Summary | |
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Symbol | MBTPS2 |
Name | membrane-bound transcription factor peptidase, site 2 |
Aliases | S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ...... |
Chromosomal Location | Xp22.12-p22.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Multi-pass membrane protein Cytoplasm |
Domain |
PF02163 Peptidase family M50 |
Function |
Intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop. |
Biological Process |
GO:0006066 alcohol metabolic process GO:0006984 ER-nucleus signaling pathway GO:0006986 response to unfolded protein GO:0008202 steroid metabolic process GO:0008203 cholesterol metabolic process GO:0016125 sterol metabolic process GO:0030968 endoplasmic reticulum unfolded protein response GO:0031293 membrane protein intracellular domain proteolysis GO:0033619 membrane protein proteolysis GO:0034620 cellular response to unfolded protein GO:0034976 response to endoplasmic reticulum stress GO:0035966 response to topologically incorrect protein GO:0035967 cellular response to topologically incorrect protein GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036500 ATF6-mediated unfolded protein response GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress GO:0043620 regulation of DNA-templated transcription in response to stress GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:1901615 organic hydroxy compound metabolic process GO:1902652 secondary alcohol metabolic process GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004222 metalloendopeptidase activity GO:0008237 metallopeptidase activity |
Cellular Component | - |
KEGG |
hsa04141 Protein processing in endoplasmic reticulum |
Reactome |
R-HSA-381033: ATF6 (ATF6-alpha) activates chaperones R-HSA-174800: Chylomicron-mediated lipid transport R-HSA-73923: Lipid digestion, mobilization, and transport R-HSA-174824: Lipoprotein metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-392499: Metabolism of proteins R-HSA-1655829: Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-381119: Unfolded Protein Response (UPR) |
Summary | |
---|---|
Symbol | MBTPS2 |
Name | membrane-bound transcription factor peptidase, site 2 |
Aliases | S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ...... |
Chromosomal Location | Xp22.12-p22.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MBTPS2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MBTPS2 |
Name | membrane-bound transcription factor peptidase, site 2 |
Aliases | S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ...... |
Chromosomal Location | Xp22.12-p22.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MBTPS2 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | MBTPS2 |
Name | membrane-bound transcription factor peptidase, site 2 |
Aliases | S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ...... |
Chromosomal Location | Xp22.12-p22.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MBTPS2 in various data sets.
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Points in the above scatter plot represent the mutation difference of MBTPS2 in various data sets.
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Summary | |
---|---|
Symbol | MBTPS2 |
Name | membrane-bound transcription factor peptidase, site 2 |
Aliases | S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ...... |
Chromosomal Location | Xp22.12-p22.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MBTPS2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MBTPS2 |
Name | membrane-bound transcription factor peptidase, site 2 |
Aliases | S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ...... |
Chromosomal Location | Xp22.12-p22.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MBTPS2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MBTPS2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MBTPS2 |
Name | membrane-bound transcription factor peptidase, site 2 |
Aliases | S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ...... |
Chromosomal Location | Xp22.12-p22.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MBTPS2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MBTPS2 |
Name | membrane-bound transcription factor peptidase, site 2 |
Aliases | S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ...... |
Chromosomal Location | Xp22.12-p22.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MBTPS2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MBTPS2 |
Name | membrane-bound transcription factor peptidase, site 2 |
Aliases | S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ...... |
Chromosomal Location | Xp22.12-p22.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MBTPS2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MBTPS2 |
Name | membrane-bound transcription factor peptidase, site 2 |
Aliases | S2P; membrane-bound transcription factor protease, site 2; keratosis follicularis spinulosa decalvans; BRESE ...... |
Chromosomal Location | Xp22.12-p22.11 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MBTPS2 collected from DrugBank database. |
There is no record. |