Summary | |
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Symbol | MAPK14 |
Name | mitogen-activated protein kinase 14 |
Aliases | PRKM14; Mxi2; PRKM15; p38 MAP kinase; CSPB1; CSBP1; CSBP2; EXIP; SAPK2A; p38ALPHA; CSAID-binding protein; Cs ...... |
Chromosomal Location | 6p21.3-p21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus |
Domain |
PF00069 Protein kinase domain |
Function |
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113'. ; FUNCTION: (Microbial infection) Activated by phosphorylation by M.tuberculosis EsxA in T-cells leading to inhibition of IFN-gamma production; phosphorylation is apparent within 15 minute and is inhibited by kinase-specific inhibitors SB203580 and siRNA (PubMed:21586573). |
Biological Process |
GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000187 activation of MAPK activity GO:0000768 syncytium formation by plasma membrane fusion GO:0001501 skeletal system development GO:0001502 cartilage condensation GO:0001503 ossification GO:0001525 angiogenesis GO:0001819 positive regulation of cytokine production GO:0001890 placenta development GO:0002062 chondrocyte differentiation GO:0002237 response to molecule of bacterial origin GO:0002262 myeloid cell homeostasis GO:0002521 leukocyte differentiation GO:0002532 production of molecular mediator involved in inflammatory response GO:0002534 cytokine production involved in inflammatory response GO:0002573 myeloid leukocyte differentiation GO:0005996 monosaccharide metabolic process GO:0006006 glucose metabolic process GO:0006606 protein import into nucleus GO:0006631 fatty acid metabolic process GO:0006913 nucleocytoplasmic transport GO:0006949 syncytium formation GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007265 Ras protein signal transduction GO:0007507 heart development GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0007520 myoblast fusion GO:0007568 aging GO:0007569 cell aging GO:0008643 carbohydrate transport GO:0008645 hexose transport GO:0009306 protein secretion GO:0009314 response to radiation GO:0009612 response to mechanical stimulus GO:0009615 response to virus GO:0010212 response to ionizing radiation GO:0010608 posttranscriptional regulation of gene expression GO:0010827 regulation of glucose transport GO:0010828 positive regulation of glucose transport GO:0010830 regulation of myotube differentiation GO:0010831 positive regulation of myotube differentiation GO:0014706 striated muscle tissue development GO:0014835 myoblast differentiation involved in skeletal muscle regeneration GO:0014855 striated muscle cell proliferation GO:0014902 myotube differentiation GO:0015749 monosaccharide transport GO:0015758 glucose transport GO:0016055 Wnt signaling pathway GO:0016202 regulation of striated muscle tissue development GO:0017038 protein import GO:0018105 peptidyl-serine phosphorylation GO:0018209 peptidyl-serine modification GO:0019318 hexose metabolic process GO:0019395 fatty acid oxidation GO:0030099 myeloid cell differentiation GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030218 erythrocyte differentiation GO:0030258 lipid modification GO:0030278 regulation of ossification GO:0030316 osteoclast differentiation GO:0031098 stress-activated protein kinase signaling cascade GO:0031099 regeneration GO:0031279 regulation of cyclase activity GO:0031281 positive regulation of cyclase activity GO:0031570 DNA integrity checkpoint GO:0031663 lipopolysaccharide-mediated signaling pathway GO:0032147 activation of protein kinase activity GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032495 response to muramyl dipeptide GO:0032496 response to lipopolysaccharide GO:0032615 interleukin-12 production GO:0032655 regulation of interleukin-12 production GO:0032735 positive regulation of interleukin-12 production GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0033002 muscle cell proliferation GO:0033157 regulation of intracellular protein transport GO:0033674 positive regulation of kinase activity GO:0034101 erythrocyte homeostasis GO:0034440 lipid oxidation GO:0034504 protein localization to nucleus GO:0035265 organ growth GO:0035924 cellular response to vascular endothelial growth factor stimulus GO:0035994 response to muscle stretch GO:0038066 p38MAPK cascade GO:0042246 tissue regeneration GO:0042306 regulation of protein import into nucleus GO:0042307 positive regulation of protein import into nucleus GO:0042692 muscle cell differentiation GO:0042770 signal transduction in response to DNA damage GO:0043403 skeletal muscle tissue regeneration GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043487 regulation of RNA stability GO:0043488 regulation of mRNA stability GO:0043489 RNA stabilization GO:0044723 single-organism carbohydrate metabolic process GO:0044744 protein targeting to nucleus GO:0045444 fat cell differentiation GO:0045445 myoblast differentiation GO:0045598 regulation of fat cell differentiation GO:0045600 positive regulation of fat cell differentiation GO:0045637 regulation of myeloid cell differentiation GO:0045639 positive regulation of myeloid cell differentiation GO:0045646 regulation of erythrocyte differentiation GO:0045648 positive regulation of erythrocyte differentiation GO:0045661 regulation of myoblast differentiation GO:0045663 positive regulation of myoblast differentiation GO:0045844 positive regulation of striated muscle tissue development GO:0045860 positive regulation of protein kinase activity GO:0045927 positive regulation of growth GO:0046323 glucose import GO:0046324 regulation of glucose import GO:0046326 positive regulation of glucose import GO:0046620 regulation of organ growth GO:0046622 positive regulation of organ growth GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0048010 vascular endothelial growth factor receptor signaling pathway GO:0048255 mRNA stabilization GO:0048514 blood vessel morphogenesis GO:0048608 reproductive structure development GO:0048634 regulation of muscle organ development GO:0048636 positive regulation of muscle organ development GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048705 skeletal system morphogenesis GO:0048738 cardiac muscle tissue development GO:0048872 homeostasis of number of cells GO:0050663 cytokine secretion GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0050727 regulation of inflammatory response GO:0050873 brown fat cell differentiation GO:0051047 positive regulation of secretion GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051149 positive regulation of muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0051155 positive regulation of striated muscle cell differentiation GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051216 cartilage development GO:0051222 positive regulation of protein transport GO:0051403 stress-activated MAPK cascade GO:0055017 cardiac muscle tissue growth GO:0055021 regulation of cardiac muscle tissue growth GO:0055023 positive regulation of cardiac muscle tissue growth GO:0055024 regulation of cardiac muscle tissue development GO:0055025 positive regulation of cardiac muscle tissue development GO:0060038 cardiac muscle cell proliferation GO:0060043 regulation of cardiac muscle cell proliferation GO:0060045 positive regulation of cardiac muscle cell proliferation GO:0060070 canonical Wnt signaling pathway GO:0060142 regulation of syncytium formation by plasma membrane fusion GO:0060143 positive regulation of syncytium formation by plasma membrane fusion GO:0060419 heart growth GO:0060420 regulation of heart growth GO:0060421 positive regulation of heart growth GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development GO:0060828 regulation of canonical Wnt signaling pathway GO:0061448 connective tissue development GO:0061458 reproductive system development GO:0070935 3'-UTR-mediated mRNA stabilization GO:0071214 cellular response to abiotic stimulus GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071396 cellular response to lipid GO:0071478 cellular response to radiation GO:0071479 cellular response to ionizing radiation GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072331 signal transduction by p53 class mediator GO:0072593 reactive oxygen species metabolic process GO:0072610 interleukin-12 secretion GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0090316 positive regulation of intracellular protein transport GO:0090335 regulation of brown fat cell differentiation GO:0090336 positive regulation of brown fat cell differentiation GO:0090398 cellular senescence GO:0090400 stress-induced premature senescence GO:0098586 cellular response to virus GO:0098743 cell aggregation GO:0198738 cell-cell signaling by wnt GO:1900015 regulation of cytokine production involved in inflammatory response GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1901652 response to peptide GO:1901739 regulation of myoblast fusion GO:1901741 positive regulation of myoblast fusion GO:1901796 regulation of signal transduction by p53 class mediator GO:1901861 regulation of muscle tissue development GO:1901863 positive regulation of muscle tissue development GO:1902593 single-organism nuclear import GO:1903532 positive regulation of secretion by cell GO:1903533 regulation of protein targeting GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1903829 positive regulation of cellular protein localization GO:1904589 regulation of protein import GO:1904591 positive regulation of protein import GO:1904951 positive regulation of establishment of protein localization GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2001182 regulation of interleukin-12 secretion GO:2001184 positive regulation of interleukin-12 secretion |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004702 receptor signaling protein serine/threonine kinase activity GO:0004707 MAP kinase activity GO:0004708 MAP kinase kinase activity GO:0004712 protein serine/threonine/tyrosine kinase activity GO:0005057 receptor signaling protein activity GO:0008134 transcription factor binding GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding GO:0051525 NFAT protein binding |
Cellular Component |
GO:0000922 spindle pole GO:0005819 spindle |
KEGG |
hsa04010 MAPK signaling pathway hsa04015 Rap1 signaling pathway hsa04068 FoxO signaling pathway hsa04071 Sphingolipid signaling pathway hsa04261 Adrenergic signaling in cardiomyocytes hsa04370 VEGF signaling pathway hsa04380 Osteoclast differentiation hsa04550 Signaling pathways regulating pluripotency of stem cells hsa04611 Platelet activation hsa04620 Toll-like receptor signaling pathway hsa04621 NOD-like receptor signaling pathway hsa04622 RIG-I-like receptor signaling pathway hsa04660 T cell receptor signaling pathway hsa04664 Fc epsilon RI signaling pathway hsa04668 TNF signaling pathway hsa04670 Leukocyte transendothelial migration hsa04722 Neurotrophin signaling pathway hsa04723 Retrograde endocannabinoid signaling hsa04728 Dopaminergic synapse hsa04750 Inflammatory mediator regulation of TRP channels hsa04912 GnRH signaling pathway hsa04914 Progesterone-mediated oocyte maturation hsa04917 Prolactin signaling pathway |
Reactome |
R-HSA-418592: ADP signalling through P2Y purinoceptor 1 R-HSA-166054: Activated TLR4 signalling R-HSA-2151209: Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-450341: Activation of the AP-1 family of transcription factors R-HSA-375170: CDO in myogenesis R-HSA-1500931: Cell-Cell communication R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-376172: DSCAM interactions R-HSA-1266738: Developmental Biology R-HSA-198753: ERK/MAPK targets R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-450604: KSRP (KHSRP) binds and destabilizes mRNA R-HSA-450294: MAP kinase activation in TLR cascade R-HSA-450282: MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-1592230: Mitochondrial biogenesis R-HSA-975871: MyD88 cascade initiated on plasma membrane R-HSA-975155: MyD88 dependent cascade initiated on endosome R-HSA-166166: MyD88-independent TLR3/TLR4 cascade R-HSA-166058: MyD88 R-HSA-525793: Myogenesis R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-168638: NOD1/2 Signaling Pathway R-HSA-6798695: Neutrophil degranulation R-HSA-198725: Nuclear Events (kinase and transcription factor activation) R-HSA-168643: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-418346: Platelet homeostasis R-HSA-432142: Platelet sensitization by LDL R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation R-HSA-450531: Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-162582: Signal Transduction R-HSA-392518: Signal amplification R-HSA-194138: Signaling by VEGF R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-168180: TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling R-HSA-168142: Toll Like Receptor 10 (TLR10) Cascade R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade R-HSA-168176: Toll Like Receptor 5 (TLR5) Cascade R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade R-HSA-168179: Toll Like Receptor TLR1 R-HSA-168188: Toll Like Receptor TLR6 R-HSA-168898: Toll-Like Receptors Cascades R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-450302: activated TAK1 mediates p38 MAPK activation R-HSA-171007: p38MAPK events |
Summary | |
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Symbol | MAPK14 |
Name | mitogen-activated protein kinase 14 |
Aliases | PRKM14; Mxi2; PRKM15; p38 MAP kinase; CSPB1; CSBP1; CSBP2; EXIP; SAPK2A; p38ALPHA; CSAID-binding protein; Cs ...... |
Chromosomal Location | 6p21.3-p21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MAPK14 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between MAPK14 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | MAPK14 |
Name | mitogen-activated protein kinase 14 |
Aliases | PRKM14; Mxi2; PRKM15; p38 MAP kinase; CSPB1; CSBP1; CSBP2; EXIP; SAPK2A; p38ALPHA; CSAID-binding protein; Cs ...... |
Chromosomal Location | 6p21.3-p21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MAPK14 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MAPK14 |
Name | mitogen-activated protein kinase 14 |
Aliases | PRKM14; Mxi2; PRKM15; p38 MAP kinase; CSPB1; CSBP1; CSBP2; EXIP; SAPK2A; p38ALPHA; CSAID-binding protein; Cs ...... |
Chromosomal Location | 6p21.3-p21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MAPK14 in various data sets.
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Points in the above scatter plot represent the mutation difference of MAPK14 in various data sets.
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Summary | |
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Symbol | MAPK14 |
Name | mitogen-activated protein kinase 14 |
Aliases | PRKM14; Mxi2; PRKM15; p38 MAP kinase; CSPB1; CSBP1; CSBP2; EXIP; SAPK2A; p38ALPHA; CSAID-binding protein; Cs ...... |
Chromosomal Location | 6p21.3-p21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MAPK14. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | MAPK14 |
Name | mitogen-activated protein kinase 14 |
Aliases | PRKM14; Mxi2; PRKM15; p38 MAP kinase; CSPB1; CSBP1; CSBP2; EXIP; SAPK2A; p38ALPHA; CSAID-binding protein; Cs ...... |
Chromosomal Location | 6p21.3-p21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MAPK14. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MAPK14. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MAPK14 |
Name | mitogen-activated protein kinase 14 |
Aliases | PRKM14; Mxi2; PRKM15; p38 MAP kinase; CSPB1; CSBP1; CSBP2; EXIP; SAPK2A; p38ALPHA; CSAID-binding protein; Cs ...... |
Chromosomal Location | 6p21.3-p21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MAPK14. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | MAPK14 |
Name | mitogen-activated protein kinase 14 |
Aliases | PRKM14; Mxi2; PRKM15; p38 MAP kinase; CSPB1; CSBP1; CSBP2; EXIP; SAPK2A; p38ALPHA; CSAID-binding protein; Cs ...... |
Chromosomal Location | 6p21.3-p21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MAPK14 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | MAPK14 |
Name | mitogen-activated protein kinase 14 |
Aliases | PRKM14; Mxi2; PRKM15; p38 MAP kinase; CSPB1; CSBP1; CSBP2; EXIP; SAPK2A; p38ALPHA; CSAID-binding protein; Cs ...... |
Chromosomal Location | 6p21.3-p21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MAPK14 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | MAPK14 |
Name | mitogen-activated protein kinase 14 |
Aliases | PRKM14; Mxi2; PRKM15; p38 MAP kinase; CSPB1; CSBP1; CSBP2; EXIP; SAPK2A; p38ALPHA; CSAID-binding protein; Cs ...... |
Chromosomal Location | 6p21.3-p21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MAPK14 collected from DrugBank database. |
Details on drugs targeting MAPK14.
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