Browse MBTPS2

Summary
SymbolMBTPS2
Namemembrane-bound transcription factor peptidase, site 2
Aliases S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ......
Chromosomal LocationXp22.12-p22.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Multi-pass membrane protein Cytoplasm
Domain PF02163 Peptidase family M50
Function

Intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.

> Gene Ontology
 
Biological Process GO:0006066 alcohol metabolic process
GO:0006984 ER-nucleus signaling pathway
GO:0006986 response to unfolded protein
GO:0008202 steroid metabolic process
GO:0008203 cholesterol metabolic process
GO:0016125 sterol metabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031293 membrane protein intracellular domain proteolysis
GO:0033619 membrane protein proteolysis
GO:0034620 cellular response to unfolded protein
GO:0034976 response to endoplasmic reticulum stress
GO:0035966 response to topologically incorrect protein
GO:0035967 cellular response to topologically incorrect protein
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0036500 ATF6-mediated unfolded protein response
GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress
GO:0043620 regulation of DNA-templated transcription in response to stress
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:1901615 organic hydroxy compound metabolic process
GO:1902652 secondary alcohol metabolic process
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
Molecular Function GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04141 Protein processing in endoplasmic reticulum
Reactome R-HSA-381033: ATF6 (ATF6-alpha) activates chaperones
R-HSA-174800: Chylomicron-mediated lipid transport
R-HSA-73923: Lipid digestion, mobilization, and transport
R-HSA-174824: Lipoprotein metabolism
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-392499: Metabolism of proteins
R-HSA-1655829: Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-381119: Unfolded Protein Response (UPR)
Summary
SymbolMBTPS2
Namemembrane-bound transcription factor peptidase, site 2
Aliases S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ......
Chromosomal LocationXp22.12-p22.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MBTPS2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolMBTPS2
Namemembrane-bound transcription factor peptidase, site 2
Aliases S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ......
Chromosomal LocationXp22.12-p22.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MBTPS2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.72 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolMBTPS2
Namemembrane-bound transcription factor peptidase, site 2
Aliases S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ......
Chromosomal LocationXp22.12-p22.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MBTPS2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2660.369
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.5960.71
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0230.985
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1630.546
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1480.942
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.5560.828
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0650.87
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3340.837
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2360.896
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4910.635
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6880.67
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0560.367
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of MBTPS2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.407.40.0709
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.407.40.096
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolMBTPS2
Namemembrane-bound transcription factor peptidase, site 2
Aliases S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ......
Chromosomal LocationXp22.12-p22.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MBTPS2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMBTPS2
Namemembrane-bound transcription factor peptidase, site 2
Aliases S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ......
Chromosomal LocationXp22.12-p22.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MBTPS2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MBTPS2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMBTPS2
Namemembrane-bound transcription factor peptidase, site 2
Aliases S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ......
Chromosomal LocationXp22.12-p22.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MBTPS2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMBTPS2
Namemembrane-bound transcription factor peptidase, site 2
Aliases S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ......
Chromosomal LocationXp22.12-p22.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MBTPS2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMBTPS2
Namemembrane-bound transcription factor peptidase, site 2
Aliases S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ......
Chromosomal LocationXp22.12-p22.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MBTPS2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMBTPS2
Namemembrane-bound transcription factor peptidase, site 2
Aliases S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ......
Chromosomal LocationXp22.12-p22.11
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MBTPS2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.