Summary | |
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Symbol | MDM2 |
Name | MDM2 proto-oncogene, E3 ubiquitin protein ligase |
Aliases | HDM2; MGC5370; mouse double minute 2, human homolog of; p53-binding protein; Mdm2, transformed 3T3 cell doub ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Note=Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus. |
Domain |
PF02201 SWIB/MDM2 domain PF00641 Zn-finger in Ran binding protein and others |
Function |
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). |
Biological Process |
GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000082 G1/S transition of mitotic cell cycle GO:0000302 response to reactive oxygen species GO:0001666 response to hypoxia GO:0001974 blood vessel remodeling GO:0002027 regulation of heart rate GO:0003007 heart morphogenesis GO:0003013 circulatory system process GO:0003015 heart process GO:0003170 heart valve development GO:0003171 atrioventricular valve development GO:0003179 heart valve morphogenesis GO:0003181 atrioventricular valve morphogenesis GO:0003197 endocardial cushion development GO:0003203 endocardial cushion morphogenesis GO:0003205 cardiac chamber development GO:0003206 cardiac chamber morphogenesis GO:0003230 cardiac atrium development GO:0003231 cardiac ventricle development GO:0003279 cardiac septum development GO:0003281 ventricular septum development GO:0003283 atrial septum development GO:0006611 protein export from nucleus GO:0006913 nucleocytoplasmic transport GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006979 response to oxidative stress GO:0007050 cell cycle arrest GO:0007089 traversing start control point of mitotic cell cycle GO:0007093 mitotic cell cycle checkpoint GO:0007346 regulation of mitotic cell cycle GO:0007507 heart development GO:0007584 response to nutrient GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0009314 response to radiation GO:0009411 response to UV GO:0009416 response to light stimulus GO:0009636 response to toxic substance GO:0009743 response to carbohydrate GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0009991 response to extracellular stimulus GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010039 response to iron ion GO:0010225 response to UV-C GO:0010266 response to vitamin B1 GO:0010466 negative regulation of peptidase activity GO:0010498 proteasomal protein catabolic process GO:0010721 negative regulation of cell development GO:0010948 negative regulation of cell cycle process GO:0010951 negative regulation of endopeptidase activity GO:0010955 negative regulation of protein processing GO:0010975 regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0014072 response to isoquinoline alkaloid GO:0014812 muscle cell migration GO:0014909 smooth muscle cell migration GO:0014910 regulation of smooth muscle cell migration GO:0014911 positive regulation of smooth muscle cell migration GO:0016485 protein processing GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0030335 positive regulation of cell migration GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031345 negative regulation of cell projection organization GO:0031570 DNA integrity checkpoint GO:0031571 mitotic G1 DNA damage checkpoint GO:0031647 regulation of protein stability GO:0031648 protein destabilization GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0031670 cellular response to nutrient GO:0032026 response to magnesium ion GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0033002 muscle cell proliferation GO:0033157 regulation of intracellular protein transport GO:0033273 response to vitamin GO:0034504 protein localization to nucleus GO:0034599 cellular response to oxidative stress GO:0034614 cellular response to reactive oxygen species GO:0034644 cellular response to UV GO:0035902 response to immobilization stress GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0040017 positive regulation of locomotion GO:0042176 regulation of protein catabolic process GO:0042220 response to cocaine GO:0042493 response to drug GO:0042542 response to hydrogen peroxide GO:0042770 signal transduction in response to DNA damage GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043278 response to morphine GO:0043279 response to alkaloid GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043434 response to peptide hormone GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043627 response to estrogen GO:0044057 regulation of system process GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044773 mitotic DNA damage checkpoint GO:0044774 mitotic DNA integrity checkpoint GO:0044783 G1 DNA damage checkpoint GO:0044819 mitotic G1/S transition checkpoint GO:0044843 cell cycle G1/S phase transition GO:0045472 response to ether GO:0045665 negative regulation of neuron differentiation GO:0045732 positive regulation of protein catabolic process GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045861 negative regulation of proteolysis GO:0045862 positive regulation of proteolysis GO:0045930 negative regulation of mitotic cell cycle GO:0045931 positive regulation of mitotic cell cycle GO:0046677 response to antibiotic GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0046825 regulation of protein export from nucleus GO:0046827 positive regulation of protein export from nucleus GO:0048545 response to steroid hormone GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0048771 tissue remodeling GO:0050768 negative regulation of neurogenesis GO:0051168 nuclear export GO:0051169 nuclear transport GO:0051222 positive regulation of protein transport GO:0051272 positive regulation of cellular component movement GO:0051346 negative regulation of hydrolase activity GO:0051604 protein maturation GO:0051961 negative regulation of nervous system development GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0060047 heart contraction GO:0060411 cardiac septum morphogenesis GO:0060485 mesenchyme development GO:0061136 regulation of proteasomal protein catabolic process GO:0070301 cellular response to hydrogen peroxide GO:0070482 response to oxygen levels GO:0070613 regulation of protein processing GO:0071156 regulation of cell cycle arrest GO:0071157 negative regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0071214 cellular response to abiotic stimulus GO:0071236 cellular response to antibiotic GO:0071295 cellular response to vitamin GO:0071301 cellular response to vitamin B1 GO:0071312 cellular response to alkaloid GO:0071375 cellular response to peptide hormone stimulus GO:0071391 cellular response to estrogen stimulus GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0071478 cellular response to radiation GO:0071482 cellular response to light stimulus GO:0071494 cellular response to UV-C GO:0071496 cellular response to external stimulus GO:0072132 mesenchyme morphogenesis GO:0072331 signal transduction by p53 class mediator GO:0072395 signal transduction involved in cell cycle checkpoint GO:0072401 signal transduction involved in DNA integrity checkpoint GO:0072413 signal transduction involved in mitotic cell cycle checkpoint GO:0072422 signal transduction involved in DNA damage checkpoint GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint GO:0090068 positive regulation of cell cycle process GO:0090316 positive regulation of intracellular protein transport GO:1900087 positive regulation of G1/S transition of mitotic cell cycle GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1901796 regulation of signal transduction by p53 class mediator GO:1901797 negative regulation of signal transduction by p53 class mediator GO:1901800 positive regulation of proteasomal protein catabolic process GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1901989 positive regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901991 negative regulation of mitotic cell cycle phase transition GO:1901992 positive regulation of mitotic cell cycle phase transition GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint GO:1902402 signal transduction involved in mitotic DNA damage checkpoint GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint GO:1902532 negative regulation of intracellular signal transduction GO:1902806 regulation of cell cycle G1/S phase transition GO:1902807 negative regulation of cell cycle G1/S phase transition GO:1902808 positive regulation of cell cycle G1/S phase transition GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process GO:1903317 regulation of protein maturation GO:1903318 negative regulation of protein maturation GO:1903362 regulation of cellular protein catabolic process GO:1903364 positive regulation of cellular protein catabolic process GO:1903522 regulation of blood circulation GO:1903829 positive regulation of cellular protein localization GO:1904705 regulation of vascular smooth muscle cell proliferation GO:1904707 positive regulation of vascular smooth muscle cell proliferation GO:1904738 vascular associated smooth muscle cell migration GO:1904752 regulation of vascular associated smooth muscle cell migration GO:1904754 positive regulation of vascular associated smooth muscle cell migration GO:1904951 positive regulation of establishment of protein localization GO:1990267 response to transition metal nanoparticle GO:1990785 response to water-immersion restraint stress GO:1990874 vascular smooth muscle cell proliferation GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000117 negative regulation of cysteine-type endopeptidase activity GO:2000134 negative regulation of G1/S transition of mitotic cell cycle GO:2000147 positive regulation of cell motility GO:2001020 regulation of response to DNA damage stimulus GO:2001021 negative regulation of response to DNA damage stimulus |
Molecular Function |
GO:0002039 p53 binding GO:0004842 ubiquitin-protein transferase activity GO:0016874 ligase activity GO:0019787 ubiquitin-like protein transferase activity GO:0019789 SUMO transferase activity GO:0031625 ubiquitin protein ligase binding GO:0042975 peroxisome proliferator activated receptor binding GO:0044389 ubiquitin-like protein ligase binding GO:0061630 ubiquitin protein ligase activity GO:0061659 ubiquitin-like protein ligase activity GO:0097110 scaffold protein binding |
Cellular Component |
GO:0016604 nuclear body GO:0030139 endocytic vesicle GO:0030659 cytoplasmic vesicle membrane GO:0030666 endocytic vesicle membrane |
KEGG |
hsa04068 FoxO signaling pathway hsa04110 Cell cycle hsa04115 p53 signaling pathway hsa04120 Ubiquitin mediated proteolysis hsa04144 Endocytosis hsa04151 PI3K-Akt signaling pathway hsa04919 Thyroid hormone signaling pathway |
Reactome |
R-HSA-198323: AKT phosphorylates targets in the cytosol R-HSA-1280218: Adaptive Immune System R-HSA-1640170: Cell Cycle R-HSA-69620: Cell Cycle Checkpoints R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-5674400: Constitutive Signaling by AKT1 E17K in Cancer R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-5688426: Deubiquitination R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-69615: G1/S DNA Damage Checkpoints R-HSA-180292: GAB1 signalosome R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-399721: Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-392499: Metabolism of proteins R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-112316: Neuronal System R-HSA-112314: Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-2559585: Oncogene Induced Senescence R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-2219528: PI3K/AKT Signaling in Cancer R-HSA-198203: PI3K/AKT activation R-HSA-1257604: PIP3 activates AKT signaling R-HSA-597592: Post-translational protein modification R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804760: Regulation of TP53 Activity through Methylation R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation R-HSA-6804757: Regulation of TP53 Degradation R-HSA-6806003: Regulation of TP53 Expression and Degradation R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-3232118: SUMOylation of transcription factors R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-69541: Stabilization of p53 R-HSA-399719: Trafficking of AMPA receptors R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-112315: Transmission across Chemical Synapses R-HSA-5689880: Ub-specific processing proteases R-HSA-69563: p53-Dependent G1 DNA Damage Response R-HSA-69580: p53-Dependent G1/S DNA damage checkpoint |
Summary | |
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Symbol | MDM2 |
Name | MDM2 proto-oncogene, E3 ubiquitin protein ligase |
Aliases | HDM2; MGC5370; mouse double minute 2, human homolog of; p53-binding protein; Mdm2, transformed 3T3 cell doub ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MDM2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between MDM2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | MDM2 |
Name | MDM2 proto-oncogene, E3 ubiquitin protein ligase |
Aliases | HDM2; MGC5370; mouse double minute 2, human homolog of; p53-binding protein; Mdm2, transformed 3T3 cell doub ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MDM2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MDM2 |
Name | MDM2 proto-oncogene, E3 ubiquitin protein ligase |
Aliases | HDM2; MGC5370; mouse double minute 2, human homolog of; p53-binding protein; Mdm2, transformed 3T3 cell doub ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MDM2 in various data sets.
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Points in the above scatter plot represent the mutation difference of MDM2 in various data sets.
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Summary | |
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Symbol | MDM2 |
Name | MDM2 proto-oncogene, E3 ubiquitin protein ligase |
Aliases | HDM2; MGC5370; mouse double minute 2, human homolog of; p53-binding protein; Mdm2, transformed 3T3 cell doub ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MDM2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | MDM2 |
Name | MDM2 proto-oncogene, E3 ubiquitin protein ligase |
Aliases | HDM2; MGC5370; mouse double minute 2, human homolog of; p53-binding protein; Mdm2, transformed 3T3 cell doub ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MDM2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MDM2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MDM2 |
Name | MDM2 proto-oncogene, E3 ubiquitin protein ligase |
Aliases | HDM2; MGC5370; mouse double minute 2, human homolog of; p53-binding protein; Mdm2, transformed 3T3 cell doub ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MDM2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | MDM2 |
Name | MDM2 proto-oncogene, E3 ubiquitin protein ligase |
Aliases | HDM2; MGC5370; mouse double minute 2, human homolog of; p53-binding protein; Mdm2, transformed 3T3 cell doub ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MDM2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | MDM2 |
Name | MDM2 proto-oncogene, E3 ubiquitin protein ligase |
Aliases | HDM2; MGC5370; mouse double minute 2, human homolog of; p53-binding protein; Mdm2, transformed 3T3 cell doub ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MDM2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | MDM2 |
Name | MDM2 proto-oncogene, E3 ubiquitin protein ligase |
Aliases | HDM2; MGC5370; mouse double minute 2, human homolog of; p53-binding protein; Mdm2, transformed 3T3 cell doub ...... |
Chromosomal Location | 12q13-q14 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MDM2 collected from DrugBank database. |
Details on drugs targeting MDM2.
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