Summary | |
---|---|
Symbol | MCL1 |
Name | myeloid cell leukemia 1 |
Aliases | BCL2L3; Mcl-1; myeloid cell leukemia sequence 1 (BCL2-related); EAT-ES; MCL1L; MCL1S; bcl2-L-3; mcl1/EAT; bc ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass membrane protein Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria. |
Domain |
PF00452 Apoptosis regulator proteins |
Function |
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. |
Biological Process |
GO:0001709 cell fate determination GO:0006914 autophagy GO:0006979 response to oxidative stress GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008637 apoptotic mitochondrial changes GO:0010506 regulation of autophagy GO:0010507 negative regulation of autophagy GO:0034599 cellular response to oxidative stress GO:0036473 cell death in response to oxidative stress GO:0036475 neuron death in response to oxidative stress GO:0036480 neuron intrinsic apoptotic signaling pathway in response to oxidative stress GO:0038034 signal transduction in absence of ligand GO:0043276 anoikis GO:0043523 regulation of neuron apoptotic process GO:0043525 positive regulation of neuron apoptotic process GO:0045165 cell fate commitment GO:0051402 neuron apoptotic process GO:0070997 neuron death GO:0071806 protein transmembrane transport GO:0097191 extrinsic apoptotic signaling pathway GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:0097193 intrinsic apoptotic signaling pathway GO:1900407 regulation of cellular response to oxidative stress GO:1900409 positive regulation of cellular response to oxidative stress GO:1901099 negative regulation of signal transduction in absence of ligand GO:1901214 regulation of neuron death GO:1901216 positive regulation of neuron death GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902532 negative regulation of intracellular signal transduction GO:1902882 regulation of response to oxidative stress GO:1902884 positive regulation of response to oxidative stress GO:1903201 regulation of oxidative stress-induced cell death GO:1903203 regulation of oxidative stress-induced neuron death GO:1903209 positive regulation of oxidative stress-induced cell death GO:1903223 positive regulation of oxidative stress-induced neuron death GO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:2000209 regulation of anoikis GO:2000811 negative regulation of anoikis GO:2001020 regulation of response to DNA damage stimulus GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway GO:2001244 positive regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0008320 protein transmembrane transporter activity GO:0008565 protein transporter activity GO:0015266 protein channel activity GO:0015267 channel activity GO:0022803 passive transmembrane transporter activity GO:0022884 macromolecule transmembrane transporter activity GO:0046982 protein heterodimerization activity GO:0051400 BH domain binding GO:0051434 BH3 domain binding GO:0070513 death domain binding |
Cellular Component |
GO:0005741 mitochondrial outer membrane GO:0005759 mitochondrial matrix GO:0019867 outer membrane GO:0031968 organelle outer membrane GO:0097136 Bcl-2 family protein complex |
KEGG |
hsa04151 PI3K-Akt signaling pathway hsa04210 Apoptosis hsa04630 Jak-STAT signaling pathway |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-449147: Signaling by Interleukins |
Summary | |
---|---|
Symbol | MCL1 |
Name | myeloid cell leukemia 1 |
Aliases | BCL2L3; Mcl-1; myeloid cell leukemia sequence 1 (BCL2-related); EAT-ES; MCL1L; MCL1S; bcl2-L-3; mcl1/EAT; bc ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MCL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between MCL1 and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | MCL1 |
Name | myeloid cell leukemia 1 |
Aliases | BCL2L3; Mcl-1; myeloid cell leukemia sequence 1 (BCL2-related); EAT-ES; MCL1L; MCL1S; bcl2-L-3; mcl1/EAT; bc ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of MCL1 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | MCL1 |
Name | myeloid cell leukemia 1 |
Aliases | BCL2L3; Mcl-1; myeloid cell leukemia sequence 1 (BCL2-related); EAT-ES; MCL1L; MCL1S; bcl2-L-3; mcl1/EAT; bc ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MCL1 in various data sets.
|
Points in the above scatter plot represent the mutation difference of MCL1 in various data sets.
|
Summary | |
---|---|
Symbol | MCL1 |
Name | myeloid cell leukemia 1 |
Aliases | BCL2L3; Mcl-1; myeloid cell leukemia sequence 1 (BCL2-related); EAT-ES; MCL1L; MCL1S; bcl2-L-3; mcl1/EAT; bc ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MCL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MCL1 |
Name | myeloid cell leukemia 1 |
Aliases | BCL2L3; Mcl-1; myeloid cell leukemia sequence 1 (BCL2-related); EAT-ES; MCL1L; MCL1S; bcl2-L-3; mcl1/EAT; bc ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MCL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MCL1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | MCL1 |
Name | myeloid cell leukemia 1 |
Aliases | BCL2L3; Mcl-1; myeloid cell leukemia sequence 1 (BCL2-related); EAT-ES; MCL1L; MCL1S; bcl2-L-3; mcl1/EAT; bc ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MCL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MCL1 |
Name | myeloid cell leukemia 1 |
Aliases | BCL2L3; Mcl-1; myeloid cell leukemia sequence 1 (BCL2-related); EAT-ES; MCL1L; MCL1S; bcl2-L-3; mcl1/EAT; bc ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MCL1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MCL1 |
Name | myeloid cell leukemia 1 |
Aliases | BCL2L3; Mcl-1; myeloid cell leukemia sequence 1 (BCL2-related); EAT-ES; MCL1L; MCL1S; bcl2-L-3; mcl1/EAT; bc ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MCL1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MCL1 |
Name | myeloid cell leukemia 1 |
Aliases | BCL2L3; Mcl-1; myeloid cell leukemia sequence 1 (BCL2-related); EAT-ES; MCL1L; MCL1S; bcl2-L-3; mcl1/EAT; bc ...... |
Chromosomal Location | 1q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MCL1 collected from DrugBank database. |
Details on drugs targeting MCL1.
|