Summary | |
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Symbol | MARCH5 |
Name | membrane-associated ring finger (C3HC4) 5 |
Aliases | FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ...... |
Chromosomal Location | 10q23.32-q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion outer membrane Multi-pass membrane protein Endoplasmic reticulum membrane Multi-pass membrane protein Note=Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266). Authors (PubMed:16874301) show its presence only in mitochondria (PubMed:16874301). |
Domain |
PF12906 RING-variant domain |
Function |
Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1. |
Biological Process |
GO:0000209 protein polyubiquitination GO:0000266 mitochondrial fission GO:0007568 aging GO:0007569 cell aging GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0051865 protein autoubiquitination GO:0070585 protein localization to mitochondrion GO:0090140 regulation of mitochondrial fission GO:0090141 positive regulation of mitochondrial fission GO:0090342 regulation of cell aging GO:0090344 negative regulation of cell aging |
Molecular Function |
GO:0004842 ubiquitin-protein transferase activity GO:0016874 ligase activity GO:0019787 ubiquitin-like protein transferase activity GO:0051020 GTPase binding |
Cellular Component |
GO:0005741 mitochondrial outer membrane GO:0019867 outer membrane GO:0031968 organelle outer membrane |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | MARCH5 |
Name | membrane-associated ring finger (C3HC4) 5 |
Aliases | FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ...... |
Chromosomal Location | 10q23.32-q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MARCH5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MARCH5 |
Name | membrane-associated ring finger (C3HC4) 5 |
Aliases | FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ...... |
Chromosomal Location | 10q23.32-q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MARCH5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MARCH5 |
Name | membrane-associated ring finger (C3HC4) 5 |
Aliases | FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ...... |
Chromosomal Location | 10q23.32-q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MARCH5 in various data sets.
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Points in the above scatter plot represent the mutation difference of MARCH5 in various data sets.
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Summary | |
---|---|
Symbol | MARCH5 |
Name | membrane-associated ring finger (C3HC4) 5 |
Aliases | FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ...... |
Chromosomal Location | 10q23.32-q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MARCH5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | MARCH5 |
Name | membrane-associated ring finger (C3HC4) 5 |
Aliases | FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ...... |
Chromosomal Location | 10q23.32-q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MARCH5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MARCH5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MARCH5 |
Name | membrane-associated ring finger (C3HC4) 5 |
Aliases | FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ...... |
Chromosomal Location | 10q23.32-q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MARCH5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | MARCH5 |
Name | membrane-associated ring finger (C3HC4) 5 |
Aliases | FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ...... |
Chromosomal Location | 10q23.32-q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MARCH5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | MARCH5 |
Name | membrane-associated ring finger (C3HC4) 5 |
Aliases | FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ...... |
Chromosomal Location | 10q23.32-q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MARCH5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MARCH5 |
Name | membrane-associated ring finger (C3HC4) 5 |
Aliases | FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ...... |
Chromosomal Location | 10q23.32-q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MARCH5 collected from DrugBank database. |
There is no record. |