Summary | |
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Symbol | MED16 |
Name | mediator complex subunit 16 |
Aliases | DRIP92; TRAP95; THRAP5; thyroid hormone receptor associated protein 5; thyroid hormone receptor-associated p ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF11635 Mediator complex subunit 16 |
Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
Biological Process |
GO:0006352 DNA-templated transcription, initiation GO:0006367 transcription initiation from RNA polymerase II promoter GO:0009755 hormone-mediated signaling pathway GO:0010469 regulation of receptor activity GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030521 androgen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0043401 steroid hormone mediated signaling pathway GO:0048545 response to steroid hormone GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:2000273 positive regulation of receptor activity |
Molecular Function |
GO:0003713 transcription coactivator activity GO:0008134 transcription factor binding GO:0010861 thyroid hormone receptor activator activity GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity GO:0030375 thyroid hormone receptor coactivator activity GO:0030545 receptor regulator activity GO:0030546 receptor activator activity GO:0035257 nuclear hormone receptor binding GO:0042809 vitamin D receptor binding GO:0046966 thyroid hormone receptor binding GO:0051427 hormone receptor binding |
Cellular Component |
GO:0016592 mediator complex |
KEGG |
hsa04919 Thyroid hormone signaling pathway |
Reactome |
R-HSA-1266738: Developmental Biology R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1989781: PPARA activates gene expression R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-381340: Transcriptional regulation of white adipocyte differentiation |
Summary | |
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Symbol | MED16 |
Name | mediator complex subunit 16 |
Aliases | DRIP92; TRAP95; THRAP5; thyroid hormone receptor associated protein 5; thyroid hormone receptor-associated p ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between MED16 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | MED16 |
Name | mediator complex subunit 16 |
Aliases | DRIP92; TRAP95; THRAP5; thyroid hormone receptor associated protein 5; thyroid hormone receptor-associated p ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of MED16 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | MED16 |
Name | mediator complex subunit 16 |
Aliases | DRIP92; TRAP95; THRAP5; thyroid hormone receptor associated protein 5; thyroid hormone receptor-associated p ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of MED16 in various data sets.
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Points in the above scatter plot represent the mutation difference of MED16 in various data sets.
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Summary | |
---|---|
Symbol | MED16 |
Name | mediator complex subunit 16 |
Aliases | DRIP92; TRAP95; THRAP5; thyroid hormone receptor associated protein 5; thyroid hormone receptor-associated p ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MED16. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | MED16 |
Name | mediator complex subunit 16 |
Aliases | DRIP92; TRAP95; THRAP5; thyroid hormone receptor associated protein 5; thyroid hormone receptor-associated p ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MED16. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MED16. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | MED16 |
Name | mediator complex subunit 16 |
Aliases | DRIP92; TRAP95; THRAP5; thyroid hormone receptor associated protein 5; thyroid hormone receptor-associated p ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MED16. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | MED16 |
Name | mediator complex subunit 16 |
Aliases | DRIP92; TRAP95; THRAP5; thyroid hormone receptor associated protein 5; thyroid hormone receptor-associated p ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of MED16 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | MED16 |
Name | mediator complex subunit 16 |
Aliases | DRIP92; TRAP95; THRAP5; thyroid hormone receptor associated protein 5; thyroid hormone receptor-associated p ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between MED16 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | MED16 |
Name | mediator complex subunit 16 |
Aliases | DRIP92; TRAP95; THRAP5; thyroid hormone receptor associated protein 5; thyroid hormone receptor-associated p ...... |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting MED16 collected from DrugBank database. |
There is no record. |