mitogen-activated protein kinase kinase 5 |
Aliases | MEK5; MAPKK5; HsT17454; PRKMK5; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPKK 5; ME ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MAP2K5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MAP2K5 |
Name | mitogen-activated protein kinase kinase 5 |
Aliases | MEK5; MAPKK5; HsT17454; PRKMK5; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPKK 5; ME ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MAP2K5 in various data sets.
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Points in the above scatter plot represent the mutation difference of MAP2K5 in various data sets.
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Summary | |
---|---|
Symbol | MAP2K5 |
Name | mitogen-activated protein kinase kinase 5 |
Aliases | MEK5; MAPKK5; HsT17454; PRKMK5; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPKK 5; ME ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MAP2K5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MAP2K5 |
Name | mitogen-activated protein kinase kinase 5 |
Aliases | MEK5; MAPKK5; HsT17454; PRKMK5; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPKK 5; ME ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MAP2K5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MAP2K5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MAP2K5 |
Name | mitogen-activated protein kinase kinase 5 |
Aliases | MEK5; MAPKK5; HsT17454; PRKMK5; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPKK 5; ME ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MAP2K5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MAP2K5 |
Name | mitogen-activated protein kinase kinase 5 |
Aliases | MEK5; MAPKK5; HsT17454; PRKMK5; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPKK 5; ME ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MAP2K5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MAP2K5 |
Name | mitogen-activated protein kinase kinase 5 |
Aliases | MEK5; MAPKK5; HsT17454; PRKMK5; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPKK 5; ME ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MAP2K5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MAP2K5 |
Name | mitogen-activated protein kinase kinase 5 |
Aliases | MEK5; MAPKK5; HsT17454; PRKMK5; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPKK 5; ME ...... |
Chromosomal Location | 15q22.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MAP2K5 collected from DrugBank database. |
There is no record. |