Summary | |
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Symbol | MDH1B |
Name | malate dehydrogenase 1B, NAD (soluble) |
Aliases | FLJ25341; RP11-95H11; Putative malate dehydrogenase 1B |
Chromosomal Location | 2q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain | - |
Function |
- |
Biological Process |
GO:0006091 generation of precursor metabolites and energy GO:0006099 tricarboxylic acid cycle GO:0006107 oxaloacetate metabolic process GO:0006108 malate metabolic process GO:0006732 coenzyme metabolic process GO:0006733 oxidoreduction coenzyme metabolic process GO:0006734 NADH metabolic process GO:0009060 aerobic respiration GO:0015980 energy derivation by oxidation of organic compounds GO:0019362 pyridine nucleotide metabolic process GO:0019674 NAD metabolic process GO:0043648 dicarboxylic acid metabolic process GO:0045333 cellular respiration GO:0046496 nicotinamide nucleotide metabolic process GO:0051186 cofactor metabolic process GO:0072524 pyridine-containing compound metabolic process |
Molecular Function |
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GO:0016615 malate dehydrogenase activity GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0030060 L-malate dehydrogenase activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | MDH1B |
Name | malate dehydrogenase 1B, NAD (soluble) |
Aliases | FLJ25341; RP11-95H11; Putative malate dehydrogenase 1B |
Chromosomal Location | 2q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MDH1B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MDH1B |
Name | malate dehydrogenase 1B, NAD (soluble) |
Aliases | FLJ25341; RP11-95H11; Putative malate dehydrogenase 1B |
Chromosomal Location | 2q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MDH1B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MDH1B |
Name | malate dehydrogenase 1B, NAD (soluble) |
Aliases | FLJ25341; RP11-95H11; Putative malate dehydrogenase 1B |
Chromosomal Location | 2q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MDH1B in various data sets.
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Points in the above scatter plot represent the mutation difference of MDH1B in various data sets.
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Summary | |
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Symbol | MDH1B |
Name | malate dehydrogenase 1B, NAD (soluble) |
Aliases | FLJ25341; RP11-95H11; Putative malate dehydrogenase 1B |
Chromosomal Location | 2q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MDH1B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | MDH1B |
Name | malate dehydrogenase 1B, NAD (soluble) |
Aliases | FLJ25341; RP11-95H11; Putative malate dehydrogenase 1B |
Chromosomal Location | 2q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MDH1B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MDH1B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MDH1B |
Name | malate dehydrogenase 1B, NAD (soluble) |
Aliases | FLJ25341; RP11-95H11; Putative malate dehydrogenase 1B |
Chromosomal Location | 2q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MDH1B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | MDH1B |
Name | malate dehydrogenase 1B, NAD (soluble) |
Aliases | FLJ25341; RP11-95H11; Putative malate dehydrogenase 1B |
Chromosomal Location | 2q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MDH1B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | MDH1B |
Name | malate dehydrogenase 1B, NAD (soluble) |
Aliases | FLJ25341; RP11-95H11; Putative malate dehydrogenase 1B |
Chromosomal Location | 2q33.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MDH1B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |