Browse MARCH5

Summary
SymbolMARCH5
Namemembrane-associated ring finger (C3HC4) 5
Aliases FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ......
Chromosomal Location10q23.32-q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion outer membrane Multi-pass membrane protein Endoplasmic reticulum membrane Multi-pass membrane protein Note=Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266). Authors (PubMed:16874301) show its presence only in mitochondria (PubMed:16874301).
Domain PF12906 RING-variant domain
Function

Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.

> Gene Ontology
 
Biological Process GO:0000209 protein polyubiquitination
GO:0000266 mitochondrial fission
GO:0007568 aging
GO:0007569 cell aging
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0051865 protein autoubiquitination
GO:0070585 protein localization to mitochondrion
GO:0090140 regulation of mitochondrial fission
GO:0090141 positive regulation of mitochondrial fission
GO:0090342 regulation of cell aging
GO:0090344 negative regulation of cell aging
Molecular Function GO:0004842 ubiquitin-protein transferase activity
GO:0016874 ligase activity
GO:0019787 ubiquitin-like protein transferase activity
GO:0051020 GTPase binding
Cellular Component GO:0005741 mitochondrial outer membrane
GO:0019867 outer membrane
GO:0031968 organelle outer membrane
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolMARCH5
Namemembrane-associated ring finger (C3HC4) 5
Aliases FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ......
Chromosomal Location10q23.32-q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MARCH5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolMARCH5
Namemembrane-associated ring finger (C3HC4) 5
Aliases FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ......
Chromosomal Location10q23.32-q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MARCH5 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.55; FDR: 0.00700 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolMARCH5
Namemembrane-associated ring finger (C3HC4) 5
Aliases FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ......
Chromosomal Location10q23.32-q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MARCH5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1810.398
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1780.908
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1880.86
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91601
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 5901
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 4701
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0120.973
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0360.981
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0660.968
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.3170.774
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.460.765
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1220.031
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of MARCH5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolMARCH5
Namemembrane-associated ring finger (C3HC4) 5
Aliases FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ......
Chromosomal Location10q23.32-q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MARCH5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMARCH5
Namemembrane-associated ring finger (C3HC4) 5
Aliases FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ......
Chromosomal Location10q23.32-q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MARCH5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MARCH5.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMARCH5
Namemembrane-associated ring finger (C3HC4) 5
Aliases FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ......
Chromosomal Location10q23.32-q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MARCH5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMARCH5
Namemembrane-associated ring finger (C3HC4) 5
Aliases FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ......
Chromosomal Location10q23.32-q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MARCH5 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMARCH5
Namemembrane-associated ring finger (C3HC4) 5
Aliases FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ......
Chromosomal Location10q23.32-q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MARCH5 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMARCH5
Namemembrane-associated ring finger (C3HC4) 5
Aliases FLJ20445; MARCH-V; RNF153; ring finger protein 153; MITOL; membrane-associated RING finger protein 5; membra ......
Chromosomal Location10q23.32-q23.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MARCH5 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.