Browse MAPKAP1

Summary
SymbolMAPKAP1
Namemitogen-activated protein kinase associated protein 1
Aliases MGC2745; SIN1; stress-activated protein kinase-interacting 1; JC310; SIN1b; SIN1g; MEKK2-interacting protein ......
Chromosomal Location9q34.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.
Domain PF16978 SAPK-interacting protein 1 (Sin1)
PF05422 Stress-activated map kinase interacting protein 1 (SIN1)
PF16979 SAPK-interacting protein 1 (Sin1)
Function

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.

> Gene Ontology
 
Biological Process GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0007159 leukocyte cell-cell adhesion
GO:0007163 establishment or maintenance of cell polarity
GO:0007265 Ras protein signal transduction
GO:0021762 substantia nigra development
GO:0022407 regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0030901 midbrain development
GO:0030950 establishment or maintenance of actin cytoskeleton polarity
GO:0030952 establishment or maintenance of cytoskeleton polarity
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031294 lymphocyte costimulation
GO:0031295 T cell costimulation
GO:0031929 TOR signaling
GO:0038203 TORC2 signaling
GO:0042110 T cell activation
GO:0045785 positive regulation of cell adhesion
GO:0046578 regulation of Ras protein signal transduction
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048857 neural nucleus development
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050870 positive regulation of T cell activation
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051058 negative regulation of small GTPase mediated signal transduction
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0071593 lymphocyte aggregation
GO:1902532 negative regulation of intracellular signal transduction
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903039 positive regulation of leukocyte cell-cell adhesion
Molecular Function GO:0005543 phospholipid binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0017016 Ras GTPase binding
GO:0031267 small GTPase binding
GO:0035091 phosphatidylinositol binding
GO:0043168 anion binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0051020 GTPase binding
GO:0070300 phosphatidic acid binding
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
GO:1901981 phosphatidylinositol phosphate binding
GO:1902936 phosphatidylinositol bisphosphate binding
Cellular Component GO:0031932 TORC2 complex
GO:0038201 TOR complex
> KEGG and Reactome Pathway
 
KEGG hsa04150 mTOR signaling pathway
Reactome R-HSA-1280218: Adaptive Immune System
R-HSA-389356: CD28 co-stimulation
R-HSA-389357: CD28 dependent PI3K/Akt signaling
R-HSA-5674400: Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-388841: Costimulation by the CD28 family
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-186763: Downstream signal transduction
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-180292: GAB1 signalosome
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-2219528: PI3K/AKT Signaling in Cancer
R-HSA-198203: PI3K/AKT activation
R-HSA-1257604: PIP3 activates AKT signaling
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804757: Regulation of TP53 Degradation
R-HSA-6806003: Regulation of TP53 Expression and Degradation
R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-186797: Signaling by PDGF
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-194138: Signaling by VEGF
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-3700989: Transcriptional Regulation by TP53
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218920: VEGFR2 mediated vascular permeability
Summary
SymbolMAPKAP1
Namemitogen-activated protein kinase associated protein 1
Aliases MGC2745; SIN1; stress-activated protein kinase-interacting 1; JC310; SIN1b; SIN1g; MEKK2-interacting protein ......
Chromosomal Location9q34.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MAPKAP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolMAPKAP1
Namemitogen-activated protein kinase associated protein 1
Aliases MGC2745; SIN1; stress-activated protein kinase-interacting 1; JC310; SIN1b; SIN1g; MEKK2-interacting protein ......
Chromosomal Location9q34.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MAPKAP1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen Total # shRNA with >= 4-fold: 1 Resistant to T-cell proliferation
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolMAPKAP1
Namemitogen-activated protein kinase associated protein 1
Aliases MGC2745; SIN1; stress-activated protein kinase-interacting 1; JC310; SIN1b; SIN1g; MEKK2-interacting protein ......
Chromosomal Location9q34.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MAPKAP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0470.807
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.280.902
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2890.866
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.030.926
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2660.888
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4110.874
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1020.791
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1510.931
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0350.986
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2480.883
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6630.79
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.050.343
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of MAPKAP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382707.4-7.40.169
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1614014.3-14.30.209
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolMAPKAP1
Namemitogen-activated protein kinase associated protein 1
Aliases MGC2745; SIN1; stress-activated protein kinase-interacting 1; JC310; SIN1b; SIN1g; MEKK2-interacting protein ......
Chromosomal Location9q34.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MAPKAP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMAPKAP1
Namemitogen-activated protein kinase associated protein 1
Aliases MGC2745; SIN1; stress-activated protein kinase-interacting 1; JC310; SIN1b; SIN1g; MEKK2-interacting protein ......
Chromosomal Location9q34.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MAPKAP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MAPKAP1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMAPKAP1
Namemitogen-activated protein kinase associated protein 1
Aliases MGC2745; SIN1; stress-activated protein kinase-interacting 1; JC310; SIN1b; SIN1g; MEKK2-interacting protein ......
Chromosomal Location9q34.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MAPKAP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMAPKAP1
Namemitogen-activated protein kinase associated protein 1
Aliases MGC2745; SIN1; stress-activated protein kinase-interacting 1; JC310; SIN1b; SIN1g; MEKK2-interacting protein ......
Chromosomal Location9q34.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MAPKAP1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMAPKAP1
Namemitogen-activated protein kinase associated protein 1
Aliases MGC2745; SIN1; stress-activated protein kinase-interacting 1; JC310; SIN1b; SIN1g; MEKK2-interacting protein ......
Chromosomal Location9q34.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MAPKAP1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMAPKAP1
Namemitogen-activated protein kinase associated protein 1
Aliases MGC2745; SIN1; stress-activated protein kinase-interacting 1; JC310; SIN1b; SIN1g; MEKK2-interacting protein ......
Chromosomal Location9q34.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MAPKAP1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.