Summary | |
---|---|
Symbol | MAU2 |
Name | MAU2 sister chromatid cohesion factor |
Aliases | MGC75361; mau-2; MAU2L; SCC4; sister chromatid cohesion 4; KIAA0892; MAU2 chromatid cohesion factor homolog ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus, nucleoplasm Nucleus Chromosome Note=Binds to chromatin from the end of mitosis until prophase. |
Domain |
PF10345 Cohesin loading factor |
Function |
Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin (PubMed:28167679, PubMed:22628566). Plays a role in sister chromatid cohesion and normal progression through prometaphase (PubMed:16802858, PubMed:16682347). |
Biological Process |
GO:0000070 mitotic sister chromatid segregation GO:0000819 sister chromatid segregation GO:0007059 chromosome segregation GO:0007062 sister chromatid cohesion GO:0007064 mitotic sister chromatid cohesion GO:0007067 mitotic nuclear division GO:0034086 maintenance of sister chromatid cohesion GO:0034088 maintenance of mitotic sister chromatid cohesion GO:0098813 nuclear chromosome segregation |
Molecular Function |
GO:0047485 protein N-terminus binding |
Cellular Component |
GO:0000785 chromatin GO:0032116 SMC loading complex |
KEGG | - |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-2470946: Cohesin Loading onto Chromatin R-HSA-68886: M Phase R-HSA-68884: Mitotic Telophase/Cytokinesis |
Summary | |
---|---|
Symbol | MAU2 |
Name | MAU2 sister chromatid cohesion factor |
Aliases | MGC75361; mau-2; MAU2L; SCC4; sister chromatid cohesion 4; KIAA0892; MAU2 chromatid cohesion factor homolog ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MAU2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MAU2 |
Name | MAU2 sister chromatid cohesion factor |
Aliases | MGC75361; mau-2; MAU2L; SCC4; sister chromatid cohesion 4; KIAA0892; MAU2 chromatid cohesion factor homolog ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of MAU2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | MAU2 |
Name | MAU2 sister chromatid cohesion factor |
Aliases | MGC75361; mau-2; MAU2L; SCC4; sister chromatid cohesion 4; KIAA0892; MAU2 chromatid cohesion factor homolog ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MAU2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of MAU2 in various data sets.
|
Summary | |
---|---|
Symbol | MAU2 |
Name | MAU2 sister chromatid cohesion factor |
Aliases | MGC75361; mau-2; MAU2L; SCC4; sister chromatid cohesion 4; KIAA0892; MAU2 chromatid cohesion factor homolog ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MAU2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MAU2 |
Name | MAU2 sister chromatid cohesion factor |
Aliases | MGC75361; mau-2; MAU2L; SCC4; sister chromatid cohesion 4; KIAA0892; MAU2 chromatid cohesion factor homolog ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MAU2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MAU2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MAU2 |
Name | MAU2 sister chromatid cohesion factor |
Aliases | MGC75361; mau-2; MAU2L; SCC4; sister chromatid cohesion 4; KIAA0892; MAU2 chromatid cohesion factor homolog ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MAU2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MAU2 |
Name | MAU2 sister chromatid cohesion factor |
Aliases | MGC75361; mau-2; MAU2L; SCC4; sister chromatid cohesion 4; KIAA0892; MAU2 chromatid cohesion factor homolog ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MAU2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MAU2 |
Name | MAU2 sister chromatid cohesion factor |
Aliases | MGC75361; mau-2; MAU2L; SCC4; sister chromatid cohesion 4; KIAA0892; MAU2 chromatid cohesion factor homolog ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MAU2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MAU2 |
Name | MAU2 sister chromatid cohesion factor |
Aliases | MGC75361; mau-2; MAU2L; SCC4; sister chromatid cohesion 4; KIAA0892; MAU2 chromatid cohesion factor homolog ...... |
Chromosomal Location | 19p13.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MAU2 collected from DrugBank database. |
There is no record. |