Summary | |
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Symbol | MAT2B |
Name | methionine adenosyltransferase II, beta |
Aliases | MATIIbeta; SDR23E1; short chain dehydrogenase/reductase family 23E, member 1; Nbla02999; MAT II beta; beta r ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF04321 RmlD substrate binding domain |
Function |
Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511). |
Biological Process |
GO:0006556 S-adenosylmethionine biosynthetic process GO:0006730 one-carbon metabolic process GO:0006732 coenzyme metabolic process GO:0006790 sulfur compound metabolic process GO:0009108 coenzyme biosynthetic process GO:0032259 methylation GO:0044272 sulfur compound biosynthetic process GO:0046500 S-adenosylmethionine metabolic process GO:0051186 cofactor metabolic process GO:0051188 cofactor biosynthetic process |
Molecular Function |
GO:0048270 methionine adenosyltransferase regulator activity |
Cellular Component |
GO:0048269 methionine adenosyltransferase complex |
KEGG |
hsa00270 Cysteine and methionine metabolism hsa01100 Metabolic pathways hsa01230 Biosynthesis of amino acids |
Reactome |
R-HSA-211859: Biological oxidations R-HSA-5688426: Deubiquitination R-HSA-1430728: Metabolism R-HSA-392499: Metabolism of proteins R-HSA-156581: Methylation R-HSA-156580: Phase II conjugation R-HSA-597592: Post-translational protein modification R-HSA-5689880: Ub-specific processing proteases |
Summary | |
---|---|
Symbol | MAT2B |
Name | methionine adenosyltransferase II, beta |
Aliases | MATIIbeta; SDR23E1; short chain dehydrogenase/reductase family 23E, member 1; Nbla02999; MAT II beta; beta r ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MAT2B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MAT2B |
Name | methionine adenosyltransferase II, beta |
Aliases | MATIIbeta; SDR23E1; short chain dehydrogenase/reductase family 23E, member 1; Nbla02999; MAT II beta; beta r ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MAT2B in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | MAT2B |
Name | methionine adenosyltransferase II, beta |
Aliases | MATIIbeta; SDR23E1; short chain dehydrogenase/reductase family 23E, member 1; Nbla02999; MAT II beta; beta r ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MAT2B in various data sets.
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Points in the above scatter plot represent the mutation difference of MAT2B in various data sets.
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Summary | |
---|---|
Symbol | MAT2B |
Name | methionine adenosyltransferase II, beta |
Aliases | MATIIbeta; SDR23E1; short chain dehydrogenase/reductase family 23E, member 1; Nbla02999; MAT II beta; beta r ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MAT2B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MAT2B |
Name | methionine adenosyltransferase II, beta |
Aliases | MATIIbeta; SDR23E1; short chain dehydrogenase/reductase family 23E, member 1; Nbla02999; MAT II beta; beta r ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MAT2B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MAT2B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MAT2B |
Name | methionine adenosyltransferase II, beta |
Aliases | MATIIbeta; SDR23E1; short chain dehydrogenase/reductase family 23E, member 1; Nbla02999; MAT II beta; beta r ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MAT2B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MAT2B |
Name | methionine adenosyltransferase II, beta |
Aliases | MATIIbeta; SDR23E1; short chain dehydrogenase/reductase family 23E, member 1; Nbla02999; MAT II beta; beta r ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MAT2B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MAT2B |
Name | methionine adenosyltransferase II, beta |
Aliases | MATIIbeta; SDR23E1; short chain dehydrogenase/reductase family 23E, member 1; Nbla02999; MAT II beta; beta r ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MAT2B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MAT2B |
Name | methionine adenosyltransferase II, beta |
Aliases | MATIIbeta; SDR23E1; short chain dehydrogenase/reductase family 23E, member 1; Nbla02999; MAT II beta; beta r ...... |
Chromosomal Location | 5q34 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MAT2B collected from DrugBank database. |
There is no record. |