Summary | |
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Symbol | MBNL2 |
Name | muscleblind-like splicing regulator 2 |
Aliases | MBLL; MBLL39; muscleblind-like 2 (Drosophila); PRO2032; muscleblind-like 2; muscleblind-like protein-like 39 ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm Note=Greater concentration in the nucleus. Expressed in or near large cytoplasmic adhesion plaques (PubMed:16273094). Location in the cytoplasm is microtubule-dependent (PubMed:16273094). In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts (PubMed:11929853). |
Domain |
PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) |
Function |
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM). |
Biological Process |
GO:0000375 RNA splicing, via transesterification reactions GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile GO:0000380 alternative mRNA splicing, via spliceosome GO:0000381 regulation of alternative mRNA splicing, via spliceosome GO:0000398 mRNA splicing, via spliceosome GO:0006397 mRNA processing GO:0008380 RNA splicing GO:0043484 regulation of RNA splicing GO:0048024 regulation of mRNA splicing, via spliceosome GO:0050684 regulation of mRNA processing GO:1903311 regulation of mRNA metabolic process |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | MBNL2 |
Name | muscleblind-like splicing regulator 2 |
Aliases | MBLL; MBLL39; muscleblind-like 2 (Drosophila); PRO2032; muscleblind-like 2; muscleblind-like protein-like 39 ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MBNL2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MBNL2 |
Name | muscleblind-like splicing regulator 2 |
Aliases | MBLL; MBLL39; muscleblind-like 2 (Drosophila); PRO2032; muscleblind-like 2; muscleblind-like protein-like 39 ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MBNL2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MBNL2 |
Name | muscleblind-like splicing regulator 2 |
Aliases | MBLL; MBLL39; muscleblind-like 2 (Drosophila); PRO2032; muscleblind-like 2; muscleblind-like protein-like 39 ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MBNL2 in various data sets.
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Points in the above scatter plot represent the mutation difference of MBNL2 in various data sets.
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Summary | |
---|---|
Symbol | MBNL2 |
Name | muscleblind-like splicing regulator 2 |
Aliases | MBLL; MBLL39; muscleblind-like 2 (Drosophila); PRO2032; muscleblind-like 2; muscleblind-like protein-like 39 ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MBNL2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MBNL2 |
Name | muscleblind-like splicing regulator 2 |
Aliases | MBLL; MBLL39; muscleblind-like 2 (Drosophila); PRO2032; muscleblind-like 2; muscleblind-like protein-like 39 ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MBNL2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MBNL2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MBNL2 |
Name | muscleblind-like splicing regulator 2 |
Aliases | MBLL; MBLL39; muscleblind-like 2 (Drosophila); PRO2032; muscleblind-like 2; muscleblind-like protein-like 39 ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MBNL2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MBNL2 |
Name | muscleblind-like splicing regulator 2 |
Aliases | MBLL; MBLL39; muscleblind-like 2 (Drosophila); PRO2032; muscleblind-like 2; muscleblind-like protein-like 39 ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MBNL2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MBNL2 |
Name | muscleblind-like splicing regulator 2 |
Aliases | MBLL; MBLL39; muscleblind-like 2 (Drosophila); PRO2032; muscleblind-like 2; muscleblind-like protein-like 39 ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MBNL2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MBNL2 |
Name | muscleblind-like splicing regulator 2 |
Aliases | MBLL; MBLL39; muscleblind-like 2 (Drosophila); PRO2032; muscleblind-like 2; muscleblind-like protein-like 39 ...... |
Chromosomal Location | 13q31.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MBNL2 collected from DrugBank database. |
There is no record. |