Browse MAPK8IP2

Summary
SymbolMAPK8IP2
Namemitogen-activated protein kinase 8 interacting protein 2
Aliases IB2; JIP2; islet-brain 2; JNK-interacting protein 2; PRKM8IPL; PRKM8 interacting protein-like; IB-2; JNK MAP ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm. Note=Accumulates in cell surface projections.
Domain PF00640 Phosphotyrosine interaction domain (PTB/PID)
PF14604 Variant SH3 domain
Function

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).

> Gene Ontology
 
Biological Process GO:0001662 behavioral fear response
GO:0002209 behavioral defense response
GO:0007172 signal complex assembly
GO:0007215 glutamate receptor signaling pathway
GO:0007254 JNK cascade
GO:0007270 neuron-neuron synaptic transmission
GO:0007611 learning or memory
GO:0007612 learning
GO:0007617 mating behavior
GO:0007618 mating
GO:0010469 regulation of receptor activity
GO:0016358 dendrite development
GO:0019098 reproductive behavior
GO:0022898 regulation of transmembrane transporter activity
GO:0031098 stress-activated protein kinase signaling cascade
GO:0032409 regulation of transporter activity
GO:0032412 regulation of ion transmembrane transporter activity
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0033555 multicellular organismal response to stress
GO:0034762 regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035176 social behavior
GO:0035249 synaptic transmission, glutamatergic
GO:0042391 regulation of membrane potential
GO:0042596 fear response
GO:0043410 positive regulation of MAPK cascade
GO:0044708 single-organism behavior
GO:0046328 regulation of JNK cascade
GO:0046958 nonassociative learning
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048813 dendrite morphogenesis
GO:0050804 modulation of synaptic transmission
GO:0050890 cognition
GO:0051403 stress-activated MAPK cascade
GO:0051703 intraspecies interaction between organisms
GO:0051705 multi-organism behavior
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060078 regulation of postsynaptic membrane potential
GO:0060079 excitatory postsynaptic potential
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0099565 chemical synaptic transmission, postsynaptic
GO:0099601 regulation of neurotransmitter receptor activity
GO:1900449 regulation of glutamate receptor signaling pathway
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Molecular Function GO:0001540 beta-amyloid binding
GO:0005078 MAP-kinase scaffold activity
GO:0019894 kinesin binding
GO:0032947 protein complex scaffold
GO:0033218 amide binding
GO:0035591 signaling adaptor activity
GO:0042277 peptide binding
GO:0060090 binding, bridging
Cellular Component GO:0014069 postsynaptic density
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0060076 excitatory synapse
GO:0098794 postsynapse
GO:0099572 postsynaptic specialization
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
Reactome -
Summary
SymbolMAPK8IP2
Namemitogen-activated protein kinase 8 interacting protein 2
Aliases IB2; JIP2; islet-brain 2; JNK-interacting protein 2; PRKM8IPL; PRKM8 interacting protein-like; IB-2; JNK MAP ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MAPK8IP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolMAPK8IP2
Namemitogen-activated protein kinase 8 interacting protein 2
Aliases IB2; JIP2; islet-brain 2; JNK-interacting protein 2; PRKM8IPL; PRKM8 interacting protein-like; IB-2; JNK MAP ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MAPK8IP2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolMAPK8IP2
Namemitogen-activated protein kinase 8 interacting protein 2
Aliases IB2; JIP2; islet-brain 2; JNK-interacting protein 2; PRKM8IPL; PRKM8 interacting protein-like; IB-2; JNK MAP ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MAPK8IP2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.420.624
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6660.656
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2690.857
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1650.795
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2970.843
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0090.996
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.6180.399
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1310.91
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11121.4590.237
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.6920.428
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.8870.436
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.7940.00132
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of MAPK8IP2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolMAPK8IP2
Namemitogen-activated protein kinase 8 interacting protein 2
Aliases IB2; JIP2; islet-brain 2; JNK-interacting protein 2; PRKM8IPL; PRKM8 interacting protein-like; IB-2; JNK MAP ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MAPK8IP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMAPK8IP2
Namemitogen-activated protein kinase 8 interacting protein 2
Aliases IB2; JIP2; islet-brain 2; JNK-interacting protein 2; PRKM8IPL; PRKM8 interacting protein-like; IB-2; JNK MAP ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MAPK8IP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MAPK8IP2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMAPK8IP2
Namemitogen-activated protein kinase 8 interacting protein 2
Aliases IB2; JIP2; islet-brain 2; JNK-interacting protein 2; PRKM8IPL; PRKM8 interacting protein-like; IB-2; JNK MAP ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MAPK8IP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMAPK8IP2
Namemitogen-activated protein kinase 8 interacting protein 2
Aliases IB2; JIP2; islet-brain 2; JNK-interacting protein 2; PRKM8IPL; PRKM8 interacting protein-like; IB-2; JNK MAP ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MAPK8IP2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMAPK8IP2
Namemitogen-activated protein kinase 8 interacting protein 2
Aliases IB2; JIP2; islet-brain 2; JNK-interacting protein 2; PRKM8IPL; PRKM8 interacting protein-like; IB-2; JNK MAP ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MAPK8IP2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMAPK8IP2
Namemitogen-activated protein kinase 8 interacting protein 2
Aliases IB2; JIP2; islet-brain 2; JNK-interacting protein 2; PRKM8IPL; PRKM8 interacting protein-like; IB-2; JNK MAP ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MAPK8IP2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.