Summary | |
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Symbol | MED12 |
Name | mediator complex subunit 12 |
Aliases | CAGH45; HOPA; TRAP230; KIAA0192; OKS; TNRC11; FGS1; trinucleotide repeat containing 11 (THR-associated prote ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF09497 Transcription mediator complex subunit Med12 PF12145 Eukaryotic Mediator 12 subunit domain PF12144 Eukaryotic Mediator 12 catenin-binding domain |
Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
Biological Process |
GO:0001501 skeletal system development GO:0001736 establishment of planar polarity GO:0001738 morphogenesis of a polarized epithelium GO:0001756 somitogenesis GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0001843 neural tube closure GO:0003002 regionalization GO:0003401 axis elongation GO:0006352 DNA-templated transcription, initiation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0007164 establishment of tissue polarity GO:0007389 pattern specification process GO:0007422 peripheral nervous system development GO:0007492 endoderm development GO:0007507 heart development GO:0009755 hormone-mediated signaling pathway GO:0009952 anterior/posterior pattern specification GO:0010001 glial cell differentiation GO:0014003 oligodendrocyte development GO:0014020 primary neural tube formation GO:0014037 Schwann cell differentiation GO:0014044 Schwann cell development GO:0016055 Wnt signaling pathway GO:0016331 morphogenesis of embryonic epithelium GO:0019827 stem cell population maintenance GO:0021510 spinal cord development GO:0021782 glial cell development GO:0021915 neural tube development GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030521 androgen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0035282 segmentation GO:0035567 non-canonical Wnt signaling pathway GO:0036342 post-anal tail morphogenesis GO:0042063 gliogenesis GO:0043401 steroid hormone mediated signaling pathway GO:0048545 response to steroid hormone GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048701 embryonic cranial skeleton morphogenesis GO:0048702 embryonic neurocranium morphogenesis GO:0048704 embryonic skeletal system morphogenesis GO:0048705 skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:0048709 oligodendrocyte differentiation GO:0060070 canonical Wnt signaling pathway GO:0060071 Wnt signaling pathway, planar cell polarity pathway GO:0060560 developmental growth involved in morphogenesis GO:0060562 epithelial tube morphogenesis GO:0060606 tube closure GO:0061053 somite development GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0072175 epithelial tube formation GO:0090175 regulation of establishment of planar polarity GO:0090245 axis elongation involved in somitogenesis GO:0098727 maintenance of cell number GO:0198738 cell-cell signaling by wnt GO:1904888 cranial skeletal system development GO:1905330 regulation of morphogenesis of an epithelium GO:1990403 embryonic brain development GO:2000027 regulation of organ morphogenesis |
Molecular Function |
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0001105 RNA polymerase II transcription coactivator activity GO:0001158 enhancer sequence-specific DNA binding GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0004842 ubiquitin-protein transferase activity GO:0008013 beta-catenin binding GO:0008022 protein C-terminus binding GO:0008134 transcription factor binding GO:0019787 ubiquitin-like protein transferase activity GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity GO:0035257 nuclear hormone receptor binding GO:0035326 enhancer binding GO:0042809 vitamin D receptor binding GO:0046966 thyroid hormone receptor binding GO:0051427 hormone receptor binding GO:0061630 ubiquitin protein ligase activity GO:0061659 ubiquitin-like protein ligase activity GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding |
Cellular Component |
GO:0000151 ubiquitin ligase complex GO:0005813 centrosome GO:0016592 mediator complex |
KEGG |
hsa04919 Thyroid hormone signaling pathway |
Reactome |
R-HSA-1266738: Developmental Biology R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1989781: PPARA activates gene expression R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-381340: Transcriptional regulation of white adipocyte differentiation |
Summary | |
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Symbol | MED12 |
Name | mediator complex subunit 12 |
Aliases | CAGH45; HOPA; TRAP230; KIAA0192; OKS; TNRC11; FGS1; trinucleotide repeat containing 11 (THR-associated prote ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MED12 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MED12 |
Name | mediator complex subunit 12 |
Aliases | CAGH45; HOPA; TRAP230; KIAA0192; OKS; TNRC11; FGS1; trinucleotide repeat containing 11 (THR-associated prote ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MED12 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MED12 |
Name | mediator complex subunit 12 |
Aliases | CAGH45; HOPA; TRAP230; KIAA0192; OKS; TNRC11; FGS1; trinucleotide repeat containing 11 (THR-associated prote ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MED12 in various data sets.
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Points in the above scatter plot represent the mutation difference of MED12 in various data sets.
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Summary | |
---|---|
Symbol | MED12 |
Name | mediator complex subunit 12 |
Aliases | CAGH45; HOPA; TRAP230; KIAA0192; OKS; TNRC11; FGS1; trinucleotide repeat containing 11 (THR-associated prote ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MED12. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MED12 |
Name | mediator complex subunit 12 |
Aliases | CAGH45; HOPA; TRAP230; KIAA0192; OKS; TNRC11; FGS1; trinucleotide repeat containing 11 (THR-associated prote ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MED12. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MED12. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MED12 |
Name | mediator complex subunit 12 |
Aliases | CAGH45; HOPA; TRAP230; KIAA0192; OKS; TNRC11; FGS1; trinucleotide repeat containing 11 (THR-associated prote ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MED12. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MED12 |
Name | mediator complex subunit 12 |
Aliases | CAGH45; HOPA; TRAP230; KIAA0192; OKS; TNRC11; FGS1; trinucleotide repeat containing 11 (THR-associated prote ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MED12 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MED12 |
Name | mediator complex subunit 12 |
Aliases | CAGH45; HOPA; TRAP230; KIAA0192; OKS; TNRC11; FGS1; trinucleotide repeat containing 11 (THR-associated prote ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MED12 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MED12 |
Name | mediator complex subunit 12 |
Aliases | CAGH45; HOPA; TRAP230; KIAA0192; OKS; TNRC11; FGS1; trinucleotide repeat containing 11 (THR-associated prote ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MED12 collected from DrugBank database. |
There is no record. |