Summary | |
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Symbol | MARCO |
Name | macrophage receptor with collagenous structure |
Aliases | SCARA2; scavenger receptor class A, member 2; Scavenger receptor class A member 2; Macrophage receptor MARCO |
Chromosomal Location | 2q14.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type II membrane protein |
Domain |
PF01391 Collagen triple helix repeat (20 copies) PF00530 Scavenger receptor cysteine-rich domain |
Function |
Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (PubMed:12847263). |
Biological Process |
GO:0002218 activation of innate immune response GO:0002221 pattern recognition receptor signaling pathway GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0006898 receptor-mediated endocytosis GO:0006909 phagocytosis GO:0031349 positive regulation of defense response GO:0043277 apoptotic cell clearance GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response |
Molecular Function |
GO:0005044 scavenger receptor activity GO:0008329 signaling pattern recognition receptor activity GO:0038024 cargo receptor activity GO:0038187 pattern recognition receptor activity |
Cellular Component |
GO:0005581 collagen trimer GO:0030139 endocytic vesicle GO:0030659 cytoplasmic vesicle membrane GO:0030666 endocytic vesicle membrane |
KEGG |
hsa04145 Phagosome |
Reactome |
R-HSA-2173782: Binding and Uptake of Ligands by Scavenger Receptors R-HSA-3000480: Scavenging by Class A Receptors R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | MARCO |
Name | macrophage receptor with collagenous structure |
Aliases | SCARA2; scavenger receptor class A, member 2; Scavenger receptor class A member 2; Macrophage receptor MARCO |
Chromosomal Location | 2q14.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MARCO and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between MARCO and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | MARCO |
Name | macrophage receptor with collagenous structure |
Aliases | SCARA2; scavenger receptor class A, member 2; Scavenger receptor class A member 2; Macrophage receptor MARCO |
Chromosomal Location | 2q14.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MARCO in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MARCO |
Name | macrophage receptor with collagenous structure |
Aliases | SCARA2; scavenger receptor class A, member 2; Scavenger receptor class A member 2; Macrophage receptor MARCO |
Chromosomal Location | 2q14.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MARCO in various data sets.
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Points in the above scatter plot represent the mutation difference of MARCO in various data sets.
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Summary | |
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Symbol | MARCO |
Name | macrophage receptor with collagenous structure |
Aliases | SCARA2; scavenger receptor class A, member 2; Scavenger receptor class A member 2; Macrophage receptor MARCO |
Chromosomal Location | 2q14.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MARCO. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | MARCO |
Name | macrophage receptor with collagenous structure |
Aliases | SCARA2; scavenger receptor class A, member 2; Scavenger receptor class A member 2; Macrophage receptor MARCO |
Chromosomal Location | 2q14.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MARCO. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MARCO. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MARCO |
Name | macrophage receptor with collagenous structure |
Aliases | SCARA2; scavenger receptor class A, member 2; Scavenger receptor class A member 2; Macrophage receptor MARCO |
Chromosomal Location | 2q14.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MARCO. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | MARCO |
Name | macrophage receptor with collagenous structure |
Aliases | SCARA2; scavenger receptor class A, member 2; Scavenger receptor class A member 2; Macrophage receptor MARCO |
Chromosomal Location | 2q14.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MARCO expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | MARCO |
Name | macrophage receptor with collagenous structure |
Aliases | SCARA2; scavenger receptor class A, member 2; Scavenger receptor class A member 2; Macrophage receptor MARCO |
Chromosomal Location | 2q14.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MARCO and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | MARCO |
Name | macrophage receptor with collagenous structure |
Aliases | SCARA2; scavenger receptor class A, member 2; Scavenger receptor class A member 2; Macrophage receptor MARCO |
Chromosomal Location | 2q14.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MARCO collected from DrugBank database. |
Details on drugs targeting MARCO.
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